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Selective antibody reactivity with peptides from human endogenous retroviruses and nonviral poly(amino acids) in patients with systemic lupus erythematosus

Bengtsson, Ders LU ; Blomberg, Jonas ; Nived, Ola LU ; Pipkorn, Rüdiger ; Toth, Lajos and Sturfelt, Gunnar LU (1996) In Arthritis and Rheumatism 39(10). p.1654-1663
Abstract

Objective. To investigate antibody responses to a broad panel of peptides derived from human endogenous retroviruses (HERVs) among unselected patients with systemic lupus erythematosus (SLE). Methods. In sera obtained from 69 patients with SLE and healthy blood donors, immunoassay was used to measure levels of antibody against synthetic peptides derived from HERVs, exogenous retroviruses, and nonviral poly(amino acids). Results. Measurement by immunoassay revealed increased frequencies of antiretroviral antibodies against 2 peptides derived from the env gene of the type C-like class, which includes ERV-9 and HERV-H, and against 2 peptides from the gag region of human T lymphotropic virus type I-related endogenous sequence 1, in patients... (More)

Objective. To investigate antibody responses to a broad panel of peptides derived from human endogenous retroviruses (HERVs) among unselected patients with systemic lupus erythematosus (SLE). Methods. In sera obtained from 69 patients with SLE and healthy blood donors, immunoassay was used to measure levels of antibody against synthetic peptides derived from HERVs, exogenous retroviruses, and nonviral poly(amino acids). Results. Measurement by immunoassay revealed increased frequencies of antiretroviral antibodies against 2 peptides derived from the env gene of the type C-like class, which includes ERV-9 and HERV-H, and against 2 peptides from the gag region of human T lymphotropic virus type I-related endogenous sequence 1, in patients with SLE. Antibodies to 2 nonviral peptides, polyhistidine and polyproline, were also overrepresented in patient sera. In 1 patient, longitudinal data obtained over a period of 12 years indicated that the concentrations of certain antiretroviral antibodies varied according to disease activity. Conclusion. Reactivity to certain type C HERV-derived antigens was found among patients with SLE. This reactivity could be explained by increased exposure to cross-reactive epitopes from essentially complete type C HERVs.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis and Rheumatism
volume
39
issue
10
pages
10 pages
publisher
John Wiley and Sons
external identifiers
  • pmid:8843855
  • scopus:10144227098
ISSN
0004-3591
DOI
10.1002/art.1780391007
language
English
LU publication?
yes
id
233eec4e-89fe-4edd-8a04-ae6fcf54597c
date added to LUP
2019-05-23 10:29:05
date last changed
2021-02-17 05:13:40
@article{233eec4e-89fe-4edd-8a04-ae6fcf54597c,
  abstract     = {<p>Objective. To investigate antibody responses to a broad panel of peptides derived from human endogenous retroviruses (HERVs) among unselected patients with systemic lupus erythematosus (SLE). Methods. In sera obtained from 69 patients with SLE and healthy blood donors, immunoassay was used to measure levels of antibody against synthetic peptides derived from HERVs, exogenous retroviruses, and nonviral poly(amino acids). Results. Measurement by immunoassay revealed increased frequencies of antiretroviral antibodies against 2 peptides derived from the env gene of the type C-like class, which includes ERV-9 and HERV-H, and against 2 peptides from the gag region of human T lymphotropic virus type I-related endogenous sequence 1, in patients with SLE. Antibodies to 2 nonviral peptides, polyhistidine and polyproline, were also overrepresented in patient sera. In 1 patient, longitudinal data obtained over a period of 12 years indicated that the concentrations of certain antiretroviral antibodies varied according to disease activity. Conclusion. Reactivity to certain type C HERV-derived antigens was found among patients with SLE. This reactivity could be explained by increased exposure to cross-reactive epitopes from essentially complete type C HERVs.</p>},
  author       = {Bengtsson, Ders and Blomberg, Jonas and Nived, Ola and Pipkorn, Rüdiger and Toth, Lajos and Sturfelt, Gunnar},
  issn         = {0004-3591},
  language     = {eng},
  month        = {01},
  number       = {10},
  pages        = {1654--1663},
  publisher    = {John Wiley and Sons},
  series       = {Arthritis and Rheumatism},
  title        = {Selective antibody reactivity with peptides from human endogenous retroviruses and nonviral poly(amino acids) in patients with systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1002/art.1780391007},
  doi          = {10.1002/art.1780391007},
  volume       = {39},
  year         = {1996},
}