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Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis

Berglund, M; Thunberg, U; Amini, RM; Book, M; Roos, G; Erlanson, M; Linderoth, Johan LU ; Dictor, Michael LU ; Jerkeman, Mats LU and Cavallin-Ståhl, Eva LU , et al. (2005) In Modern Pathology 18(8). p.1113-1120
Abstract
Diffuse large B-cell lymphoma (DLBCL) has been shown to be comprised of at least two prognostic entities, depending on its resemblance to normal germinal center or activated B cells, using global gene expression profiling. Also, the expression patterns of bcl-6, CD10 and IRF-4 ( also known as MUM1) have been suggested as alternative means of identifying the germinal- and nongerminal center ( activated B-cell like) groups. In the present study, we evaluated by immunohistochemistry the expression patterns of CD10, bcl-6, IRF-4 and bcl-2 in a large material of 161 DLBCL patients. Using two different approaches, patients with germinal center phenotype displayed a significantly better survival than the nongerminal center group. Positive... (More)
Diffuse large B-cell lymphoma (DLBCL) has been shown to be comprised of at least two prognostic entities, depending on its resemblance to normal germinal center or activated B cells, using global gene expression profiling. Also, the expression patterns of bcl-6, CD10 and IRF-4 ( also known as MUM1) have been suggested as alternative means of identifying the germinal- and nongerminal center ( activated B-cell like) groups. In the present study, we evaluated by immunohistochemistry the expression patterns of CD10, bcl-6, IRF-4 and bcl-2 in a large material of 161 DLBCL patients. Using two different approaches, patients with germinal center phenotype displayed a significantly better survival than the nongerminal center group. Positive staining for bcl-6 or CD10 predicted for superior survival, while expression of IRF-4 alone showed no association with prognosis. Furthermore, expression of bcl-2 was associated with worse event-free survival and overall survival. In a multivariate analysis, a high international prognostic index score ( 3 - 5), non-GC phenotype and bcl-2 were independent adverse prognostic factors. Here we confirm the prognostic importance of determining the germinal- or nongerminal center phenotype in patients with DLBCL. (Less)
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published
subject
keywords
lymphoma, germinal center, prognosis
in
Modern Pathology
volume
18
issue
8
pages
1113 - 1120
publisher
Nature Publishing Group
external identifiers
  • wos:000230646000014
  • pmid:15920553
  • scopus:24044473086
ISSN
1530-0285
DOI
10.1038/modpathol.3800396
language
English
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yes
id
21a73151-f955-4d63-bc76-913cf55f0156 (old id 232280)
date added to LUP
2007-08-10 10:47:33
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2017-10-22 04:38:47
@article{21a73151-f955-4d63-bc76-913cf55f0156,
  abstract     = {Diffuse large B-cell lymphoma (DLBCL) has been shown to be comprised of at least two prognostic entities, depending on its resemblance to normal germinal center or activated B cells, using global gene expression profiling. Also, the expression patterns of bcl-6, CD10 and IRF-4 ( also known as MUM1) have been suggested as alternative means of identifying the germinal- and nongerminal center ( activated B-cell like) groups. In the present study, we evaluated by immunohistochemistry the expression patterns of CD10, bcl-6, IRF-4 and bcl-2 in a large material of 161 DLBCL patients. Using two different approaches, patients with germinal center phenotype displayed a significantly better survival than the nongerminal center group. Positive staining for bcl-6 or CD10 predicted for superior survival, while expression of IRF-4 alone showed no association with prognosis. Furthermore, expression of bcl-2 was associated with worse event-free survival and overall survival. In a multivariate analysis, a high international prognostic index score ( 3 - 5), non-GC phenotype and bcl-2 were independent adverse prognostic factors. Here we confirm the prognostic importance of determining the germinal- or nongerminal center phenotype in patients with DLBCL.},
  author       = {Berglund, M and Thunberg, U and Amini, RM and Book, M and Roos, G and Erlanson, M and Linderoth, Johan and Dictor, Michael and Jerkeman, Mats and Cavallin-Ståhl, Eva and Sundstrom, C and Rehn-Eriksson, S and Backlin, C and Hagberg, H and Rosenquist, R and Enblad, G},
  issn         = {1530-0285},
  keyword      = {lymphoma,germinal center,prognosis},
  language     = {eng},
  number       = {8},
  pages        = {1113--1120},
  publisher    = {Nature Publishing Group},
  series       = {Modern Pathology},
  title        = {Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis},
  url          = {http://dx.doi.org/10.1038/modpathol.3800396},
  volume       = {18},
  year         = {2005},
}