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Low serum concentration of sulfatide and presence of sulfated lactosylceramid are associated with Type 2 diabetes. The Skaraborg Project

Buschard, K; Fredman, P; Bog-Hansen, E; Blomqvist, M; Hedner, J; Råstam, Lennart LU and Lindblad, Ulf LU (2005) In Diabetic Medicine 22(9). p.1190-1198
Abstract
Aims The glycosphingolipid sulfatide (sulfated galactosyl-ceramide) increases exocytosis of beta-cell secretory granules, activates K-ATP-channels and is thereby able to influence insulin secretion through its presence in the islets. A closely related compound, sulfated lactosylceramide (sulf-lac-cer), is present in the islets during fetal and neonatal life when, as in Type 2 diabetes, insulin is secreted autonomically without the usual first phase response to glucose. The aim was to examine whether serum concentrations of these glycolipids are associated with Type 2 diabetes. Methods A case-control study, comprising 286 women and 283 men, was designed using a population-based sample of patients with Type 2 diabetes and a population... (More)
Aims The glycosphingolipid sulfatide (sulfated galactosyl-ceramide) increases exocytosis of beta-cell secretory granules, activates K-ATP-channels and is thereby able to influence insulin secretion through its presence in the islets. A closely related compound, sulfated lactosylceramide (sulf-lac-cer), is present in the islets during fetal and neonatal life when, as in Type 2 diabetes, insulin is secreted autonomically without the usual first phase response to glucose. The aim was to examine whether serum concentrations of these glycolipids are associated with Type 2 diabetes. Methods A case-control study, comprising 286 women and 283 men, was designed using a population-based sample of patients with Type 2 diabetes and a population survey. Results Low serum concentrations of sulfatide were associated with Type 2 diabetes, independent of traditional risk factors for diabetes in a sex-specific analysis: odds ratio (OR) 2.1 (95% confidence interval 1.1, 3.9) in men, and 2.3 (1.2, 4.3) in women, comparing the lowest and the highest tertiles. Type 2 diabetes was also associated with detectable amounts of sulf-lac-cer in serum: OR 1.7 (0.9, 3.4) in men, and 7.6 (3.8, 15.2) in women. After adjustment for confounding from other diabetes risk factors, these associations remained basically unchanged. The connections between sulfatide and Type 2 diabetes, and sulf-lac-cer and Type 2 diabetes were independent of each other. Insulin resistance (HOMA-IR) was negatively correlated with sulfatide concentration and positively correlated with sulf-lac-cer (both P < 0.0001, independently). Conclusions We report a new, robust and highly significant independent association between Type 2 diabetes and serum concentrations of sulfatide in both sexes, and sulf-lac-cer in females. The associations were also independent of other known diabetes risk factors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sulf-lac-cer sulfatide, insulin resistance, Type 2 diabetes, sulfated lactosylceramide
in
Diabetic Medicine
volume
22
issue
9
pages
1190 - 1198
publisher
Wiley-Blackwell
external identifiers
  • pmid:16108848
  • wos:000231224800012
  • scopus:24044504407
ISSN
1464-5491
DOI
10.1111/j.1464-5491.2005.01613.x
language
English
LU publication?
yes
id
3455daae-1836-4c2f-b117-00a10973a150 (old id 229306)
date added to LUP
2007-08-16 12:40:19
date last changed
2017-01-22 04:01:57
@article{3455daae-1836-4c2f-b117-00a10973a150,
  abstract     = {Aims The glycosphingolipid sulfatide (sulfated galactosyl-ceramide) increases exocytosis of beta-cell secretory granules, activates K-ATP-channels and is thereby able to influence insulin secretion through its presence in the islets. A closely related compound, sulfated lactosylceramide (sulf-lac-cer), is present in the islets during fetal and neonatal life when, as in Type 2 diabetes, insulin is secreted autonomically without the usual first phase response to glucose. The aim was to examine whether serum concentrations of these glycolipids are associated with Type 2 diabetes. Methods A case-control study, comprising 286 women and 283 men, was designed using a population-based sample of patients with Type 2 diabetes and a population survey. Results Low serum concentrations of sulfatide were associated with Type 2 diabetes, independent of traditional risk factors for diabetes in a sex-specific analysis: odds ratio (OR) 2.1 (95% confidence interval 1.1, 3.9) in men, and 2.3 (1.2, 4.3) in women, comparing the lowest and the highest tertiles. Type 2 diabetes was also associated with detectable amounts of sulf-lac-cer in serum: OR 1.7 (0.9, 3.4) in men, and 7.6 (3.8, 15.2) in women. After adjustment for confounding from other diabetes risk factors, these associations remained basically unchanged. The connections between sulfatide and Type 2 diabetes, and sulf-lac-cer and Type 2 diabetes were independent of each other. Insulin resistance (HOMA-IR) was negatively correlated with sulfatide concentration and positively correlated with sulf-lac-cer (both P &lt; 0.0001, independently). Conclusions We report a new, robust and highly significant independent association between Type 2 diabetes and serum concentrations of sulfatide in both sexes, and sulf-lac-cer in females. The associations were also independent of other known diabetes risk factors.},
  author       = {Buschard, K and Fredman, P and Bog-Hansen, E and Blomqvist, M and Hedner, J and Råstam, Lennart and Lindblad, Ulf},
  issn         = {1464-5491},
  keyword      = {sulf-lac-cer sulfatide,insulin resistance,Type 2 diabetes,sulfated lactosylceramide},
  language     = {eng},
  number       = {9},
  pages        = {1190--1198},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetic Medicine},
  title        = {Low serum concentration of sulfatide and presence of sulfated lactosylceramid are associated with Type 2 diabetes. The Skaraborg Project},
  url          = {http://dx.doi.org/10.1111/j.1464-5491.2005.01613.x},
  volume       = {22},
  year         = {2005},
}