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Glutamate dehydrogenase, insulin secretion and Type 2 Diabetes. A new means to protect the pancreatic β-cell?

Göhring, Isabel LU and Mulder, Hindrik LU (2012) In Journal of Endocrinology 212(3). p.239-242
Abstract
In this issue of Journal of Endocrinology, Dr Han and colleagues report a protective effect of the glutamate dehydrogenase-activator BCH under diabetes-like conditions that impair β-cell function in both a pancreatic β-cell line and in db/db mice. Based on these observations, the authors suggest that BCH could serve as novel treatment modality in Type 2 Diabetes. The present commentary discusses the importance of the findings. Some additional questions are raised, that may be addressed in future investigations, as is some concern regarding BCH treatment of β-cell failure.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Endocrinology
volume
212
issue
3
pages
239 - 242
publisher
Society for Endocrinology
external identifiers
  • wos:000302116400001
  • pmid:22232141
  • scopus:84857839613
ISSN
1479-6805
DOI
10.1530/JOE-11-0481
language
English
LU publication?
yes
id
bd81debf-5c1b-4810-bb03-9ea0e0577051 (old id 2336591)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22232141?dopt=Abstract
date added to LUP
2012-02-01 20:08:17
date last changed
2017-01-01 03:58:26
@article{bd81debf-5c1b-4810-bb03-9ea0e0577051,
  abstract     = {In this issue of Journal of Endocrinology, Dr Han and colleagues report a protective effect of the glutamate dehydrogenase-activator BCH under diabetes-like conditions that impair β-cell function in both a pancreatic β-cell line and in db/db mice. Based on these observations, the authors suggest that BCH could serve as novel treatment modality in Type 2 Diabetes. The present commentary discusses the importance of the findings. Some additional questions are raised, that may be addressed in future investigations, as is some concern regarding BCH treatment of β-cell failure.},
  author       = {Göhring, Isabel and Mulder, Hindrik},
  issn         = {1479-6805},
  language     = {eng},
  number       = {3},
  pages        = {239--242},
  publisher    = {Society for Endocrinology},
  series       = {Journal of Endocrinology},
  title        = {Glutamate dehydrogenase, insulin secretion and Type 2 Diabetes. A new means to protect the pancreatic β-cell?},
  url          = {http://dx.doi.org/10.1530/JOE-11-0481},
  volume       = {212},
  year         = {2012},
}