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The non-random location of human oncogenes and tumour suppressor genes

Antonio, L D and Widegren, Bengt LU (2005) In Caryologia 58(1). p.1-14
Abstract
We have analysed 994 sites for oncogenes and tumour suppressor genes located within human chromosome bands. The data presented disclose that: 1) These cancer genes build ridges as well as hot spots, which are not related to the position of other types of genes present in these chromosomes. 2) The frequency of cancer genes is not directly related to chromosome length, to the number of DNA bases per chromosome or to the number of structural genes present in each chromosome. 3) Suppressor genes tend to occupy the same location as oncogenes. 4) Several cancer genes occur in as many as 15 different sites spread over 10 different chromosomes. 5) The main feature of the distribution of both oncogenes and suppressors, is that they tend to be... (More)
We have analysed 994 sites for oncogenes and tumour suppressor genes located within human chromosome bands. The data presented disclose that: 1) These cancer genes build ridges as well as hot spots, which are not related to the position of other types of genes present in these chromosomes. 2) The frequency of cancer genes is not directly related to chromosome length, to the number of DNA bases per chromosome or to the number of structural genes present in each chromosome. 3) Suppressor genes tend to occupy the same location as oncogenes. 4) Several cancer genes occur in as many as 15 different sites spread over 10 different chromosomes. 5) The main feature of the distribution of both oncogenes and suppressors, is that they tend to be located near telomeres. Moreover, their numbers decrease from the telomere to the centromere building a distinct gradient. The difference is statistically significant. The present evidence, taken together, indicates that the telomeric territory might be a preferential location of cancer related genes and thereby also of stem cell genes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
suppressors, turnout, telomeres, oncogenes, gene territory, nucleolus organizers
in
Caryologia
volume
58
issue
1
pages
1 - 14
publisher
UNIV FLORENCE BOTANY INST
external identifiers
  • wos:000229881700001
  • scopus:33751301632
ISSN
0008-7114
language
English
LU publication?
yes
id
5c59715c-fcbc-4431-a2e8-f93d29afcc47 (old id 235899)
date added to LUP
2007-09-13 17:58:00
date last changed
2017-01-01 06:56:33
@article{5c59715c-fcbc-4431-a2e8-f93d29afcc47,
  abstract     = {We have analysed 994 sites for oncogenes and tumour suppressor genes located within human chromosome bands. The data presented disclose that: 1) These cancer genes build ridges as well as hot spots, which are not related to the position of other types of genes present in these chromosomes. 2) The frequency of cancer genes is not directly related to chromosome length, to the number of DNA bases per chromosome or to the number of structural genes present in each chromosome. 3) Suppressor genes tend to occupy the same location as oncogenes. 4) Several cancer genes occur in as many as 15 different sites spread over 10 different chromosomes. 5) The main feature of the distribution of both oncogenes and suppressors, is that they tend to be located near telomeres. Moreover, their numbers decrease from the telomere to the centromere building a distinct gradient. The difference is statistically significant. The present evidence, taken together, indicates that the telomeric territory might be a preferential location of cancer related genes and thereby also of stem cell genes.},
  author       = {Antonio, L D and Widegren, Bengt},
  issn         = {0008-7114},
  keyword      = {suppressors,turnout,telomeres,oncogenes,gene territory,nucleolus organizers},
  language     = {eng},
  number       = {1},
  pages        = {1--14},
  publisher    = {UNIV FLORENCE BOTANY INST},
  series       = {Caryologia},
  title        = {The non-random location of human oncogenes and tumour suppressor genes},
  volume       = {58},
  year         = {2005},
}