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Complement at the crossroads of inflammation and metabolism : implications for diabetes and metabolic functions

Dandavate, Vaishnavi LU orcid ; Blom, Anna M. LU orcid and King, Ben C. LU orcid (2025) In Immunobiology 230(6).
Abstract

Diabetes is a growing global problem, with hundreds of millions of people living with the disease worldwide. Diabetes can be divided into two major subtypes, autoimmune type 1 diabetes (T1D), and type 2 diabetes (T2D), which has stronger causal links in obesity, lifestyle, and age. Although immunity and inflammation are clearly defined in T1D, it is also understood that inflammation has a role in metabolic dysregulation in T2D, inducing insulin resistance as well as affecting β-cell function, survival, and therefore insulin secretion. Cytokines and other inflammatory mediators can affect function of cells important for metabolism, most studied in adipose tissue, muscle, and pancreatic islets. Similarly, evidence shows that complement... (More)

Diabetes is a growing global problem, with hundreds of millions of people living with the disease worldwide. Diabetes can be divided into two major subtypes, autoimmune type 1 diabetes (T1D), and type 2 diabetes (T2D), which has stronger causal links in obesity, lifestyle, and age. Although immunity and inflammation are clearly defined in T1D, it is also understood that inflammation has a role in metabolic dysregulation in T2D, inducing insulin resistance as well as affecting β-cell function, survival, and therefore insulin secretion. Cytokines and other inflammatory mediators can affect function of cells important for metabolism, most studied in adipose tissue, muscle, and pancreatic islets. Similarly, evidence shows that complement can also have positive roles in metabolic homeostasis in adipose tissue and pancreatic islets. This review will give an introduction to this field, with focus on established and emerging roles of the complement system, an arm of humoral innate immunity that has been found to have roles in metabolic homeostasis.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Complement, Diabetes, Metabolism
in
Immunobiology
volume
230
issue
6
article number
153113
publisher
Elsevier
external identifiers
  • pmid:40967136
  • scopus:105020438435
ISSN
0171-2985
DOI
10.1016/j.imbio.2025.153113
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/
id
2287a510-604a-49d8-9d77-cfcaa46b4d6d
date added to LUP
2025-12-15 16:00:27
date last changed
2025-12-15 16:00:56
@article{2287a510-604a-49d8-9d77-cfcaa46b4d6d,
  abstract     = {{<p>Diabetes is a growing global problem, with hundreds of millions of people living with the disease worldwide. Diabetes can be divided into two major subtypes, autoimmune type 1 diabetes (T1D), and type 2 diabetes (T2D), which has stronger causal links in obesity, lifestyle, and age. Although immunity and inflammation are clearly defined in T1D, it is also understood that inflammation has a role in metabolic dysregulation in T2D, inducing insulin resistance as well as affecting β-cell function, survival, and therefore insulin secretion. Cytokines and other inflammatory mediators can affect function of cells important for metabolism, most studied in adipose tissue, muscle, and pancreatic islets. Similarly, evidence shows that complement can also have positive roles in metabolic homeostasis in adipose tissue and pancreatic islets. This review will give an introduction to this field, with focus on established and emerging roles of the complement system, an arm of humoral innate immunity that has been found to have roles in metabolic homeostasis.</p>}},
  author       = {{Dandavate, Vaishnavi and Blom, Anna M. and King, Ben C.}},
  issn         = {{0171-2985}},
  keywords     = {{Complement; Diabetes; Metabolism}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{Elsevier}},
  series       = {{Immunobiology}},
  title        = {{Complement at the crossroads of inflammation and metabolism : implications for diabetes and metabolic functions}},
  url          = {{http://dx.doi.org/10.1016/j.imbio.2025.153113}},
  doi          = {{10.1016/j.imbio.2025.153113}},
  volume       = {{230}},
  year         = {{2025}},
}