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MZB Cell Development and Function

Spencer, Jo and Bemark, Mats LU orcid (2024)
Abstract
Marginal zone B cells (MZB cells) are innate like B cells that are predominantly located alongside memory B cells in the microanatomical region of the spleen of humans and mice termed the marginal zone. They circulate in humans but not mice, and in humans can be identified in blood and other lymphoid tissues, including the gut-associated lymphoid tissue, where they, as in spleen, form a zone surrounding the naïve B cells. Although MZB cells in mice and humans differ in their derivation and fine microanatomic and systemic distribution, they converge in function as the major B cell subset responding to T-independent type 2 antigens such as bacterial capsular polysaccharides. They are clinically relevant by providing rapid protection against... (More)
Marginal zone B cells (MZB cells) are innate like B cells that are predominantly located alongside memory B cells in the microanatomical region of the spleen of humans and mice termed the marginal zone. They circulate in humans but not mice, and in humans can be identified in blood and other lymphoid tissues, including the gut-associated lymphoid tissue, where they, as in spleen, form a zone surrounding the naïve B cells. Although MZB cells in mice and humans differ in their derivation and fine microanatomic and systemic distribution, they converge in function as the major B cell subset responding to T-independent type 2 antigens such as bacterial capsular polysaccharides. They are clinically relevant by providing rapid protection against bacterial diseases such pneumococcal pneumonia. In this chapter we review features of their location, development and function and compare cross species differences and similarities. (Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Reference Module in Life Sciences
editor
Giordano, Antonio ; Ranganathan, Shoba ; Cotter, Paul D. and Vitale, Ilio
edition
1
pages
11 pages
publisher
Elsevier
ISBN
9780128096338
DOI
10.1016/B978-0-128-24465-4.00063-6
language
English
LU publication?
yes
id
22ca5118-5766-412c-8eaf-d56a047b44b4
date added to LUP
2024-10-28 11:05:57
date last changed
2025-04-04 14:55:30
@inbook{22ca5118-5766-412c-8eaf-d56a047b44b4,
  abstract     = {{Marginal zone B cells (MZB cells) are innate like B cells that are predominantly located alongside memory B cells in the microanatomical region of the spleen of humans and mice termed the marginal zone. They circulate in humans but not mice, and in humans can be identified in blood and other lymphoid tissues, including the gut-associated lymphoid tissue, where they, as in spleen, form a zone surrounding the naïve B cells. Although MZB cells in mice and humans differ in their derivation and fine microanatomic and systemic distribution, they converge in function as the major B cell subset responding to T-independent type 2 antigens such as bacterial capsular polysaccharides. They are clinically relevant by providing rapid protection against bacterial diseases such pneumococcal pneumonia. In this chapter we review features of their location, development and function and compare cross species differences and similarities.}},
  author       = {{Spencer, Jo and Bemark, Mats}},
  booktitle    = {{Reference Module in Life Sciences}},
  editor       = {{Giordano, Antonio and Ranganathan, Shoba and Cotter, Paul D. and Vitale, Ilio}},
  isbn         = {{9780128096338}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  title        = {{MZB Cell Development and Function}},
  url          = {{http://dx.doi.org/10.1016/B978-0-128-24465-4.00063-6}},
  doi          = {{10.1016/B978-0-128-24465-4.00063-6}},
  year         = {{2024}},
}