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Association of irritable bowel syndrome and venous thromboembolism

Zöller, Bengt LU ; Ohlsson, Henrik LU ; Waehrens, Rasmus LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2018) In Scandinavian Journal of Gastroenterology
Abstract

OBJECTIVE: Inflammatory bowel disease (IBD) is associated with venous thromboembolism (VTE). Whether functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), are associated with VTE has not been determined. This nationwide study aimed to determine the risk of VTE in IBS outpatients in primary and specialist care.

DESIGN: We performed two matched case-control studies. Cases (n = 90,502) were individuals in Sweden aged 18-80 years with a first hospital diagnosis of VTE between 2001 and 2010. Five controls (n = 452,510) from the Swedish Total Population Register were matched to each case for birth, sex, country of birth, and education level. Diagnosis of IBS was determined in the Swedish hospital outpatient... (More)

OBJECTIVE: Inflammatory bowel disease (IBD) is associated with venous thromboembolism (VTE). Whether functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), are associated with VTE has not been determined. This nationwide study aimed to determine the risk of VTE in IBS outpatients in primary and specialist care.

DESIGN: We performed two matched case-control studies. Cases (n = 90,502) were individuals in Sweden aged 18-80 years with a first hospital diagnosis of VTE between 2001 and 2010. Five controls (n = 452,510) from the Swedish Total Population Register were matched to each case for birth, sex, country of birth, and education level. Diagnosis of IBS was determined in the Swedish hospital outpatient register. This procedure was replicated for the primary care population. As the Primary Care data did not have nationwide coverage, we only included individuals that were registered in the Primary Care database. A total of 9766 cases of hospital diagnosed VTE individuals could be found in the Primary Care population and they were matched to 48,830 controls also from the Primary health care population. Conditional logistic regression was used to determine odds ratio (OR) for first VTE diagnosis. Results The adjusted OR for VTE when IBS was diagnosed in hospital outpatient care was 1.49 (95% confidence interval 1.33-1.67). The crude OR for VTE was 1.18 (0.94-1.48) when IBS was diagnosed in primary care.

CONCLUSIONS: This is the first study describing an association between VTE and IBS. The results suggest that specialist treated IBS patients have increased risk of VTE.

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author
organization
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publication status
epub
subject
keywords
Journal Article
in
Scandinavian Journal of Gastroenterology
pages
6 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85046013211
ISSN
1502-7708
DOI
10.1080/00365521.2018.1465118
language
English
LU publication?
yes
id
2334ed84-23c0-4156-8bac-be8a40814ebe
date added to LUP
2018-04-28 00:53:49
date last changed
2018-05-20 04:42:01
@article{2334ed84-23c0-4156-8bac-be8a40814ebe,
  abstract     = {<p>OBJECTIVE: Inflammatory bowel disease (IBD) is associated with venous thromboembolism (VTE). Whether functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), are associated with VTE has not been determined. This nationwide study aimed to determine the risk of VTE in IBS outpatients in primary and specialist care.</p><p>DESIGN: We performed two matched case-control studies. Cases (n = 90,502) were individuals in Sweden aged 18-80 years with a first hospital diagnosis of VTE between 2001 and 2010. Five controls (n = 452,510) from the Swedish Total Population Register were matched to each case for birth, sex, country of birth, and education level. Diagnosis of IBS was determined in the Swedish hospital outpatient register. This procedure was replicated for the primary care population. As the Primary Care data did not have nationwide coverage, we only included individuals that were registered in the Primary Care database. A total of 9766 cases of hospital diagnosed VTE individuals could be found in the Primary Care population and they were matched to 48,830 controls also from the Primary health care population. Conditional logistic regression was used to determine odds ratio (OR) for first VTE diagnosis. Results The adjusted OR for VTE when IBS was diagnosed in hospital outpatient care was 1.49 (95% confidence interval 1.33-1.67). The crude OR for VTE was 1.18 (0.94-1.48) when IBS was diagnosed in primary care.</p><p>CONCLUSIONS: This is the first study describing an association between VTE and IBS. The results suggest that specialist treated IBS patients have increased risk of VTE.</p>},
  author       = {Zöller, Bengt and Ohlsson, Henrik and Waehrens, Rasmus and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1502-7708},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {04},
  pages        = {6},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Association of irritable bowel syndrome and venous thromboembolism},
  url          = {http://dx.doi.org/10.1080/00365521.2018.1465118},
  year         = {2018},
}