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Comparison of in vitro methods of measuring mucoadhesion: Ellipsometry, tensile strength and rheological measurements.

Ivarsson, David and Wahlgren, Marie LU (2012) In Colloids and Surfaces. B, Biointerfaces 92. p.353-359
Abstract
In this work three in vitro methods for the measurement of mucoadhesion have been compared: ellipsometry, tensile strength and rheology. The conditions used for the three methods have been as similar as possible. Six different polymers were investigated: sodium carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), chitosan, polyvinyl pyrrolidone (PVP) and two cross-linked polyacrylic acids, Noveon (hydrophobically modified) and Carbopol. The results showed that PVP did not exhibit mucoadhesion according to any of the methods used. Chitosan, Noveon, Carbopol, CMC and HEC showed good mucoadhesion in the tensile strength and the rheological measurements, but not in the ellipsometry investigation. Chitosan was the only polymer showing... (More)
In this work three in vitro methods for the measurement of mucoadhesion have been compared: ellipsometry, tensile strength and rheology. The conditions used for the three methods have been as similar as possible. Six different polymers were investigated: sodium carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), chitosan, polyvinyl pyrrolidone (PVP) and two cross-linked polyacrylic acids, Noveon (hydrophobically modified) and Carbopol. The results showed that PVP did not exhibit mucoadhesion according to any of the methods used. Chitosan, Noveon, Carbopol, CMC and HEC showed good mucoadhesion in the tensile strength and the rheological measurements, but not in the ellipsometry investigation. Chitosan was the only polymer showing good mucoadhesion with the ellipsometry method. No two methods gave the same ranking of mucoadhesive strength of the polymers. The conflicting results obtained with the different methods underline the need for further improvements in existing experimental techniques and theoretical concepts for the correct assessment of mucoadhesive properties. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Colloids and Surfaces. B, Biointerfaces
volume
92
pages
353 - 359
publisher
Elsevier
external identifiers
  • wos:000300859000050
  • pmid:22209653
  • scopus:84856089110
ISSN
1873-4367
DOI
10.1016/j.colsurfb.2011.12.020
language
English
LU publication?
yes
id
29a3a173-672d-4227-ae29-c326da863292 (old id 2336793)
date added to LUP
2012-02-08 11:49:17
date last changed
2017-10-01 04:11:41
@article{29a3a173-672d-4227-ae29-c326da863292,
  abstract     = {In this work three in vitro methods for the measurement of mucoadhesion have been compared: ellipsometry, tensile strength and rheology. The conditions used for the three methods have been as similar as possible. Six different polymers were investigated: sodium carboxymethyl cellulose (CMC), hydroxyethyl cellulose (HEC), chitosan, polyvinyl pyrrolidone (PVP) and two cross-linked polyacrylic acids, Noveon (hydrophobically modified) and Carbopol. The results showed that PVP did not exhibit mucoadhesion according to any of the methods used. Chitosan, Noveon, Carbopol, CMC and HEC showed good mucoadhesion in the tensile strength and the rheological measurements, but not in the ellipsometry investigation. Chitosan was the only polymer showing good mucoadhesion with the ellipsometry method. No two methods gave the same ranking of mucoadhesive strength of the polymers. The conflicting results obtained with the different methods underline the need for further improvements in existing experimental techniques and theoretical concepts for the correct assessment of mucoadhesive properties.},
  author       = {Ivarsson, David and Wahlgren, Marie},
  issn         = {1873-4367},
  language     = {eng},
  pages        = {353--359},
  publisher    = {Elsevier},
  series       = {Colloids and Surfaces. B, Biointerfaces},
  title        = {Comparison of in vitro methods of measuring mucoadhesion: Ellipsometry, tensile strength and rheological measurements.},
  url          = {http://dx.doi.org/10.1016/j.colsurfb.2011.12.020},
  volume       = {92},
  year         = {2012},
}