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Anti-inflammatory effect of oligostilbenoids from Vitis heyneana in LPS-stimulated RAW 264.7 macrophages via suppressing the NF-ΚB activation

Ha, Do Thi; Long, Phung Thanh; Hien, Tran Thi LU ; Tuan, Dao Trong; An, Nguyen Thi Thuy; Khoi, Nguyen Minh; Oanh, Ha and Hung, Tran Manh (2018) In Chemistry Central Journal 12(1).
Abstract

Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10).... (More)

Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10). Compound 5 showed the most potent inhibitory activities by suppressing LPS-induced COX-2 expression and PGE2 production. This compound exhibited significantly reduced LPS-induced nitric oxide (NO) release in a dose-dependent manner. These effects are accompanied with the inhibition of transcription factor NF-ΚB activation. Conclusion: The results suggested that trans-ε-viniferin exerts anti-inflammatory effects via suppression the NF-ΚB activation in RAW 264.7 cells. [Figure not available: see fulltext.]

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
(-)-Trans-ε-viniferin, COX-2, NF-ΚB, NO, PGE2, Vitis heyneana
in
Chemistry Central Journal
volume
12
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85042128726
ISSN
1752-153X
DOI
10.1186/s13065-018-0386-5
language
English
LU publication?
yes
id
231219a3-3959-483a-b9cf-636e662b57ab
date added to LUP
2018-03-07 06:55:09
date last changed
2018-05-29 10:36:56
@article{231219a3-3959-483a-b9cf-636e662b57ab,
  abstract     = {<p>Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10). Compound 5 showed the most potent inhibitory activities by suppressing LPS-induced COX-2 expression and PGE2 production. This compound exhibited significantly reduced LPS-induced nitric oxide (NO) release in a dose-dependent manner. These effects are accompanied with the inhibition of transcription factor NF-ΚB activation. Conclusion: The results suggested that trans-ε-viniferin exerts anti-inflammatory effects via suppression the NF-ΚB activation in RAW 264.7 cells. [Figure not available: see fulltext.]</p>},
  articleno    = {14},
  author       = {Ha, Do Thi and Long, Phung Thanh and Hien, Tran Thi and Tuan, Dao Trong and An, Nguyen Thi Thuy and Khoi, Nguyen Minh and Oanh, Ha and Hung, Tran Manh},
  issn         = {1752-153X},
  keyword      = {(-)-Trans-ε-viniferin,COX-2,NF-ΚB,NO,PGE2,Vitis heyneana},
  language     = {eng},
  month        = {02},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Chemistry Central Journal},
  title        = {Anti-inflammatory effect of oligostilbenoids from Vitis heyneana in LPS-stimulated RAW 264.7 macrophages via suppressing the NF-ΚB activation},
  url          = {http://dx.doi.org/10.1186/s13065-018-0386-5},
  volume       = {12},
  year         = {2018},
}