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Mortality and Inherited Thrombophilia: results from the European Prospective Cohort on Thrombophilia (EPCOT).

Pabinger, I; Vossen, C Y; Lang, J; Conard, J; García-Dabrio, M C; Miesbach, W; Legnani, C; Svensson, Peter LU ; Kaider, A and Rosendaal, F R (2012) In Journal of Thrombosis and Haemostasis 10(2). p.217-222
Abstract
Background: Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies. Objective: We aimed to assess mortality in individuals with known thrombophilia with and without a history of thrombosis in comparison to a control group. Patients/Methods: The European Prospective Cohort on Thrombophilia (EPCOT) study is a prospective multi-centre observational study performed to assess the risk of thrombosis in persons with inherited thrombophilia. In an extension of this study the vital status was assessed in 1,240 individuals with thrombophilia (mean age 40.9 years, 59% women, 196 with antithrombin-, 341 with protein C-, 276 with protein S-deficiency, 330 with factor V Leiden and 97 with... (More)
Background: Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies. Objective: We aimed to assess mortality in individuals with known thrombophilia with and without a history of thrombosis in comparison to a control group. Patients/Methods: The European Prospective Cohort on Thrombophilia (EPCOT) study is a prospective multi-centre observational study performed to assess the risk of thrombosis in persons with inherited thrombophilia. In an extension of this study the vital status was assessed in 1,240 individuals with thrombophilia (mean age 40.9 years, 59% women, 196 with antithrombin-, 341 with protein C-, 276 with protein S-deficiency, 330 with factor V Leiden and 97 with combined defects, 62% with a VT history) and 875 controls (mean age 42.5 years, 48% women, 7% with a VT history). Results: Seventy-two individuals with thrombophilia and 45 controls died during follow-up. The risk of death, adjusted for sex, thrombosis-history and centre, was not associated with thrombophilia (hazard ratio (HR) thrombophilia individuals versus controls: 1.09, 95% confidence interval (CI) 0.66-1.78). When individuals with thrombophilia were evaluated separately, a history of thrombosis was not associated with mortality: the risk of death after adjustment for sex, anticoagulation and center was HR 0.79 (95% CI 0.41-1.54). Conclusions: No increased risk of death in individuals with thrombophilia, not even in those with a history of thrombosis, was observed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
deep vein thrombosis mortality, pulmonary embolism, survival, thrombophilia, venous thromboembolism
in
Journal of Thrombosis and Haemostasis
volume
10
issue
2
pages
217 - 222
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000299779500006
  • pmid:22128841
  • scopus:84856554503
ISSN
1538-7933
DOI
10.1111/j.1538-7836.2011.04573.x
language
English
LU publication?
yes
id
44fb4e11-0d72-4222-a5cb-9c1a2b5906e0 (old id 2274784)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22128841?dopt=Abstract
date added to LUP
2012-01-02 11:27:33
date last changed
2017-11-05 03:24:21
@article{44fb4e11-0d72-4222-a5cb-9c1a2b5906e0,
  abstract     = {Background: Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies. Objective: We aimed to assess mortality in individuals with known thrombophilia with and without a history of thrombosis in comparison to a control group. Patients/Methods: The European Prospective Cohort on Thrombophilia (EPCOT) study is a prospective multi-centre observational study performed to assess the risk of thrombosis in persons with inherited thrombophilia. In an extension of this study the vital status was assessed in 1,240 individuals with thrombophilia (mean age 40.9 years, 59% women, 196 with antithrombin-, 341 with protein C-, 276 with protein S-deficiency, 330 with factor V Leiden and 97 with combined defects, 62% with a VT history) and 875 controls (mean age 42.5 years, 48% women, 7% with a VT history). Results: Seventy-two individuals with thrombophilia and 45 controls died during follow-up. The risk of death, adjusted for sex, thrombosis-history and centre, was not associated with thrombophilia (hazard ratio (HR) thrombophilia individuals versus controls: 1.09, 95% confidence interval (CI) 0.66-1.78). When individuals with thrombophilia were evaluated separately, a history of thrombosis was not associated with mortality: the risk of death after adjustment for sex, anticoagulation and center was HR 0.79 (95% CI 0.41-1.54). Conclusions: No increased risk of death in individuals with thrombophilia, not even in those with a history of thrombosis, was observed.},
  author       = {Pabinger, I and Vossen, C Y and Lang, J and Conard, J and García-Dabrio, M C and Miesbach, W and Legnani, C and Svensson, Peter and Kaider, A and Rosendaal, F R},
  issn         = {1538-7933},
  keyword      = {deep vein thrombosis mortality,pulmonary embolism,survival,thrombophilia,venous thromboembolism},
  language     = {eng},
  number       = {2},
  pages        = {217--222},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Journal of Thrombosis and Haemostasis},
  title        = {Mortality and Inherited Thrombophilia: results from the European Prospective Cohort on Thrombophilia (EPCOT).},
  url          = {http://dx.doi.org/10.1111/j.1538-7836.2011.04573.x},
  volume       = {10},
  year         = {2012},
}