Advanced

Bacterial Hydrolysis of Host Glycoproteins - Powerful Protein Modification and Efficient Nutrient Acquisition.

Garbe, Julia LU and Collin, Mattias LU (2012) In Journal of Innate Immunity 4(2). p.121-131
Abstract
Glycoproteins are ubiquitous in nature and fundamental to most biological processes, including the human immune system. The glycoprotein carbohydrate moieties, or glycans, are very diverse in their structure and composition, and have major effects on the chemical, physical and biological properties of these glycoproteins. The hydrolysis of glycoprotein glycans by bacterial glycosidases can have dramatic effects on glycoprotein function and, thereby, be beneficial for the bacteria in different ways. This review gives an introduction to the expanding field of extracellular glycosidases from bacterial pathogens with activity on host glycoproteins, describes some known and proposed consequences for the host and the bacteria and discusses some... (More)
Glycoproteins are ubiquitous in nature and fundamental to most biological processes, including the human immune system. The glycoprotein carbohydrate moieties, or glycans, are very diverse in their structure and composition, and have major effects on the chemical, physical and biological properties of these glycoproteins. The hydrolysis of glycoprotein glycans by bacterial glycosidases can have dramatic effects on glycoprotein function and, thereby, be beneficial for the bacteria in different ways. This review gives an introduction to the expanding field of extracellular glycosidases from bacterial pathogens with activity on host glycoproteins, describes some known and proposed consequences for the host and the bacteria and discusses some evolutionary and regulatory aspects of bacterial glycosidases. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Innate Immunity
volume
4
issue
2
pages
121 - 131
publisher
Karger
external identifiers
  • wos:000300758400002
  • pmid:22222876
  • scopus:84857792795
ISSN
1662-811X
DOI
10.1159/000334775
language
English
LU publication?
yes
id
445455a9-78eb-423a-9234-0dc9917bccf1 (old id 2336645)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22222876?dopt=Abstract
date added to LUP
2012-02-01 19:52:08
date last changed
2017-02-26 03:02:08
@article{445455a9-78eb-423a-9234-0dc9917bccf1,
  abstract     = {Glycoproteins are ubiquitous in nature and fundamental to most biological processes, including the human immune system. The glycoprotein carbohydrate moieties, or glycans, are very diverse in their structure and composition, and have major effects on the chemical, physical and biological properties of these glycoproteins. The hydrolysis of glycoprotein glycans by bacterial glycosidases can have dramatic effects on glycoprotein function and, thereby, be beneficial for the bacteria in different ways. This review gives an introduction to the expanding field of extracellular glycosidases from bacterial pathogens with activity on host glycoproteins, describes some known and proposed consequences for the host and the bacteria and discusses some evolutionary and regulatory aspects of bacterial glycosidases.},
  author       = {Garbe, Julia and Collin, Mattias},
  issn         = {1662-811X},
  language     = {eng},
  number       = {2},
  pages        = {121--131},
  publisher    = {Karger},
  series       = {Journal of Innate Immunity},
  title        = {Bacterial Hydrolysis of Host Glycoproteins - Powerful Protein Modification and Efficient Nutrient Acquisition.},
  url          = {http://dx.doi.org/10.1159/000334775},
  volume       = {4},
  year         = {2012},
}