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Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

Broderick, Peter; Chubb, Daniel; Johnson, David C.; Weinhold, Niels; Foersti, Asta; Lloyd, Amy; Olver, Bianca; Ma, Yussanne P.; Dobbins, Sara E. and Walker, Brian A., et al. (2012) In Nature Genetics 44(1). p.58-83
Abstract
To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 x 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 x 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 x 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.
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publication status
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Nature Genetics
volume
44
issue
1
pages
58 - 83
publisher
Nature Publishing Group
external identifiers
  • wos:000298664000014
  • scopus:84655166569
ISSN
1546-1718
DOI
10.1038/ng.993
language
English
LU publication?
yes
id
2f3364fa-d7e0-4b4b-b489-d68cd19ac12b (old id 2362569)
date added to LUP
2012-03-01 12:11:00
date last changed
2017-10-01 04:11:35
@article{2f3364fa-d7e0-4b4b-b489-d68cd19ac12b,
  abstract     = {To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 x 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 x 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 x 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.},
  author       = {Broderick, Peter and Chubb, Daniel and Johnson, David C. and Weinhold, Niels and Foersti, Asta and Lloyd, Amy and Olver, Bianca and Ma, Yussanne P. and Dobbins, Sara E. and Walker, Brian A. and Davies, Faith E. and Gregory, Walter A. and Child, J. Anthony and Ross, Fiona M. and Jackson, Graham H. and Neben, Kai and Jauch, Anna and Hoffmann, Per and Muehleisen, Thomas W. and Noethen, Markus M. and Moebus, Susanne and Tomlinson, Ian P. and Goldschmidt, Hartmut and Hemminki, Kari and Morgan, Gareth J. and Houlston, Richard S.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {1},
  pages        = {58--83},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk},
  url          = {http://dx.doi.org/10.1038/ng.993},
  volume       = {44},
  year         = {2012},
}