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Increased levels of hemoglobin and alpha1-microglobulin in Huntington's disease.

Gram, Magnus LU ; Davidsson, Sara; Muhammad, Zara Din; Lahiri, Nayana; Tabrizi, Sarah J; Åkerström, Bo LU and Björkqvist, Maria LU (2012) In Frontiers in Bioscience (Elite Edition) 4. p.950-957
Abstract
Hemoglobin released from damaged erythrocytes is a major pro-oxidant, generator of free radicals and inflammatory mediator. Huntington's disease is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities, in which oxidative stress has been suggested as a possible pathogenic mechanism. In the present work we have investigated levels of hemoglobin and markers of oxidative damage, including the heme- and radical-scavenger alpha1-microglobulin, in plasma and urine samples from two separate sample cohorts, including controls, premanifest gene carriers and subjects at different stages of Huntington's disease. The results show statistically significant increased levels of hemoglobin and... (More)
Hemoglobin released from damaged erythrocytes is a major pro-oxidant, generator of free radicals and inflammatory mediator. Huntington's disease is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities, in which oxidative stress has been suggested as a possible pathogenic mechanism. In the present work we have investigated levels of hemoglobin and markers of oxidative damage, including the heme- and radical-scavenger alpha1-microglobulin, in plasma and urine samples from two separate sample cohorts, including controls, premanifest gene carriers and subjects at different stages of Huntington's disease. The results show statistically significant increased levels of hemoglobin and alpha1-microglobulin in Huntington's disease urine samples. Interestingly, urine hemoglobin levels correlate with clinical severity. The results suggest that hemolysis may be linked to the pathogenesis of Huntington's disease and that assay of hemoglobin and alpha1-microglobulin may provide biomarkers that are linked to biologically relevant processes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Bioscience (Elite Edition)
volume
4
pages
950 - 957
publisher
Frontiers
external identifiers
  • pmid:22201927
ISSN
1945-0508
language
English
LU publication?
yes
id
591797fa-09ec-4d83-b4e8-becc0d1a384b (old id 2273508)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22201927?dopt=Abstract
date added to LUP
2012-01-03 21:36:16
date last changed
2016-04-16 05:54:21
@article{591797fa-09ec-4d83-b4e8-becc0d1a384b,
  abstract     = {Hemoglobin released from damaged erythrocytes is a major pro-oxidant, generator of free radicals and inflammatory mediator. Huntington's disease is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities, in which oxidative stress has been suggested as a possible pathogenic mechanism. In the present work we have investigated levels of hemoglobin and markers of oxidative damage, including the heme- and radical-scavenger alpha1-microglobulin, in plasma and urine samples from two separate sample cohorts, including controls, premanifest gene carriers and subjects at different stages of Huntington's disease. The results show statistically significant increased levels of hemoglobin and alpha1-microglobulin in Huntington's disease urine samples. Interestingly, urine hemoglobin levels correlate with clinical severity. The results suggest that hemolysis may be linked to the pathogenesis of Huntington's disease and that assay of hemoglobin and alpha1-microglobulin may provide biomarkers that are linked to biologically relevant processes.},
  author       = {Gram, Magnus and Davidsson, Sara and Muhammad, Zara Din and Lahiri, Nayana and Tabrizi, Sarah J and Åkerström, Bo and Björkqvist, Maria},
  issn         = {1945-0508},
  language     = {eng},
  pages        = {950--957},
  publisher    = {Frontiers},
  series       = {Frontiers in Bioscience (Elite Edition)},
  title        = {Increased levels of hemoglobin and alpha1-microglobulin in Huntington's disease.},
  volume       = {4},
  year         = {2012},
}