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Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study.

Chew, Michelle LU ; Linder, Adam LU ; Santén, Stefan LU ; Ersson, Anders LU ; Herwald, Heiko LU and Thorlacius, Henrik LU (2012) In Inflammation Research 61(4). p.375-379
Abstract
OBJECTIVE: Heparin-binding protein (HBP) is a potent inducer of increased vascular permeability. The purpose of this study was to examine plasma levels of HBP in patients with shock. DESIGN: Fifty-three consecutive patients with septic and non-septic shock at a mixed-bed intensive care unit were included, as well as 20 age-matched controls. Patients with local infections but without signs of shock served as infectious controls. Enzyme-linked immunosorbent assay was used to determine plasma levels of HBP. RESULTS: There were no differences in serum HBP levels between healthy controls and those with local infections, including urinary tract infections, pneumonia and gastroenteritis, without shock. Levels of HBP were higher in patients with... (More)
OBJECTIVE: Heparin-binding protein (HBP) is a potent inducer of increased vascular permeability. The purpose of this study was to examine plasma levels of HBP in patients with shock. DESIGN: Fifty-three consecutive patients with septic and non-septic shock at a mixed-bed intensive care unit were included, as well as 20 age-matched controls. Patients with local infections but without signs of shock served as infectious controls. Enzyme-linked immunosorbent assay was used to determine plasma levels of HBP. RESULTS: There were no differences in serum HBP levels between healthy controls and those with local infections, including urinary tract infections, pneumonia and gastroenteritis, without shock. Levels of HBP were higher in patients with non-septic shock and septic shock than healthy controls. However, there was no difference in serum HBP levels between patients with septic shock and those with non-septic shock. Moreover, HBP levels were not different between patients with low and high APACHE II scores. Plasma levels of HBP were similar in surviving and non-surviving patients with shock. CONCLUSIONS: HBP is elevated in patients with shock from septic and non-septic etiologies. Future investigations are required to define the functional role of HBP in patients with shock. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Inflammation Research
volume
61
issue
4
pages
375 - 379
publisher
Birkhaüser
external identifiers
  • wos:000301778300012
  • pmid:22207392
  • scopus:84863107168
ISSN
1420-908X
DOI
10.1007/s00011-011-0422-6
language
English
LU publication?
yes
id
95ceb12a-c75a-4750-b72e-c08aa468e52e (old id 2273435)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22207392?dopt=Abstract
date added to LUP
2012-01-03 16:22:43
date last changed
2017-07-23 04:50:57
@article{95ceb12a-c75a-4750-b72e-c08aa468e52e,
  abstract     = {OBJECTIVE: Heparin-binding protein (HBP) is a potent inducer of increased vascular permeability. The purpose of this study was to examine plasma levels of HBP in patients with shock. DESIGN: Fifty-three consecutive patients with septic and non-septic shock at a mixed-bed intensive care unit were included, as well as 20 age-matched controls. Patients with local infections but without signs of shock served as infectious controls. Enzyme-linked immunosorbent assay was used to determine plasma levels of HBP. RESULTS: There were no differences in serum HBP levels between healthy controls and those with local infections, including urinary tract infections, pneumonia and gastroenteritis, without shock. Levels of HBP were higher in patients with non-septic shock and septic shock than healthy controls. However, there was no difference in serum HBP levels between patients with septic shock and those with non-septic shock. Moreover, HBP levels were not different between patients with low and high APACHE II scores. Plasma levels of HBP were similar in surviving and non-surviving patients with shock. CONCLUSIONS: HBP is elevated in patients with shock from septic and non-septic etiologies. Future investigations are required to define the functional role of HBP in patients with shock.},
  author       = {Chew, Michelle and Linder, Adam and Santén, Stefan and Ersson, Anders and Herwald, Heiko and Thorlacius, Henrik},
  issn         = {1420-908X},
  language     = {eng},
  number       = {4},
  pages        = {375--379},
  publisher    = {Birkhaüser},
  series       = {Inflammation Research},
  title        = {Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study.},
  url          = {http://dx.doi.org/10.1007/s00011-011-0422-6},
  volume       = {61},
  year         = {2012},
}