Radiologisk och histologisk bild för en ökad förståelse vid covid-19
Mari Svensson, Ann ; Hansen, Tomas ; Nyren, Sven ; Csatlós, Martin and Brunnström, Hans LU
(2020)
In Lakartidningen
117.
- Abstract
We here describe the current knowledge about the radiologic and histologic pulmonary features of covid-19, caused by SARS-CoV-2, and present lung histology from a case with fatal disease. Initial findings on computed tomography (CT) typically include peripheral multifocal bilateral ground-glass opacities, and correspondingly microscopic alveolar edema. This is followed by peripheral consolidations with air bronchogram and perilobular pattern on CT, signs of organizing pneumonia, corresponding to loose (potentially reversible) fibrosis. The posterior parts of the lungs and the lower lobes are typically more markedly affected. In severe disease with acute respiratory distress syndrome, thickened interlobular septa and crazy paving pattern... (More)
We here describe the current knowledge about the radiologic and histologic pulmonary features of covid-19, caused by SARS-CoV-2, and present lung histology from a case with fatal disease. Initial findings on computed tomography (CT) typically include peripheral multifocal bilateral ground-glass opacities, and correspondingly microscopic alveolar edema. This is followed by peripheral consolidations with air bronchogram and perilobular pattern on CT, signs of organizing pneumonia, corresponding to loose (potentially reversible) fibrosis. The posterior parts of the lungs and the lower lobes are typically more markedly affected. In severe disease with acute respiratory distress syndrome, thickened interlobular septa and crazy paving pattern appear on CT, which corresponds to histologic diffuse alveolar damage with, depending on the stage of the disease, features such as edema, hyaline membranes, reactive epithelium, inflammation, and fibrosis.
(Less)
- author
- Mari Svensson, Ann
; Hansen, Tomas
; Nyren, Sven
; Csatlós, Martin
and Brunnström, Hans
LU
- organization
- alternative title
- Covid-19 - radiologic and histologic features
- publishing date
- 2020-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Lakartidningen
- volume
- 117
- publisher
- Swedish Medical Association
- external identifiers
-
- pmid:32484232
- scopus:85085854550
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- 227ee472-d785-4255-90f5-5ce1182d13f9
- alternative location
- https://lakartidningen.se/wp-content/uploads/2020/05/20086.pdf
- date added to LUP
- 2021-01-14 08:48:50
- date last changed
- 2024-04-03 23:13:21
@misc{227ee472-d785-4255-90f5-5ce1182d13f9,
abstract = {{<p>We here describe the current knowledge about the radiologic and histologic pulmonary features of covid-19, caused by SARS-CoV-2, and present lung histology from a case with fatal disease. Initial findings on computed tomography (CT) typically include peripheral multifocal bilateral ground-glass opacities, and correspondingly microscopic alveolar edema. This is followed by peripheral consolidations with air bronchogram and perilobular pattern on CT, signs of organizing pneumonia, corresponding to loose (potentially reversible) fibrosis. The posterior parts of the lungs and the lower lobes are typically more markedly affected. In severe disease with acute respiratory distress syndrome, thickened interlobular septa and crazy paving pattern appear on CT, which corresponds to histologic diffuse alveolar damage with, depending on the stage of the disease, features such as edema, hyaline membranes, reactive epithelium, inflammation, and fibrosis.</p>}},
author = {{Mari Svensson, Ann and Hansen, Tomas and Nyren, Sven and Csatlós, Martin and Brunnström, Hans}},
issn = {{0023-7205}},
language = {{swe}},
month = {{06}},
publisher = {{Swedish Medical Association}},
series = {{Lakartidningen}},
title = {{Radiologisk och histologisk bild för en ökad förståelse vid covid-19}},
url = {{https://lakartidningen.se/wp-content/uploads/2020/05/20086.pdf}},
volume = {{117}},
year = {{2020}},
}