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Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis.

Silva, Tania LU ; Oredsson, Stina LU ; Persson, Lo LU ; Woster, P and Marques, M P M (2012) In Journal of Inorganic Biochemistry 108(March). p.1-7
Abstract
A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very... (More)
A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Modified polyamines, Pt(II) / Pd(II) complexes, Raman spectroscopy, Infrared spectroscopy, Anticancer
in
Journal of Inorganic Biochemistry
volume
108
issue
March
pages
1 - 7
publisher
Elsevier
external identifiers
  • wos:000302205600001
  • pmid:22265832
  • scopus:84855870600
ISSN
1873-3344
DOI
10.1016/j.jinorgbio.2011.11.021
language
English
LU publication?
yes
id
c66abebf-2cad-4c70-ad8c-4fa5098bae7c (old id 2336135)
date added to LUP
2012-02-10 12:44:18
date last changed
2017-01-01 03:26:36
@article{c66abebf-2cad-4c70-ad8c-4fa5098bae7c,
  abstract     = {A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties.},
  author       = {Silva, Tania and Oredsson, Stina and Persson, Lo and Woster, P and Marques, M P M},
  issn         = {1873-3344},
  keyword      = {Modified polyamines,Pt(II) / Pd(II) complexes,Raman spectroscopy,Infrared spectroscopy,Anticancer},
  language     = {eng},
  number       = {March},
  pages        = {1--7},
  publisher    = {Elsevier},
  series       = {Journal of Inorganic Biochemistry},
  title        = {Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis.},
  url          = {http://dx.doi.org/10.1016/j.jinorgbio.2011.11.021},
  volume       = {108},
  year         = {2012},
}