Adherence to isoniazid preventive therapy in children exposed to tuberculosis: a prospective study from Guinea-Bissau
(2011) In The International Journal of Tuberculosis and Lung Disease 15(12). p.1637-1642- Abstract
- OBJECTIVE: To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home. METHODS: Children were enrolled on IPT if they were aged <= 5 years or 5-15 years and presented a tuberculin skin test induration of >= 1.0 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence. RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identified, 1895 (72%) were evaluated for eligibility for IPT, and 820 were... (More)
- OBJECTIVE: To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home. METHODS: Children were enrolled on IPT if they were aged <= 5 years or 5-15 years and presented a tuberculin skin test induration of >= 1.0 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence. RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identified, 1895 (72%) were evaluated for eligibility for IPT, and 820 were enrolled in the study: 609 were aged 5 years and 211 aged 5-15 years. A total of 79% of the prescribed doses were taken, with 65% of the children taking >80% of their doses. In all, 51% completed more than 6 consecutive months of IPT. CONCLUSION: Overall adherence to IPT was better than previously reported from TB-endemic areas, with 76% of the children completing at least 6 months of treatment, with more than 80% adherence. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2291777
- author
- Gomes, V. F. ; Wejse, C. ; Oliveira, I. ; Andersen, A. ; Vieira, F. J. ; Carlos, L. J. ; Vieira, C. S. ; Aaby, P. and Gustafson, Per LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- latent TB, isoniazid preventive therapy, TB exposure, adherence, Guinea-Bissau
- in
- The International Journal of Tuberculosis and Lung Disease
- volume
- 15
- issue
- 12
- pages
- 1637 - 1642
- publisher
- International Union against Tuberculosis and Lung Disease
- external identifiers
-
- wos:000297602600015
- scopus:81455150131
- pmid:22118171
- ISSN
- 1815-7920
- DOI
- 10.5588/ijtld.10.0558
- language
- English
- LU publication?
- yes
- id
- 617fbb14-2301-4377-b7f0-2a4fce5d20fe (old id 2291777)
- date added to LUP
- 2016-04-01 10:50:36
- date last changed
- 2022-03-12 17:34:11
@article{617fbb14-2301-4377-b7f0-2a4fce5d20fe, abstract = {{OBJECTIVE: To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home. METHODS: Children were enrolled on IPT if they were aged <= 5 years or 5-15 years and presented a tuberculin skin test induration of >= 1.0 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence. RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identified, 1895 (72%) were evaluated for eligibility for IPT, and 820 were enrolled in the study: 609 were aged 5 years and 211 aged 5-15 years. A total of 79% of the prescribed doses were taken, with 65% of the children taking >80% of their doses. In all, 51% completed more than 6 consecutive months of IPT. CONCLUSION: Overall adherence to IPT was better than previously reported from TB-endemic areas, with 76% of the children completing at least 6 months of treatment, with more than 80% adherence.}}, author = {{Gomes, V. F. and Wejse, C. and Oliveira, I. and Andersen, A. and Vieira, F. J. and Carlos, L. J. and Vieira, C. S. and Aaby, P. and Gustafson, Per}}, issn = {{1815-7920}}, keywords = {{latent TB; isoniazid preventive therapy; TB exposure; adherence; Guinea-Bissau}}, language = {{eng}}, number = {{12}}, pages = {{1637--1642}}, publisher = {{International Union against Tuberculosis and Lung Disease}}, series = {{The International Journal of Tuberculosis and Lung Disease}}, title = {{Adherence to isoniazid preventive therapy in children exposed to tuberculosis: a prospective study from Guinea-Bissau}}, url = {{http://dx.doi.org/10.5588/ijtld.10.0558}}, doi = {{10.5588/ijtld.10.0558}}, volume = {{15}}, year = {{2011}}, }