Glutamate dehydrogenase, insulin secretion and Type 2 Diabetes. A new means to protect the pancreatic β-cell?
(2012) In Journal of Endocrinology 212(3). p.239-242- Abstract
- In this issue of Journal of Endocrinology, Dr Han and colleagues report a protective effect of the glutamate dehydrogenase-activator BCH under diabetes-like conditions that impair β-cell function in both a pancreatic β-cell line and in db/db mice. Based on these observations, the authors suggest that BCH could serve as novel treatment modality in Type 2 Diabetes. The present commentary discusses the importance of the findings. Some additional questions are raised, that may be addressed in future investigations, as is some concern regarding BCH treatment of β-cell failure.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2336591
- author
- Göhring, Isabel LU and Mulder, Hindrik LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Endocrinology
- volume
- 212
- issue
- 3
- pages
- 239 - 242
- publisher
- Society for Endocrinology
- external identifiers
-
- wos:000302116400001
- pmid:22232141
- scopus:84857839613
- pmid:22232141
- ISSN
- 1479-6805
- DOI
- 10.1530/JOE-11-0481
- language
- English
- LU publication?
- yes
- id
- bd81debf-5c1b-4810-bb03-9ea0e0577051 (old id 2336591)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22232141?dopt=Abstract
- date added to LUP
- 2016-04-01 10:52:34
- date last changed
- 2022-02-02 21:51:10
@article{bd81debf-5c1b-4810-bb03-9ea0e0577051, abstract = {{In this issue of Journal of Endocrinology, Dr Han and colleagues report a protective effect of the glutamate dehydrogenase-activator BCH under diabetes-like conditions that impair β-cell function in both a pancreatic β-cell line and in db/db mice. Based on these observations, the authors suggest that BCH could serve as novel treatment modality in Type 2 Diabetes. The present commentary discusses the importance of the findings. Some additional questions are raised, that may be addressed in future investigations, as is some concern regarding BCH treatment of β-cell failure.}}, author = {{Göhring, Isabel and Mulder, Hindrik}}, issn = {{1479-6805}}, language = {{eng}}, number = {{3}}, pages = {{239--242}}, publisher = {{Society for Endocrinology}}, series = {{Journal of Endocrinology}}, title = {{Glutamate dehydrogenase, insulin secretion and Type 2 Diabetes. A new means to protect the pancreatic β-cell?}}, url = {{http://dx.doi.org/10.1530/JOE-11-0481}}, doi = {{10.1530/JOE-11-0481}}, volume = {{212}}, year = {{2012}}, }