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Longitudinal evaluation of cartilage after osteochondral autogenous transfer with delayed gadolinium-enhanced MRI of the cartilage (dGEMRIC)

Shirai, Takaaki; Kobayashi, Masahiko; Nakamura, Shinichiro; Arai, Ryuzo; Nishitani, Kohei; Satake, Tsuyoshi; Dahlberg, Leif LU ; Kuroki, Hiroshi; Nakagawa, Yasuaki and Okada, Tomohisa, et al. (2012) In Journal of Orthopaedic Research 30(2). p.221-225
Abstract
The aim was to use repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) to estimate glycosaminoglycan (GAG) content in reparative cartilage after osteochondral autogenous transfer (OAT). The study group comprised 7 knees of 7 patients that were examined three times by dGEMRIC, at 3, 6, and 12 months using a 1.5 Tesla MRI system in both OAT operated and nonoperated condyles at 90 min after the injection. The gadolinium diethylene triamine pentaacetic acid (Gd-DTPA)2- containing contrast medium (0.2 mmols/kg) was injected intravenously. The mean T1 values of the plug cartilage at 3, 6, and 12 months after OAT was 230 +/- 40, 213 +/- 31, and 230 +/- 23 ms (mean +/- SD), respectively. There were differences... (More)
The aim was to use repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) to estimate glycosaminoglycan (GAG) content in reparative cartilage after osteochondral autogenous transfer (OAT). The study group comprised 7 knees of 7 patients that were examined three times by dGEMRIC, at 3, 6, and 12 months using a 1.5 Tesla MRI system in both OAT operated and nonoperated condyles at 90 min after the injection. The gadolinium diethylene triamine pentaacetic acid (Gd-DTPA)2- containing contrast medium (0.2 mmols/kg) was injected intravenously. The mean T1 values of the plug cartilage at 3, 6, and 12 months after OAT was 230 +/- 40, 213 +/- 31, and 230 +/- 23 ms (mean +/- SD), respectively. There were differences between the plug and control cartilage at 3 (p<0.01) and 12 (p<0.05) months after OAT, but not at 6 months (p=0.089). No T1 changes were detected between the plug cartilage at the different time points after OAT. The fact that the GAG content of the OAT plugs were maintained for 12-month study period suggest that no major deterioration of load-bearing properties occurs in the cartilage after the OAT. (C) 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:221225, 2012 (Less)
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published
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keywords
cartilage, osteochondral autogenous transfer (OAT), dGEMRIC, MRI, knee
in
Journal of Orthopaedic Research
volume
30
issue
2
pages
221 - 225
publisher
John Wiley & Sons
external identifiers
  • wos:000298581200009
  • scopus:83855160911
ISSN
1554-527X
DOI
10.1002/jor.21514
language
English
LU publication?
yes
id
98f18696-5c65-4c6f-987e-e461e5daf6c8 (old id 2358545)
date added to LUP
2012-03-01 11:30:56
date last changed
2017-08-13 03:08:26
@article{98f18696-5c65-4c6f-987e-e461e5daf6c8,
  abstract     = {The aim was to use repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) to estimate glycosaminoglycan (GAG) content in reparative cartilage after osteochondral autogenous transfer (OAT). The study group comprised 7 knees of 7 patients that were examined three times by dGEMRIC, at 3, 6, and 12 months using a 1.5 Tesla MRI system in both OAT operated and nonoperated condyles at 90 min after the injection. The gadolinium diethylene triamine pentaacetic acid (Gd-DTPA)2- containing contrast medium (0.2 mmols/kg) was injected intravenously. The mean T1 values of the plug cartilage at 3, 6, and 12 months after OAT was 230 +/- 40, 213 +/- 31, and 230 +/- 23 ms (mean +/- SD), respectively. There were differences between the plug and control cartilage at 3 (p&lt;0.01) and 12 (p&lt;0.05) months after OAT, but not at 6 months (p=0.089). No T1 changes were detected between the plug cartilage at the different time points after OAT. The fact that the GAG content of the OAT plugs were maintained for 12-month study period suggest that no major deterioration of load-bearing properties occurs in the cartilage after the OAT. (C) 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:221225, 2012},
  author       = {Shirai, Takaaki and Kobayashi, Masahiko and Nakamura, Shinichiro and Arai, Ryuzo and Nishitani, Kohei and Satake, Tsuyoshi and Dahlberg, Leif and Kuroki, Hiroshi and Nakagawa, Yasuaki and Okada, Tomohisa and Togashi, Kaori and Nakamura, Takashi},
  issn         = {1554-527X},
  keyword      = {cartilage,osteochondral autogenous transfer (OAT),dGEMRIC,MRI,knee},
  language     = {eng},
  number       = {2},
  pages        = {221--225},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Orthopaedic Research},
  title        = {Longitudinal evaluation of cartilage after osteochondral autogenous transfer with delayed gadolinium-enhanced MRI of the cartilage (dGEMRIC)},
  url          = {http://dx.doi.org/10.1002/jor.21514},
  volume       = {30},
  year         = {2012},
}