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Heat production rate in blood lymphocytes as a prognostic factor in non‐Hodgkin's lymphoma

Monti, M.; Brandt, L.; Ikomi‐Kumm, J. and Olsson, H. LU (1990) In European Journal of Haematology 45(5). p.250-254
Abstract

Abstract: The heat production rate in peripheral blood lymphocytes was evaluated by direct calorimetry in 76 untreated adults with non‐Hodgkin's lymphoma (NHL). Elevated values were recorded for 20 out of 54 patients with lymphomas of high or intermediate malignancy grade (37%) and for 1 out of 22 patients (5%) with low grade lymphomas (p = 0.01). Median survival was 39 months for patients with normal values and 8.5 months for those with elevated values (p = 0.005). In a subgroup of 38 patients with high or intermediate grade NHL stage III‐IV, 17 patients with abnormally high lymphocyte heat production rates had a significantly shorter survival than 21 patients with normal values (p = 0.01). In a multivariate analysis the prognostic... (More)

Abstract: The heat production rate in peripheral blood lymphocytes was evaluated by direct calorimetry in 76 untreated adults with non‐Hodgkin's lymphoma (NHL). Elevated values were recorded for 20 out of 54 patients with lymphomas of high or intermediate malignancy grade (37%) and for 1 out of 22 patients (5%) with low grade lymphomas (p = 0.01). Median survival was 39 months for patients with normal values and 8.5 months for those with elevated values (p = 0.005). In a subgroup of 38 patients with high or intermediate grade NHL stage III‐IV, 17 patients with abnormally high lymphocyte heat production rates had a significantly shorter survival than 21 patients with normal values (p = 0.01). In a multivariate analysis the prognostic impact of lymphocyte heat production was superior to histologic malignancy grade, clinical stage and age.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood lymphocytes, calori‐metry, non‐Hodgkin lymphoma, prognosis
in
European Journal of Haematology
volume
45
issue
5
pages
250 - 254
publisher
Wiley-Blackwell
external identifiers
  • scopus:0025667803
ISSN
0902-4441
DOI
10.1111/j.1600-0609.1990.tb00469.x
language
English
LU publication?
yes
id
22d197b1-1070-42c6-af52-ccf696386bb6
date added to LUP
2018-12-19 13:22:33
date last changed
2019-01-06 14:20:45
@article{22d197b1-1070-42c6-af52-ccf696386bb6,
  abstract     = {<p>Abstract:  The heat production rate in peripheral blood lymphocytes was evaluated by direct calorimetry in 76 untreated adults with non‐Hodgkin's lymphoma (NHL). Elevated values were recorded for 20 out of 54 patients with lymphomas of high or intermediate malignancy grade (37%) and for 1 out of 22 patients (5%) with low grade lymphomas (p = 0.01). Median survival was 39 months for patients with normal values and 8.5 months for those with elevated values (p = 0.005). In a subgroup of 38 patients with high or intermediate grade NHL stage III‐IV, 17 patients with abnormally high lymphocyte heat production rates had a significantly shorter survival than 21 patients with normal values (p = 0.01). In a multivariate analysis the prognostic impact of lymphocyte heat production was superior to histologic malignancy grade, clinical stage and age.</p>},
  author       = {Monti, M. and Brandt, L. and Ikomi‐Kumm, J. and Olsson, H.},
  issn         = {0902-4441},
  keyword      = {blood lymphocytes,calori‐metry,non‐Hodgkin lymphoma,prognosis},
  language     = {eng},
  month        = {01},
  number       = {5},
  pages        = {250--254},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {Heat production rate in blood lymphocytes as a prognostic factor in non‐Hodgkin's lymphoma},
  url          = {http://dx.doi.org/10.1111/j.1600-0609.1990.tb00469.x},
  volume       = {45},
  year         = {1990},
}