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ESR Essentials : Perfusion MRI—practice recommendations by the European Society for Magnetic Resonance in Medicine and Biology

van Houdt, Petra J. ; Václavů, Lena ; Sourbron, Steven ; Shalom, Eve S. ; Federau, Christian ; Iima, Mami ; Liu, Mira M. ; Knutsson, Linda LU orcid ; Wirestam, Ronnie LU orcid and Günther, Matthias , et al. (2026) In European Radiology
Abstract

Abstract: Perfusion MRI techniques—including dynamic susceptibility contrast (DSC) MRI, dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and intravoxel incoherent motion (IVIM) MRI—hold strong potential as imaging techniques for diagnosing, staging, and monitoring disease across a range of clinical applications. However, clinical adoption, especially of quantitative parameters, remains variable across techniques. Key barriers to broader implementation include a lack of standardized acquisition and analysis protocols, leading to poor reproducibility and reduced clinical confidence. Additionally, limited awareness and understanding of certain techniques among radiologists contribute to underutilization in practice.... (More)

Abstract: Perfusion MRI techniques—including dynamic susceptibility contrast (DSC) MRI, dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and intravoxel incoherent motion (IVIM) MRI—hold strong potential as imaging techniques for diagnosing, staging, and monitoring disease across a range of clinical applications. However, clinical adoption, especially of quantitative parameters, remains variable across techniques. Key barriers to broader implementation include a lack of standardized acquisition and analysis protocols, leading to poor reproducibility and reduced clinical confidence. Additionally, limited awareness and understanding of certain techniques among radiologists contribute to underutilization in practice. This work provides practice recommendations to support radiologists in integrating perfusion MRI into routine clinical workflows. It includes guidance on technique selection, acquisition, and analysis, supported by a flowchart outlining typical imaging pathways. These efforts align with ongoing initiatives such as the Quantitative Medical Imaging Coalition (formerly QIBA) and the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI), which are developing standards and tools to enhance reproducibility and clinical utility. Ultimately, the successful adoption of state-of-the-art perfusion MRI depends on close collaboration between clinicians, researchers, and industry stakeholders to ensure robust, standardized, and clinically meaningful application. Key Points: Perfusion MRI parameters hold great promise as imaging biomarkers, but their clinical adoption, especially of quantitative parameters, remains variable across perfusion MRI techniques. An overview of perfusion MRI techniques, explaining the physics, illustrating clinical applications, and addressing common technical challenges, is provided to support perfusion MRI use in clinical practice. Successful adoption of state-of-the-art perfusion MRI depends on close collaboration between clinicians, researchers, and industry stakeholders to ensure robust, standardized, and clinically meaningful applications for patient care.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Contrast media, Perfusion magnetic resonance imaging, Radiologists
in
European Radiology
publisher
Springer Science and Business Media B.V.
external identifiers
  • pmid:41591472
  • scopus:105029164723
ISSN
0938-7994
DOI
10.1007/s00330-025-12306-5
language
English
LU publication?
yes
id
22f8d36c-2b68-42bf-8e92-13eb365b1966
date added to LUP
2026-02-20 14:53:06
date last changed
2026-02-20 14:54:18
@article{22f8d36c-2b68-42bf-8e92-13eb365b1966,
  abstract     = {{<p>Abstract: Perfusion MRI techniques—including dynamic susceptibility contrast (DSC) MRI, dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and intravoxel incoherent motion (IVIM) MRI—hold strong potential as imaging techniques for diagnosing, staging, and monitoring disease across a range of clinical applications. However, clinical adoption, especially of quantitative parameters, remains variable across techniques. Key barriers to broader implementation include a lack of standardized acquisition and analysis protocols, leading to poor reproducibility and reduced clinical confidence. Additionally, limited awareness and understanding of certain techniques among radiologists contribute to underutilization in practice. This work provides practice recommendations to support radiologists in integrating perfusion MRI into routine clinical workflows. It includes guidance on technique selection, acquisition, and analysis, supported by a flowchart outlining typical imaging pathways. These efforts align with ongoing initiatives such as the Quantitative Medical Imaging Coalition (formerly QIBA) and the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI), which are developing standards and tools to enhance reproducibility and clinical utility. Ultimately, the successful adoption of state-of-the-art perfusion MRI depends on close collaboration between clinicians, researchers, and industry stakeholders to ensure robust, standardized, and clinically meaningful application. Key Points: Perfusion MRI parameters hold great promise as imaging biomarkers, but their clinical adoption, especially of quantitative parameters, remains variable across perfusion MRI techniques. An overview of perfusion MRI techniques, explaining the physics, illustrating clinical applications, and addressing common technical challenges, is provided to support perfusion MRI use in clinical practice. Successful adoption of state-of-the-art perfusion MRI depends on close collaboration between clinicians, researchers, and industry stakeholders to ensure robust, standardized, and clinically meaningful applications for patient care.</p>}},
  author       = {{van Houdt, Petra J. and Václavů, Lena and Sourbron, Steven and Shalom, Eve S. and Federau, Christian and Iima, Mami and Liu, Mira M. and Knutsson, Linda and Wirestam, Ronnie and Günther, Matthias and van Osch, Matthias J.P. and van der Heijden, Rianne A.}},
  issn         = {{0938-7994}},
  keywords     = {{Contrast media; Perfusion magnetic resonance imaging; Radiologists}},
  language     = {{eng}},
  publisher    = {{Springer Science and Business Media B.V.}},
  series       = {{European Radiology}},
  title        = {{ESR Essentials : Perfusion MRI—practice recommendations by the European Society for Magnetic Resonance in Medicine and Biology}},
  url          = {{http://dx.doi.org/10.1007/s00330-025-12306-5}},
  doi          = {{10.1007/s00330-025-12306-5}},
  year         = {{2026}},
}