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Proteome-based biomarkers in pancreatic cancer.

Sun, Chen LU ; Rosendahl, Ann LU ; Ansari, Daniel LU and Andersson, Roland LU (2011) In World Journal of Gastroenterology 17(44). p.4845-4852
Abstract
Pancreatic cancer, as a highly malignant cancer and the fourth cause of cancer-related death in world, is characterized by dismal prognosis, due to rapid disease progression, highly invasive tumour phenotype, and resistance to chemotherapy. Despite significant advances in treatment of the disease during the past decade, the survival rate is little improved. A contributory factor to the poor outcome is the lack of appropriate sensitive and specific biomarkers for early diagnosis. Furthermore, biomarkers for targeting, directing and assessing therapeutic intervention, as well as for detection of residual or recurrent cancer are also needed. Thus, the identification of adequate biomarkers in pancreatic cancer is of extreme importance.... (More)
Pancreatic cancer, as a highly malignant cancer and the fourth cause of cancer-related death in world, is characterized by dismal prognosis, due to rapid disease progression, highly invasive tumour phenotype, and resistance to chemotherapy. Despite significant advances in treatment of the disease during the past decade, the survival rate is little improved. A contributory factor to the poor outcome is the lack of appropriate sensitive and specific biomarkers for early diagnosis. Furthermore, biomarkers for targeting, directing and assessing therapeutic intervention, as well as for detection of residual or recurrent cancer are also needed. Thus, the identification of adequate biomarkers in pancreatic cancer is of extreme importance. Recently, accompanying the development of proteomic technology and devices, more and more potential biomarkers have appeared and are being reported. In this review, we provide an overview of the role of proteome-based biomarkers in pancreatic cancer, including tissue, serum, juice, urine and cell lines. We also discuss the possible mechanism and prospects in the future. That information hopefully might be helpful for further research in the field. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
World Journal of Gastroenterology
volume
17
issue
44
pages
4845 - 4852
publisher
WJG Press
external identifiers
  • wos:000298168800002
  • pmid:22171124
  • scopus:83155168484
ISSN
1007-9327
DOI
10.3748/wjg.v17.i44.4845
language
English
LU publication?
yes
id
8010d52a-728b-4f49-aedb-1b2875022ad3 (old id 2274012)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22171124?dopt=Abstract
date added to LUP
2012-01-03 19:45:48
date last changed
2017-07-23 04:55:13
@article{8010d52a-728b-4f49-aedb-1b2875022ad3,
  abstract     = {Pancreatic cancer, as a highly malignant cancer and the fourth cause of cancer-related death in world, is characterized by dismal prognosis, due to rapid disease progression, highly invasive tumour phenotype, and resistance to chemotherapy. Despite significant advances in treatment of the disease during the past decade, the survival rate is little improved. A contributory factor to the poor outcome is the lack of appropriate sensitive and specific biomarkers for early diagnosis. Furthermore, biomarkers for targeting, directing and assessing therapeutic intervention, as well as for detection of residual or recurrent cancer are also needed. Thus, the identification of adequate biomarkers in pancreatic cancer is of extreme importance. Recently, accompanying the development of proteomic technology and devices, more and more potential biomarkers have appeared and are being reported. In this review, we provide an overview of the role of proteome-based biomarkers in pancreatic cancer, including tissue, serum, juice, urine and cell lines. We also discuss the possible mechanism and prospects in the future. That information hopefully might be helpful for further research in the field.},
  author       = {Sun, Chen and Rosendahl, Ann and Ansari, Daniel and Andersson, Roland},
  issn         = {1007-9327},
  language     = {eng},
  number       = {44},
  pages        = {4845--4852},
  publisher    = {WJG Press},
  series       = {World Journal of Gastroenterology},
  title        = {Proteome-based biomarkers in pancreatic cancer.},
  url          = {http://dx.doi.org/10.3748/wjg.v17.i44.4845},
  volume       = {17},
  year         = {2011},
}