Advanced

Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology

Bastlund, JF; Jennum, P; Mohapel, Paul LU ; Penschuck, S and Watson, WP (2005) In Epilepsia 46(6). p.934-938
Abstract
Purpose: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats. Methods: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) activity and spontaneous reoccurring seizures (SRSs). Results: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and... (More)
Purpose: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats. Methods: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) activity and spontaneous reoccurring seizures (SRSs). Results: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep. Conclusions: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
seizures, radiotelemetry, electroencephalogram, neurodegeneration, sleep architecture
in
Epilepsia
volume
46
issue
6
pages
934 - 938
publisher
Wiley-Blackwell
external identifiers
  • pmid:15946334
  • wos:000229802200014
  • scopus:20544472035
ISSN
0013-9580
DOI
10.1111/j.1528-1167.2005.63204.x
language
English
LU publication?
yes
id
7e4b86e6-3df1-4ecf-abdf-e3a1a9e3edcf (old id 236217)
date added to LUP
2007-08-24 11:43:23
date last changed
2017-08-13 03:34:36
@article{7e4b86e6-3df1-4ecf-abdf-e3a1a9e3edcf,
  abstract     = {Purpose: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats. Methods: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) activity and spontaneous reoccurring seizures (SRSs). Results: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep. Conclusions: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology.},
  author       = {Bastlund, JF and Jennum, P and Mohapel, Paul and Penschuck, S and Watson, WP},
  issn         = {0013-9580},
  keyword      = {seizures,radiotelemetry,electroencephalogram,neurodegeneration,sleep architecture},
  language     = {eng},
  number       = {6},
  pages        = {934--938},
  publisher    = {Wiley-Blackwell},
  series       = {Epilepsia},
  title        = {Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology},
  url          = {http://dx.doi.org/10.1111/j.1528-1167.2005.63204.x},
  volume       = {46},
  year         = {2005},
}