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Effects of B(1) inhomogeneity correction for three-dimensional variable flip angle T(1) measurements in hip dGEMRIC at 3 T and 1.5 T.

Siversson, Carl LU ; Chan, Jenny; Tiderius, Carl Johan LU ; Mamisch, Tallal Charles; Jellus, Vladimir; Svensson, Jonas LU and Kim, Young-Jo (2012) In Magnetic Resonance in Medicine 67(6). p.1776-1781
Abstract
Delayed gadolinium-enhanced MRI of cartilage is a technique for studying the development of osteoarthritis using quantitative T(1) measurements. Three-dimensional variable flip angle is a promising method for performing such measurements rapidly, by using two successive spoiled gradient echo sequences with different excitation pulse flip angles. However, the three-dimensional variable flip angle method is very sensitive to inhomogeneities in the transmitted B(1) field in vivo. In this study, a method for correcting for such inhomogeneities, using an additional B(1) mapping spin-echo sequence, was evaluated. Phantom studies concluded that three-dimensional variable flip angle with B(1) correction calculates accurate T(1) values also in... (More)
Delayed gadolinium-enhanced MRI of cartilage is a technique for studying the development of osteoarthritis using quantitative T(1) measurements. Three-dimensional variable flip angle is a promising method for performing such measurements rapidly, by using two successive spoiled gradient echo sequences with different excitation pulse flip angles. However, the three-dimensional variable flip angle method is very sensitive to inhomogeneities in the transmitted B(1) field in vivo. In this study, a method for correcting for such inhomogeneities, using an additional B(1) mapping spin-echo sequence, was evaluated. Phantom studies concluded that three-dimensional variable flip angle with B(1) correction calculates accurate T(1) values also in areas with high B(1) deviation. Retrospective analysis of in vivo hip delayed gadolinium-enhanced MRI of cartilage data from 40 subjects showed the difference between three-dimensional variable flip angle with and without B(1) correction to be generally two to three times higher at 3 T than at 1.5 T. In conclusion, the B(1) variations should always be taken into account, both at 1.5 T and at 3 T. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
B1 correction, T1 mapping, dGEMRIC, cartilage
in
Magnetic Resonance in Medicine
volume
67
issue
6
pages
1776 - 1781
publisher
Wiley Online Library
external identifiers
  • wos:000304086000030
  • pmid:22135218
  • scopus:84861226958
ISSN
1522-2594
DOI
10.1002/mrm.23150
language
English
LU publication?
yes
id
9069351d-c352-4c03-8cc4-dd340f987de2 (old id 2274657)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22135218?dopt=Abstract
date added to LUP
2012-01-02 13:13:01
date last changed
2017-03-26 03:07:23
@article{9069351d-c352-4c03-8cc4-dd340f987de2,
  abstract     = {Delayed gadolinium-enhanced MRI of cartilage is a technique for studying the development of osteoarthritis using quantitative T(1) measurements. Three-dimensional variable flip angle is a promising method for performing such measurements rapidly, by using two successive spoiled gradient echo sequences with different excitation pulse flip angles. However, the three-dimensional variable flip angle method is very sensitive to inhomogeneities in the transmitted B(1) field in vivo. In this study, a method for correcting for such inhomogeneities, using an additional B(1) mapping spin-echo sequence, was evaluated. Phantom studies concluded that three-dimensional variable flip angle with B(1) correction calculates accurate T(1) values also in areas with high B(1) deviation. Retrospective analysis of in vivo hip delayed gadolinium-enhanced MRI of cartilage data from 40 subjects showed the difference between three-dimensional variable flip angle with and without B(1) correction to be generally two to three times higher at 3 T than at 1.5 T. In conclusion, the B(1) variations should always be taken into account, both at 1.5 T and at 3 T. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc.},
  author       = {Siversson, Carl and Chan, Jenny and Tiderius, Carl Johan and Mamisch, Tallal Charles and Jellus, Vladimir and Svensson, Jonas and Kim, Young-Jo},
  issn         = {1522-2594},
  keyword      = {B1 correction,T1 mapping,dGEMRIC,cartilage},
  language     = {eng},
  number       = {6},
  pages        = {1776--1781},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Effects of B(1) inhomogeneity correction for three-dimensional variable flip angle T(1) measurements in hip dGEMRIC at 3 T and 1.5 T.},
  url          = {http://dx.doi.org/10.1002/mrm.23150},
  volume       = {67},
  year         = {2012},
}