A case-controlled evaluation of the Medtronic Resting Heart System compared with conventional cardiopulmonary bypass in patients undergoing isolated coronary artery bypass surgery.
Nozohoor, Shahab LU ; Johnsson, Per ; Scicluna, Sara LU ; Wallentin, Per ; Andell, Elisabeth and Nilsson, Johan LU
(2012)
In Interactive Cardiovascular and Thoracic Surgery
14(5).
p.599-604
- Abstract
- The Medtronic Resting Heart System (RHS) is a heparin-coated, closed perfusion circuit. Clinical results indicate less haemodilution and reduced complement activation, when compared with a traditional circuit leading to fewer postoperative blood transfusions. We evaluated the potential clinical benefits, including reduced transfusion requirements, when using the RHS compared with conventional cardiopulmonary bypass (cCPB). The study group (n = 330) consisted of patients undergoing isolated coronary artery bypass grafting (CABG) using the RHS system during 2005-2009, matched with a control group (n = 609) including patients operated for isolated CABG during 2002-2009, utilizing cCPB. Significantly fewer patients received peri- and... (More)
- The Medtronic Resting Heart System (RHS) is a heparin-coated, closed perfusion circuit. Clinical results indicate less haemodilution and reduced complement activation, when compared with a traditional circuit leading to fewer postoperative blood transfusions. We evaluated the potential clinical benefits, including reduced transfusion requirements, when using the RHS compared with conventional cardiopulmonary bypass (cCPB). The study group (n = 330) consisted of patients undergoing isolated coronary artery bypass grafting (CABG) using the RHS system during 2005-2009, matched with a control group (n = 609) including patients operated for isolated CABG during 2002-2009, utilizing cCPB. Significantly fewer patients received peri- and postoperative blood transfusions in the RHS group (25 vs. 37%, P < 0.001; mean 1.0 ± 2.6 vs. mean 1.6 ± 2.9 units of packed red blood cells). The incidence of reoperations due to bleeding was low, RHS 2% (n = 8) vs. cCPB 5% (n = 29), with a trend towards no significant difference between groups (P = 0.079). The duration of mechanical ventilation was shorter (mean 7 ± 16 vs. 9 ± 12 h, P < 0.001) for patients in the RHS group. This study demonstrates that CABG performed with the RHS reduces the incidence and magnitude of allogenic blood transfusion and results in a satisfactory clinical outcome. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2335929
- author
- Nozohoor, Shahab
LU
; Johnsson, Per
; Scicluna, Sara
LU
; Wallentin, Per
; Andell, Elisabeth
and Nilsson, Johan
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Interactive Cardiovascular and Thoracic Surgery
- volume
- 14
- issue
- 5
- pages
- 599 - 604
- publisher
- European Association of Cardio-Thoracic Surgery
- external identifiers
-
- wos:000310174900022
- pmid:22286599
- scopus:84863434778
- ISSN
- 1569-9285
- DOI
- 10.1093/icvts/ivr158
- language
- English
- LU publication?
- yes
- id
- a323db96-35ed-47b8-8de8-69475766e764 (old id 2335929)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22286599?dopt=Abstract
- date added to LUP
- 2016-04-04 07:07:45
- date last changed
- 2022-01-29 01:44:13
@article{a323db96-35ed-47b8-8de8-69475766e764,
abstract = {{The Medtronic Resting Heart System (RHS) is a heparin-coated, closed perfusion circuit. Clinical results indicate less haemodilution and reduced complement activation, when compared with a traditional circuit leading to fewer postoperative blood transfusions. We evaluated the potential clinical benefits, including reduced transfusion requirements, when using the RHS compared with conventional cardiopulmonary bypass (cCPB). The study group (n = 330) consisted of patients undergoing isolated coronary artery bypass grafting (CABG) using the RHS system during 2005-2009, matched with a control group (n = 609) including patients operated for isolated CABG during 2002-2009, utilizing cCPB. Significantly fewer patients received peri- and postoperative blood transfusions in the RHS group (25 vs. 37%, P < 0.001; mean 1.0 ± 2.6 vs. mean 1.6 ± 2.9 units of packed red blood cells). The incidence of reoperations due to bleeding was low, RHS 2% (n = 8) vs. cCPB 5% (n = 29), with a trend towards no significant difference between groups (P = 0.079). The duration of mechanical ventilation was shorter (mean 7 ± 16 vs. 9 ± 12 h, P < 0.001) for patients in the RHS group. This study demonstrates that CABG performed with the RHS reduces the incidence and magnitude of allogenic blood transfusion and results in a satisfactory clinical outcome.}},
author = {{Nozohoor, Shahab and Johnsson, Per and Scicluna, Sara and Wallentin, Per and Andell, Elisabeth and Nilsson, Johan}},
issn = {{1569-9285}},
language = {{eng}},
number = {{5}},
pages = {{599--604}},
publisher = {{European Association of Cardio-Thoracic Surgery}},
series = {{Interactive Cardiovascular and Thoracic Surgery}},
title = {{A case-controlled evaluation of the Medtronic Resting Heart System compared with conventional cardiopulmonary bypass in patients undergoing isolated coronary artery bypass surgery.}},
url = {{http://dx.doi.org/10.1093/icvts/ivr158}},
doi = {{10.1093/icvts/ivr158}},
volume = {{14}},
year = {{2012}},
}