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The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent

Jacobs, Heidi I. L.; Visser, Pieter Jelle; Van Boxtel, Martin P. J.; Frisoni, Giovanni B.; Tsolaki, Magda; Papapostolou, Panagiota; Nobili, Flavio; Wahlund, Lars-Olof; Minthon, Lennart LU and Frolich, Lutz, et al. (2012) In Neurobiology of Aging 33(1). p.1-201
Abstract
White matter hyperintensities (WMH) in Mild Cognitive Impairment (MCI) have been associated with impaired executive functioning, although contradictory findings have been reported. The aim of this study was to examine whether WMH location influenced the relation between WMH and executive functioning in MCI participants (55-90 years) in the European multicenter memory-clinic-based DESCRIPA study, who underwent MRI scanning at baseline (N = 337). Linear mixed model analysis was performed to test the association between WMH damage in three networks (frontal-parietal, frontal-subcortical and frontal-parietal-subcortical network) and change in executive functioning over a 3-year period. WMH in the frontal-parietal and in the... (More)
White matter hyperintensities (WMH) in Mild Cognitive Impairment (MCI) have been associated with impaired executive functioning, although contradictory findings have been reported. The aim of this study was to examine whether WMH location influenced the relation between WMH and executive functioning in MCI participants (55-90 years) in the European multicenter memory-clinic-based DESCRIPA study, who underwent MRI scanning at baseline (N = 337). Linear mixed model analysis was performed to test the association between WMH damage in three networks (frontal-parietal, frontal-subcortical and frontal-parietal-subcortical network) and change in executive functioning over a 3-year period. WMH in the frontal-parietal and in the frontal-parietal-subcortical network were associated with decline in executive functioning. However, the frontal-subcortical network was not associated with change in executive functioning. Our results suggest that parietal WMH are a significant contributor to executive decline in MCI and that investigation of WMH in the cerebral networks supporting cognitive functions provide a new way to differentiate stable from cognitive declining MCI individuals. (C) 2012 Elsevier Inc. All rights reserved. (Less)
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keywords
Mild cognitive impairment, White matter hyperintensities, Executive, function, Frontoparietal circuit
in
Neurobiology of Aging
volume
33
issue
1
pages
1 - 201
publisher
Elsevier
external identifiers
  • wos:000297934700036
  • scopus:81355141976
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2010.07.015
language
English
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yes
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30e86c3a-8263-42cf-b461-21ee299aa758 (old id 2333875)
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2012-02-01 07:41:02
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@article{30e86c3a-8263-42cf-b461-21ee299aa758,
  abstract     = {White matter hyperintensities (WMH) in Mild Cognitive Impairment (MCI) have been associated with impaired executive functioning, although contradictory findings have been reported. The aim of this study was to examine whether WMH location influenced the relation between WMH and executive functioning in MCI participants (55-90 years) in the European multicenter memory-clinic-based DESCRIPA study, who underwent MRI scanning at baseline (N = 337). Linear mixed model analysis was performed to test the association between WMH damage in three networks (frontal-parietal, frontal-subcortical and frontal-parietal-subcortical network) and change in executive functioning over a 3-year period. WMH in the frontal-parietal and in the frontal-parietal-subcortical network were associated with decline in executive functioning. However, the frontal-subcortical network was not associated with change in executive functioning. Our results suggest that parietal WMH are a significant contributor to executive decline in MCI and that investigation of WMH in the cerebral networks supporting cognitive functions provide a new way to differentiate stable from cognitive declining MCI individuals. (C) 2012 Elsevier Inc. All rights reserved.},
  author       = {Jacobs, Heidi I. L. and Visser, Pieter Jelle and Van Boxtel, Martin P. J. and Frisoni, Giovanni B. and Tsolaki, Magda and Papapostolou, Panagiota and Nobili, Flavio and Wahlund, Lars-Olof and Minthon, Lennart and Frolich, Lutz and Hampel, Harald and Soininen, Hilkka and van de Pol, Laura and Scheltens, Philip and Tan, Frans E. S. and Jolles, Jelle and Verhey, Frans R. J.},
  issn         = {1558-1497},
  keyword      = {Mild cognitive impairment,White matter hyperintensities,Executive,function,Frontoparietal circuit},
  language     = {eng},
  number       = {1},
  pages        = {1--201},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2010.07.015},
  volume       = {33},
  year         = {2012},
}