Icosahedral capsid formation by capsomer subunits and a semiflexible polyion
(2013) In RSC Advances 3(47). p.25258-25267- Abstract
- The role of the genome in the assembly of icosahedral viral capsids has been investigated by molecular dynamics simulation of a coarse-grained model, in which the capsomers carry explicit charges and the polynucleic acid is represented by a bead-spring chain. The co-assembly process was contrasted with the self-assembly of uncharged capsomers. In the co-assembly, the capsomers first associated to the polyion and then rearrange into a capsid, whereas the self-assembly proceeded through a spontaneous nucleation and growth of partial capsids. The polyion backbone stiffness was found to have a significant effect on the co-assembly process; polyions of intermediate flexibility gave the fastest and most faithful assembly process. Addition of a... (More)
- The role of the genome in the assembly of icosahedral viral capsids has been investigated by molecular dynamics simulation of a coarse-grained model, in which the capsomers carry explicit charges and the polynucleic acid is represented by a bead-spring chain. The co-assembly process was contrasted with the self-assembly of uncharged capsomers. In the co-assembly, the capsomers first associated to the polyion and then rearrange into a capsid, whereas the self-assembly proceeded through a spontaneous nucleation and growth of partial capsids. The polyion backbone stiffness was found to have a significant effect on the co-assembly process; polyions of intermediate flexibility gave the fastest and most faithful assembly process. Addition of a small amount of monovalent salt also improved both speed and fidelity of the co-assembly process. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4275359
- author
- Zhang, Ran LU ; Wernersson, Erik LU and Linse, Per LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- RSC Advances
- volume
- 3
- issue
- 47
- pages
- 25258 - 25267
- publisher
- Royal Society of Chemistry
- external identifiers
-
- wos:000327261000066
- scopus:84887843192
- ISSN
- 2046-2069
- DOI
- 10.1039/c3ra44533j
- language
- English
- LU publication?
- yes
- id
- 229efab5-1029-414b-ba66-2b122ae4db48 (old id 4275359)
- date added to LUP
- 2016-04-01 14:20:31
- date last changed
- 2022-03-21 23:28:37
@article{229efab5-1029-414b-ba66-2b122ae4db48,
abstract = {{The role of the genome in the assembly of icosahedral viral capsids has been investigated by molecular dynamics simulation of a coarse-grained model, in which the capsomers carry explicit charges and the polynucleic acid is represented by a bead-spring chain. The co-assembly process was contrasted with the self-assembly of uncharged capsomers. In the co-assembly, the capsomers first associated to the polyion and then rearrange into a capsid, whereas the self-assembly proceeded through a spontaneous nucleation and growth of partial capsids. The polyion backbone stiffness was found to have a significant effect on the co-assembly process; polyions of intermediate flexibility gave the fastest and most faithful assembly process. Addition of a small amount of monovalent salt also improved both speed and fidelity of the co-assembly process.}},
author = {{Zhang, Ran and Wernersson, Erik and Linse, Per}},
issn = {{2046-2069}},
language = {{eng}},
number = {{47}},
pages = {{25258--25267}},
publisher = {{Royal Society of Chemistry}},
series = {{RSC Advances}},
title = {{Icosahedral capsid formation by capsomer subunits and a semiflexible polyion}},
url = {{http://dx.doi.org/10.1039/c3ra44533j}},
doi = {{10.1039/c3ra44533j}},
volume = {{3}},
year = {{2013}},
}