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The global distribution and evolution of deoxyribonucleoside kinases in bacteria

Konrad, Anke; Yarunova, Ekaterina; Tinta, Tinkara; Piskur, Jure LU and Liberles, David A. (2012) In Gene 492(1). p.117-120
Abstract
Deoxyribonucleoside kinases (dNKs) are important to DNA metabolism, especially in environments where nucleosides are freely available to be absorbed and used for the salvage pathway. Little has previously been known about the complement of dNKs in different bacterial genomes. However, it was believed that Gram-negative bacteria had a single dNK, while Gram-positive bacteria possessed several. An analysis of 992 fully sequenced bacterial genomes, including both Gram-positive and Gram-negative organisms, was conducted to investigate the phylogenetic relationship of all TK1-like and non-TK1-like dNKs. It was illustrated that both gene families evolved through a number of duplications and horizontal gene transfers, leading to the presence of... (More)
Deoxyribonucleoside kinases (dNKs) are important to DNA metabolism, especially in environments where nucleosides are freely available to be absorbed and used for the salvage pathway. Little has previously been known about the complement of dNKs in different bacterial genomes. However, it was believed that Gram-negative bacteria had a single dNK, while Gram-positive bacteria possessed several. An analysis of 992 fully sequenced bacterial genomes, including both Gram-positive and Gram-negative organisms, was conducted to investigate the phylogenetic relationship of all TK1-like and non-TK1-like dNKs. It was illustrated that both gene families evolved through a number of duplications and horizontal gene transfers, leading to the presence of multiple dNKs in different types of bacteria. The findings of this study provide a backbone for further studies into the evolution of the interplay between the de novo and salvage pathways in DNA synthesis with respect to environmental availability of deoxyribonucleosides and metabolic processes generating the provisions of different dNTPs. (C) 2011 Elsevier B.V. All rights reserved. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Deoxyribonucleoside kinase, Evolution, Phylogeny, Salvage pathway, Gene, duplication, Horizontal transfer
in
Gene
volume
492
issue
1
pages
117 - 120
publisher
Elsevier
external identifiers
  • wos:000299248000013
  • scopus:84155195091
ISSN
1879-0038
DOI
10.1016/j.gene.2011.10.039
language
English
LU publication?
yes
id
45c03055-7396-43a8-95ab-ee93e49524e7 (old id 2355330)
date added to LUP
2012-02-23 08:56:57
date last changed
2017-01-01 05:28:16
@article{45c03055-7396-43a8-95ab-ee93e49524e7,
  abstract     = {Deoxyribonucleoside kinases (dNKs) are important to DNA metabolism, especially in environments where nucleosides are freely available to be absorbed and used for the salvage pathway. Little has previously been known about the complement of dNKs in different bacterial genomes. However, it was believed that Gram-negative bacteria had a single dNK, while Gram-positive bacteria possessed several. An analysis of 992 fully sequenced bacterial genomes, including both Gram-positive and Gram-negative organisms, was conducted to investigate the phylogenetic relationship of all TK1-like and non-TK1-like dNKs. It was illustrated that both gene families evolved through a number of duplications and horizontal gene transfers, leading to the presence of multiple dNKs in different types of bacteria. The findings of this study provide a backbone for further studies into the evolution of the interplay between the de novo and salvage pathways in DNA synthesis with respect to environmental availability of deoxyribonucleosides and metabolic processes generating the provisions of different dNTPs. (C) 2011 Elsevier B.V. All rights reserved.},
  author       = {Konrad, Anke and Yarunova, Ekaterina and Tinta, Tinkara and Piskur, Jure and Liberles, David A.},
  issn         = {1879-0038},
  keyword      = {Deoxyribonucleoside kinase,Evolution,Phylogeny,Salvage pathway,Gene,duplication,Horizontal transfer},
  language     = {eng},
  number       = {1},
  pages        = {117--120},
  publisher    = {Elsevier},
  series       = {Gene},
  title        = {The global distribution and evolution of deoxyribonucleoside kinases in bacteria},
  url          = {http://dx.doi.org/10.1016/j.gene.2011.10.039},
  volume       = {492},
  year         = {2012},
}