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Contact Allergy to Two Aluminum Salts in Consecutively Patch-Tested Dermatitis Patients

Siemund, Ingrid LU ; Dahlin, Jakob LU ; Hindsén, Monica LU ; Zimerson, Erik LU ; Antelmi, Annarita LU ; Hamnerius, Nils LU ; Hauksson, Inese LU ; Isaksson, Marléne LU ; Pontén, Ann LU and Mowitz, Martin LU , et al. (2022) In Dermatitis 33(1). p.31-35
Abstract

Background: Recently, aluminum chloride hexahydrate (ACH) 10.0% petrolatum (pet) was recommended for patch testing to detect aluminum contact allergy. Aluminum lactate (AL) may be as reliable a test substance as ACH. Objective: We aimed to investigate the frequencies of aluminum allergy when ACH and AL were used in patch testing consecutive patients. Methods: Petrolatum preparations of ACH 10.0% and AL 12.0% were added to the baseline series in 2010-2017. Aluminum chloride hexahydrate 10.0% pet was added to the children baseline series from July 1, 2012, to December 31, 2017. Results: A total of 5448 patients were patch tested with the extended baseline series and 196 children with the extended children baseline series. Forty-eight of... (More)

Background: Recently, aluminum chloride hexahydrate (ACH) 10.0% petrolatum (pet) was recommended for patch testing to detect aluminum contact allergy. Aluminum lactate (AL) may be as reliable a test substance as ACH. Objective: We aimed to investigate the frequencies of aluminum allergy when ACH and AL were used in patch testing consecutive patients. Methods: Petrolatum preparations of ACH 10.0% and AL 12.0% were added to the baseline series in 2010-2017. Aluminum chloride hexahydrate 10.0% pet was added to the children baseline series from July 1, 2012, to December 31, 2017. Results: A total of 5448 patients were patch tested with the extended baseline series and 196 children with the extended children baseline series. Forty-eight of the 5448 adults (0.9%) and 10 of the 196 children (5.1%) were diagnosed with aluminum contact allergy. A significant difference was found between the aluminum allergy frequencies in children and adults patch tested with ACH in 2013-2017 (P < 0.001). The difference between the frequencies of contact allergies for the 2 aluminum salts is not statistically significant. Conclusions: Patch testing with ACH and AL demonstrated similar contact allergy frequencies. To detect aluminum allergy, patch testing with ACH 10.0% pet is recommended. Aluminum chloride hexahydrate 10.0% pet should be considered for inclusion in baseline series for patch testing adults and children.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis
volume
33
issue
1
pages
5 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:85123810190
  • pmid:34570735
ISSN
1710-3568
DOI
10.1097/DER.0000000000000787
language
English
LU publication?
yes
id
235da04a-00c8-4dde-8383-07a4981fba09
date added to LUP
2022-04-11 15:11:40
date last changed
2024-06-15 10:09:34
@article{235da04a-00c8-4dde-8383-07a4981fba09,
  abstract     = {{<p>Background: Recently, aluminum chloride hexahydrate (ACH) 10.0% petrolatum (pet) was recommended for patch testing to detect aluminum contact allergy. Aluminum lactate (AL) may be as reliable a test substance as ACH. Objective: We aimed to investigate the frequencies of aluminum allergy when ACH and AL were used in patch testing consecutive patients. Methods: Petrolatum preparations of ACH 10.0% and AL 12.0% were added to the baseline series in 2010-2017. Aluminum chloride hexahydrate 10.0% pet was added to the children baseline series from July 1, 2012, to December 31, 2017. Results: A total of 5448 patients were patch tested with the extended baseline series and 196 children with the extended children baseline series. Forty-eight of the 5448 adults (0.9%) and 10 of the 196 children (5.1%) were diagnosed with aluminum contact allergy. A significant difference was found between the aluminum allergy frequencies in children and adults patch tested with ACH in 2013-2017 (P &lt; 0.001). The difference between the frequencies of contact allergies for the 2 aluminum salts is not statistically significant. Conclusions: Patch testing with ACH and AL demonstrated similar contact allergy frequencies. To detect aluminum allergy, patch testing with ACH 10.0% pet is recommended. Aluminum chloride hexahydrate 10.0% pet should be considered for inclusion in baseline series for patch testing adults and children.</p>}},
  author       = {{Siemund, Ingrid and Dahlin, Jakob and Hindsén, Monica and Zimerson, Erik and Antelmi, Annarita and Hamnerius, Nils and Hauksson, Inese and Isaksson, Marléne and Pontén, Ann and Mowitz, Martin and Svedman, Cecilia and Bruze, Magnus}},
  issn         = {{1710-3568}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{31--35}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Dermatitis}},
  title        = {{Contact Allergy to Two Aluminum Salts in Consecutively Patch-Tested Dermatitis Patients}},
  url          = {{http://dx.doi.org/10.1097/DER.0000000000000787}},
  doi          = {{10.1097/DER.0000000000000787}},
  volume       = {{33}},
  year         = {{2022}},
}