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Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients

Knudsen, TB; Gustafson, Per LU ; Kronborg, G; Kristiansen, TB; Moestrup, SK; Nielsen, JO; Gomes, V; Aaby, P; Lisse, I and Moller, HJ, et al. (2005) In Clinical Microbiology and Infection 11(9). p.730-735
Abstract
Pre-treatment serum levels of sCD163 were measured in a cohort of 236 suspected tuberculosis (TB) cases from Guinea-Bissau, with a median follow-up period of 3.3 years (range 0-6.4 years). In 113 cases, the diagnosis of TB was verified by positive sputum microscopy and/or culture. Among the verified TB cases, a decreased survival rate was found in 27 patients with sCD163 levels above the upper reference limit (3.95 mu g/mL). The difference in survival was significant during TB treatment (log rank, p < 0.02) and after long-term follow-up (log rank, p < 0.001). The decrease in survival rate during TB treatment remained significant in a multivariate Cox model controlling for human immunodeficiency virus (HIV) status, age and gender,... (More)
Pre-treatment serum levels of sCD163 were measured in a cohort of 236 suspected tuberculosis (TB) cases from Guinea-Bissau, with a median follow-up period of 3.3 years (range 0-6.4 years). In 113 cases, the diagnosis of TB was verified by positive sputum microscopy and/or culture. Among the verified TB cases, a decreased survival rate was found in 27 patients with sCD163 levels above the upper reference limit (3.95 mu g/mL). The difference in survival was significant during TB treatment (log rank, p < 0.02) and after long-term follow-up (log rank, p < 0.001). The decrease in survival rate during TB treatment remained significant in a multivariate Cox model controlling for human immunodeficiency virus (HIV) status, age and gender, with a mortality increase of 1.19 (95% CI, 1.04-1.36) per mu g of sCD163, and a hazard ratio (HR) for sCD163 levels above the upper reference limit of 4.18 (95% CI, 1.06-16.4). The difference was not significant after excluding patients with concomitant HIV-1 and HIV-2 infection in Kaplan-Meier analyses (log rank, p 0.11). In contrast, the difference in survival remained significant in Kaplan-Meier analyses after long-term follow-up, even after excluding patients with concomitant HIV-1 and HIV-2 infection (log rank, p 0.002). In the Cox model, the mortality increase per mu g of sCD163 was 1.27 (95% CI, 1.14-1.40), with an HR for elevated sCD163 levels of 2.85 (95% CI, 1.44-5.63). The HRs for concomitant HIV-1 and HIV-2 infection were 6.92 (95% CI, 3.28-14.58) and 2.48 (95% CI, 1.09-5.67), respectively. Thus, sCD163 levels appeared to be an independent predictor of survival in verified TB patients. (Less)
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Contribution to journal
publication status
published
subject
keywords
survival, prognostic marker, CD163, human immunodeficiency virus, tuberculosis
in
Clinical Microbiology and Infection
volume
11
issue
9
pages
730 - 735
publisher
Wiley-Blackwell
external identifiers
  • wos:000231021900007
  • pmid:16104988
  • scopus:23844446662
ISSN
1469-0691
DOI
10.1111/j.1469-0691.2005.01229.x
language
English
LU publication?
yes
id
a404e6d1-d30b-4890-b237-73dbfe1b6618 (old id 229740)
date added to LUP
2007-08-22 11:02:31
date last changed
2017-05-21 03:31:23
@article{a404e6d1-d30b-4890-b237-73dbfe1b6618,
  abstract     = {Pre-treatment serum levels of sCD163 were measured in a cohort of 236 suspected tuberculosis (TB) cases from Guinea-Bissau, with a median follow-up period of 3.3 years (range 0-6.4 years). In 113 cases, the diagnosis of TB was verified by positive sputum microscopy and/or culture. Among the verified TB cases, a decreased survival rate was found in 27 patients with sCD163 levels above the upper reference limit (3.95 mu g/mL). The difference in survival was significant during TB treatment (log rank, p &lt; 0.02) and after long-term follow-up (log rank, p &lt; 0.001). The decrease in survival rate during TB treatment remained significant in a multivariate Cox model controlling for human immunodeficiency virus (HIV) status, age and gender, with a mortality increase of 1.19 (95% CI, 1.04-1.36) per mu g of sCD163, and a hazard ratio (HR) for sCD163 levels above the upper reference limit of 4.18 (95% CI, 1.06-16.4). The difference was not significant after excluding patients with concomitant HIV-1 and HIV-2 infection in Kaplan-Meier analyses (log rank, p 0.11). In contrast, the difference in survival remained significant in Kaplan-Meier analyses after long-term follow-up, even after excluding patients with concomitant HIV-1 and HIV-2 infection (log rank, p 0.002). In the Cox model, the mortality increase per mu g of sCD163 was 1.27 (95% CI, 1.14-1.40), with an HR for elevated sCD163 levels of 2.85 (95% CI, 1.44-5.63). The HRs for concomitant HIV-1 and HIV-2 infection were 6.92 (95% CI, 3.28-14.58) and 2.48 (95% CI, 1.09-5.67), respectively. Thus, sCD163 levels appeared to be an independent predictor of survival in verified TB patients.},
  author       = {Knudsen, TB and Gustafson, Per and Kronborg, G and Kristiansen, TB and Moestrup, SK and Nielsen, JO and Gomes, V and Aaby, P and Lisse, I and Moller, HJ and Eugen-Olsen, J},
  issn         = {1469-0691},
  keyword      = {survival,prognostic marker,CD163,human immunodeficiency virus,tuberculosis},
  language     = {eng},
  number       = {9},
  pages        = {730--735},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Microbiology and Infection},
  title        = {Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients},
  url          = {http://dx.doi.org/10.1111/j.1469-0691.2005.01229.x},
  volume       = {11},
  year         = {2005},
}