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Is erythromycin therapy teratogenic in humans?

Källén, Bengt LU ; Olausson, PO and Danielsson, BR (2005) In Reproductive Toxicology 20(2). p.209-214
Abstract
The possible teratogenic effect of erythromycin therapy, noted previously, was studied. Women who had taken erythromycin or penicillin V in early pregnancy and their infants were studied, using the Swedish Medical Birth Register where information on drug use during pregnancy was recorded based on interviews in early pregnancy. The risk for any congenital malformation after erythromycin therapy (but not after penicillin V therapy) was increased (odds ratio 1.24, 95% confidence interval: 1.01-1.51) and this was due to an effect on cardiovascular malformations (odds ratio 1.92, 95% CI: 1.37-2.68). There was also an indicated increased risk for pyloric stenosis (risk ratio 3.0, 95% CI: 1.1-8.5 after exposure in early pregnancy). Various... (More)
The possible teratogenic effect of erythromycin therapy, noted previously, was studied. Women who had taken erythromycin or penicillin V in early pregnancy and their infants were studied, using the Swedish Medical Birth Register where information on drug use during pregnancy was recorded based on interviews in early pregnancy. The risk for any congenital malformation after erythromycin therapy (but not after penicillin V therapy) was increased (odds ratio 1.24, 95% confidence interval: 1.01-1.51) and this was due to an effect on cardiovascular malformations (odds ratio 1.92, 95% CI: 1.37-2.68). There was also an indicated increased risk for pyloric stenosis (risk ratio 3.0, 95% CI: 1.1-8.5 after exposure in early pregnancy). Various explanations to the finding are discussed, one of them linked to the fact that erythromycin inhibits a specific cardiac potassium channel (IKr) which seems to play a major role in cardiac rhythm regulation in the early embryo. Potent blocking drugs cause as a class effect cardiac defects in animal experiments. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epidemiology, pyloric stenosis, cardiovascular defects, erythromycin, teratogenicity, IKr, hERG
in
Reproductive Toxicology
volume
20
issue
2
pages
209 - 214
publisher
Elsevier
external identifiers
  • wos:000229647200005
  • scopus:19444367335
ISSN
1873-1708
DOI
10.1016/j.reprotox.2005.01.010
language
English
LU publication?
yes
id
94f13813-2d64-4b48-a3bd-1b813563863c (old id 236388)
date added to LUP
2007-08-15 11:32:20
date last changed
2017-11-19 04:11:35
@article{94f13813-2d64-4b48-a3bd-1b813563863c,
  abstract     = {The possible teratogenic effect of erythromycin therapy, noted previously, was studied. Women who had taken erythromycin or penicillin V in early pregnancy and their infants were studied, using the Swedish Medical Birth Register where information on drug use during pregnancy was recorded based on interviews in early pregnancy. The risk for any congenital malformation after erythromycin therapy (but not after penicillin V therapy) was increased (odds ratio 1.24, 95% confidence interval: 1.01-1.51) and this was due to an effect on cardiovascular malformations (odds ratio 1.92, 95% CI: 1.37-2.68). There was also an indicated increased risk for pyloric stenosis (risk ratio 3.0, 95% CI: 1.1-8.5 after exposure in early pregnancy). Various explanations to the finding are discussed, one of them linked to the fact that erythromycin inhibits a specific cardiac potassium channel (IKr) which seems to play a major role in cardiac rhythm regulation in the early embryo. Potent blocking drugs cause as a class effect cardiac defects in animal experiments.},
  author       = {Källén, Bengt and Olausson, PO and Danielsson, BR},
  issn         = {1873-1708},
  keyword      = {epidemiology,pyloric stenosis,cardiovascular defects,erythromycin,teratogenicity,IKr,hERG},
  language     = {eng},
  number       = {2},
  pages        = {209--214},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Is erythromycin therapy teratogenic in humans?},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2005.01.010},
  volume       = {20},
  year         = {2005},
}