Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease.
Björkqvist, Maria LU
; Ohlsson, Mattias
LU
; Minthon, Lennart
LU
and Hansson, Oskar
LU
(2012)
In PLoS ONE
7(1).
- Abstract
- There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative... (More)
- There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2335988
- author
- Björkqvist, Maria
LU
; Ohlsson, Mattias
LU
; Minthon, Lennart
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 7
- issue
- 1
- article number
- e29868
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000299771900029
- pmid:22279551
- scopus:84855975889
- pmid:22279551
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0029868
- language
- English
- LU publication?
- yes
- id
- 7750e1b4-c2bf-4324-bb51-d967639dc4d9 (old id 2335988)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22279551?dopt=Abstract
- date added to LUP
- 2016-04-01 14:05:02
- date last changed
- 2024-04-10 15:13:26
@article{7750e1b4-c2bf-4324-bb51-d967639dc4d9,
abstract = {{There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies.}},
author = {{Björkqvist, Maria and Ohlsson, Mattias and Minthon, Lennart and Hansson, Oskar}},
issn = {{1932-6203}},
language = {{eng}},
number = {{1}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease.}},
url = {{https://lup.lub.lu.se/search/files/3767864/2369392.pdf}},
doi = {{10.1371/journal.pone.0029868}},
volume = {{7}},
year = {{2012}},
}