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Association of brain tumours with other neoplasms in families

Hemminki, K LU and Li, Xinjun LU (2004) In European Journal of Cancer 40(2). p.9-253
Abstract

We used the nationwide Swedish Family-Cancer Database to analyse the association of histology-specific brain tumours with other cancers in family members. Among 0-68-year-old offspring, 9414 patients with brain tumours were identified from 1961 to 2000, of whom, 3387 parents were diagnosed with any primary neoplasm. Astrocytoma, meningioma and neurinoma were the main histological types. Increased standardised incidence ratios (SIRs) were found for brain tumours in association with cancers at sites that are known features in recognised syndromes, such as haemangioblastoma and renal cancer in von Hippel-Lindau disease. In addition, an association between astrocytoma and melanoma was recognised. Among as yet unknown clustering, neurinoma... (More)

We used the nationwide Swedish Family-Cancer Database to analyse the association of histology-specific brain tumours with other cancers in family members. Among 0-68-year-old offspring, 9414 patients with brain tumours were identified from 1961 to 2000, of whom, 3387 parents were diagnosed with any primary neoplasm. Astrocytoma, meningioma and neurinoma were the main histological types. Increased standardised incidence ratios (SIRs) were found for brain tumours in association with cancers at sites that are known features in recognised syndromes, such as haemangioblastoma and renal cancer in von Hippel-Lindau disease. In addition, an association between astrocytoma and melanoma was recognised. Among as yet unknown clustering, neurinoma was associated with testicular cancer and myeloma; meningioma was associated with cervical cancer; astrocytoma was associated with prostate cancer; ependymoma was associated with breast cancer. Although some of these may feature a true tumour cluster, they need to be confirmed in another setting.

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author
publishing date
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publication status
published
subject
keywords
Adolescent, Adult, Aged, Brain Neoplasms/epidemiology, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Middle Aged, Neoplasms/epidemiology, Pedigree, Risk Factors, Sweden/epidemiology
in
European Journal of Cancer
volume
40
issue
2
pages
7 pages
publisher
IFAC & Elsevier Ltd.
external identifiers
  • scopus:0347915530
ISSN
0959-8049
DOI
10.1016/j.ejca.2003.08.018
language
English
LU publication?
no
id
2284ba99-19d3-44fb-ac90-eb3af36a191e
date added to LUP
2019-01-30 11:45:53
date last changed
2019-03-12 04:20:26
@article{2284ba99-19d3-44fb-ac90-eb3af36a191e,
  abstract     = {<p>We used the nationwide Swedish Family-Cancer Database to analyse the association of histology-specific brain tumours with other cancers in family members. Among 0-68-year-old offspring, 9414 patients with brain tumours were identified from 1961 to 2000, of whom, 3387 parents were diagnosed with any primary neoplasm. Astrocytoma, meningioma and neurinoma were the main histological types. Increased standardised incidence ratios (SIRs) were found for brain tumours in association with cancers at sites that are known features in recognised syndromes, such as haemangioblastoma and renal cancer in von Hippel-Lindau disease. In addition, an association between astrocytoma and melanoma was recognised. Among as yet unknown clustering, neurinoma was associated with testicular cancer and myeloma; meningioma was associated with cervical cancer; astrocytoma was associated with prostate cancer; ependymoma was associated with breast cancer. Although some of these may feature a true tumour cluster, they need to be confirmed in another setting.</p>},
  author       = {Hemminki, K and Li, Xinjun},
  issn         = {0959-8049},
  keyword      = {Adolescent,Adult,Aged,Brain Neoplasms/epidemiology,Child,Child, Preschool,Humans,Infant,Infant, Newborn,Middle Aged,Neoplasms/epidemiology,Pedigree,Risk Factors,Sweden/epidemiology},
  language     = {eng},
  number       = {2},
  pages        = {9--253},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Association of brain tumours with other neoplasms in families},
  url          = {http://dx.doi.org/10.1016/j.ejca.2003.08.018},
  volume       = {40},
  year         = {2004},
}