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Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease.

Björkqvist, Maria LU ; Ohlsson, Mattias LU ; Minthon, Lennart LU and Hansson, Oskar LU (2012) In PLoS ONE 7(1).
Abstract
There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative... (More)
There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
7
issue
1
publisher
Public Library of Science
external identifiers
  • wos:000299771900029
  • pmid:22279551
  • scopus:84855975889
ISSN
1932-6203
DOI
10.1371/journal.pone.0029868
language
English
LU publication?
yes
id
7750e1b4-c2bf-4324-bb51-d967639dc4d9 (old id 2335988)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22279551?dopt=Abstract
date added to LUP
2012-02-01 23:02:13
date last changed
2017-11-05 04:05:47
@article{7750e1b4-c2bf-4324-bb51-d967639dc4d9,
  abstract     = {There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies.},
  articleno    = {e29868},
  author       = {Björkqvist, Maria and Ohlsson, Mattias and Minthon, Lennart and Hansson, Oskar},
  issn         = {1932-6203},
  language     = {eng},
  number       = {1},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0029868},
  volume       = {7},
  year         = {2012},
}