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Adherence to isoniazid preventive therapy in children exposed to tuberculosis: a prospective study from Guinea-Bissau

Gomes, V. F.; Wejse, C.; Oliveira, I.; Andersen, A.; Vieira, F. J.; Carlos, L. J.; Vieira, C. S.; Aaby, P. and Gustafson, Per LU (2011) In The International Journal of Tuberculosis and Lung Disease 15(12). p.1637-1642
Abstract
OBJECTIVE: To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home. METHODS: Children were enrolled on IPT if they were aged <= 5 years or 5-15 years and presented a tuberculin skin test induration of >= 1.0 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence. RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identified, 1895 (72%) were evaluated for eligibility for IPT, and 820 were... (More)
OBJECTIVE: To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home. METHODS: Children were enrolled on IPT if they were aged <= 5 years or 5-15 years and presented a tuberculin skin test induration of >= 1.0 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence. RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identified, 1895 (72%) were evaluated for eligibility for IPT, and 820 were enrolled in the study: 609 were aged 5 years and 211 aged 5-15 years. A total of 79% of the prescribed doses were taken, with 65% of the children taking >80% of their doses. In all, 51% completed more than 6 consecutive months of IPT. CONCLUSION: Overall adherence to IPT was better than previously reported from TB-endemic areas, with 76% of the children completing at least 6 months of treatment, with more than 80% adherence. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
latent TB, isoniazid preventive therapy, TB exposure, adherence, Guinea-Bissau
in
The International Journal of Tuberculosis and Lung Disease
volume
15
issue
12
pages
1637 - 1642
publisher
International Union against Tuberculosis and Lung Disease
external identifiers
  • wos:000297602600015
  • scopus:81455150131
ISSN
1815-7920
DOI
10.5588/ijtld.10.0558
language
English
LU publication?
yes
id
617fbb14-2301-4377-b7f0-2a4fce5d20fe (old id 2291777)
date added to LUP
2012-01-11 15:51:46
date last changed
2017-11-12 03:12:51
@article{617fbb14-2301-4377-b7f0-2a4fce5d20fe,
  abstract     = {OBJECTIVE: To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home. METHODS: Children were enrolled on IPT if they were aged &lt;= 5 years or 5-15 years and presented a tuberculin skin test induration of &gt;= 1.0 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence. RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identified, 1895 (72%) were evaluated for eligibility for IPT, and 820 were enrolled in the study: 609 were aged 5 years and 211 aged 5-15 years. A total of 79% of the prescribed doses were taken, with 65% of the children taking &gt;80% of their doses. In all, 51% completed more than 6 consecutive months of IPT. CONCLUSION: Overall adherence to IPT was better than previously reported from TB-endemic areas, with 76% of the children completing at least 6 months of treatment, with more than 80% adherence.},
  author       = {Gomes, V. F. and Wejse, C. and Oliveira, I. and Andersen, A. and Vieira, F. J. and Carlos, L. J. and Vieira, C. S. and Aaby, P. and Gustafson, Per},
  issn         = {1815-7920},
  keyword      = {latent TB,isoniazid preventive therapy,TB exposure,adherence,Guinea-Bissau},
  language     = {eng},
  number       = {12},
  pages        = {1637--1642},
  publisher    = {International Union against Tuberculosis and Lung Disease},
  series       = {The International Journal of Tuberculosis and Lung Disease},
  title        = {Adherence to isoniazid preventive therapy in children exposed to tuberculosis: a prospective study from Guinea-Bissau},
  url          = {http://dx.doi.org/10.5588/ijtld.10.0558},
  volume       = {15},
  year         = {2011},
}