Core-needle biopsy performed by the cytopathologist : a technique to complement fine-needle aspiration of soft tissue and bone lesions
(2005) In Cancer 105(4). p.229-239- Abstract
BACKGROUND: Fine-needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of musculoskeletal lesions; and, in many patients, a definitive diagnosis can be rendered from aspiration smears alone. The main limitation of FNAC of soft tissue and bone neoplasms is in the evaluation of tissue architecture. In addition cytologic specimens are not always adequate for ancillary studies.
METHODS: A consecutive series of 130 patients with soft tissue and bone lesions was examined by core-needle biopsy (CNB) performed by a cytopathologist in conjunction with FNAC. The findings of this combined diagnostic approach were compared with histologic diagnoses made on surgical biopsies and resected specimens from 86 patients.... (More)
BACKGROUND: Fine-needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of musculoskeletal lesions; and, in many patients, a definitive diagnosis can be rendered from aspiration smears alone. The main limitation of FNAC of soft tissue and bone neoplasms is in the evaluation of tissue architecture. In addition cytologic specimens are not always adequate for ancillary studies.
METHODS: A consecutive series of 130 patients with soft tissue and bone lesions was examined by core-needle biopsy (CNB) performed by a cytopathologist in conjunction with FNAC. The findings of this combined diagnostic approach were compared with histologic diagnoses made on surgical biopsies and resected specimens from 86 patients. Adequate follow-up was available in all patients.
RESULTS: FNAC combined with CNB correctly could identify 77 of 78 malignant lesions and 50 of 52 benign lesions. Only seven patients underwent incisional biopsy. The tumor subtype was determined correctly in 30 of 39 patients (77%) and the malignancy grade was determined in 35 of 39 patients (90%) with primary soft tissue and bone sarcomas compared with the biopsy or operative specimens.
CONCLUSIONS: FNAC of musculoskeletal tumors/lesions complemented with CNB combined cytomorphology with tissue architecture and ancillary procedures. In the current study, obtaining FNAC as well as CNB at the same clinic visit and by the cytopathologist made preliminary diagnosis on the day of referral possible. This speeded diagnosis increased the number of correct diagnoses and usually enabled correct subtyping and malignancy grading of sarcomas.
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- author
- Domanski, Henryk A LU ; Åkerman, Måns LU ; Carlén, Birgitta LU ; Engellau, Jacob LU ; Gustafson, Pelle LU ; Jonsson, Kjell LU ; Mertens, Fredrik LU and Rydholm, Anders LU
- organization
- publishing date
- 2005-08-25
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Aged, Biopsy, Fine-Needle, Biopsy, Needle, Bone Diseases, Cytodiagnosis, Female, Humans, Lymphoma, Male, Sarcoma, Soft Tissue Neoplasms, Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- in
- Cancer
- volume
- 105
- issue
- 4
- pages
- 11 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:15918176
- wos:000231257200007
- scopus:23844461485
- pmid:15918176
- ISSN
- 1097-0142
- DOI
- 10.1002/cncr.21154
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Orthopaedics (Lund) (013028000), Oncology, MV (013035000), Pathology, (Lund) (013030000), Diagnostic Radiology, (Lund) (013038000), Division of Clinical Genetics (013022003)
- id
- c1ea2859-6c2a-40bb-9a59-a1f800669ee6 (old id 229372)
- date added to LUP
- 2016-04-01 12:10:11
- date last changed
- 2022-03-28 21:13:02
@article{c1ea2859-6c2a-40bb-9a59-a1f800669ee6,
abstract = {{<p>BACKGROUND: Fine-needle aspiration cytology (FNAC) is gaining increased popularity in the diagnosis of musculoskeletal lesions; and, in many patients, a definitive diagnosis can be rendered from aspiration smears alone. The main limitation of FNAC of soft tissue and bone neoplasms is in the evaluation of tissue architecture. In addition cytologic specimens are not always adequate for ancillary studies.</p><p>METHODS: A consecutive series of 130 patients with soft tissue and bone lesions was examined by core-needle biopsy (CNB) performed by a cytopathologist in conjunction with FNAC. The findings of this combined diagnostic approach were compared with histologic diagnoses made on surgical biopsies and resected specimens from 86 patients. Adequate follow-up was available in all patients.</p><p>RESULTS: FNAC combined with CNB correctly could identify 77 of 78 malignant lesions and 50 of 52 benign lesions. Only seven patients underwent incisional biopsy. The tumor subtype was determined correctly in 30 of 39 patients (77%) and the malignancy grade was determined in 35 of 39 patients (90%) with primary soft tissue and bone sarcomas compared with the biopsy or operative specimens.</p><p>CONCLUSIONS: FNAC of musculoskeletal tumors/lesions complemented with CNB combined cytomorphology with tissue architecture and ancillary procedures. In the current study, obtaining FNAC as well as CNB at the same clinic visit and by the cytopathologist made preliminary diagnosis on the day of referral possible. This speeded diagnosis increased the number of correct diagnoses and usually enabled correct subtyping and malignancy grading of sarcomas.</p>}},
author = {{Domanski, Henryk A and Åkerman, Måns and Carlén, Birgitta and Engellau, Jacob and Gustafson, Pelle and Jonsson, Kjell and Mertens, Fredrik and Rydholm, Anders}},
issn = {{1097-0142}},
keywords = {{Adult; Aged; Biopsy, Fine-Needle; Biopsy, Needle; Bone Diseases; Cytodiagnosis; Female; Humans; Lymphoma; Male; Sarcoma; Soft Tissue Neoplasms; Case Reports; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
month = {{08}},
number = {{4}},
pages = {{229--239}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Cancer}},
title = {{Core-needle biopsy performed by the cytopathologist : a technique to complement fine-needle aspiration of soft tissue and bone lesions}},
url = {{http://dx.doi.org/10.1002/cncr.21154}},
doi = {{10.1002/cncr.21154}},
volume = {{105}},
year = {{2005}},
}