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The problem of confounding in studies of the effect of maternal drug use on pregnancy outcome.

Källén, Bengt LU (2012) In Obstetrics and Gynecology International 2012.
Abstract
In most epidemilogical studies, the problem of confounding adds to the uncertainty in conclusions drawn. This is also true for studies on the effect of maternal drug use on birth defect risks. This paper describes various types of such confounders and discusses methods to identify and adjust for them. Such confounders can be found in maternal characteristics like age, parity, smoking, use of alcohol, and body mass index, subfertility, and previous pregnancies including previous birth of a malformed child, socioeconomy, race/ethnicity, or country of birth. Confounding by concomitant maternal drug use may occur. A geographical or seasonal confounding can exist. In rare instances, infant sex and multiple birth can appear as confounders. The... (More)
In most epidemilogical studies, the problem of confounding adds to the uncertainty in conclusions drawn. This is also true for studies on the effect of maternal drug use on birth defect risks. This paper describes various types of such confounders and discusses methods to identify and adjust for them. Such confounders can be found in maternal characteristics like age, parity, smoking, use of alcohol, and body mass index, subfertility, and previous pregnancies including previous birth of a malformed child, socioeconomy, race/ethnicity, or country of birth. Confounding by concomitant maternal drug use may occur. A geographical or seasonal confounding can exist. In rare instances, infant sex and multiple birth can appear as confounders. The most difficult problem to solve is often confounding by indication. The problem of confounding is less important for congenital malformations than for many other pregnancy outcomes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obstetrics and Gynecology International
volume
2012
publisher
Hindawi Publishing Corporation
external identifiers
  • pmid:22190949
ISSN
1687-9589
DOI
10.1155/2012/148616
language
English
LU publication?
yes
id
15df67c4-cf6b-4ab1-a1f5-1f5384136eb1 (old id 2273679)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22190949?dopt=Abstract
date added to LUP
2012-01-03 21:22:06
date last changed
2017-02-22 10:46:22
@article{15df67c4-cf6b-4ab1-a1f5-1f5384136eb1,
  abstract     = {In most epidemilogical studies, the problem of confounding adds to the uncertainty in conclusions drawn. This is also true for studies on the effect of maternal drug use on birth defect risks. This paper describes various types of such confounders and discusses methods to identify and adjust for them. Such confounders can be found in maternal characteristics like age, parity, smoking, use of alcohol, and body mass index, subfertility, and previous pregnancies including previous birth of a malformed child, socioeconomy, race/ethnicity, or country of birth. Confounding by concomitant maternal drug use may occur. A geographical or seasonal confounding can exist. In rare instances, infant sex and multiple birth can appear as confounders. The most difficult problem to solve is often confounding by indication. The problem of confounding is less important for congenital malformations than for many other pregnancy outcomes.},
  articleno    = {148616},
  author       = {Källén, Bengt},
  issn         = {1687-9589},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Obstetrics and Gynecology International},
  title        = {The problem of confounding in studies of the effect of maternal drug use on pregnancy outcome.},
  url          = {http://dx.doi.org/10.1155/2012/148616},
  volume       = {2012},
  year         = {2012},
}