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Standardization and Utilization of Biobank Resources in Clinical Protein Sciene with Examples of Emerging Applications

Marko-Varga, György LU ; Végvári, Ákos LU ; Welinder, Charlotte LU ; Lindberg, Henrik LU ; Rezeli, Melinda LU ; Edula, Goutham; Svensson, Katrin LU ; Belting, Mattias LU ; Laurell, Thomas LU and Fehniger, Thomas LU (2012) In Journal of Proteome Research 11(11). p.5124-5134
Abstract
Biobanks are a major resource to access and measure biological constituents that can be used to monitor the status of health and disease, both in unique individual samples and within populations. Most “omic” activities rely on access to these collections of stored samples to provide the basis for establishing the ranges and frequencies of expression. Furthermore, information about the relative abundance and form of protein constituents found in stored samples provides an important historical index for comparative studies of inherited, epidemic, and developing disease. Standardizations of sample quality, form, and analysis are an important unmet need and requirement for gaining full benefit from collected samples. Coupled to this standard... (More)
Biobanks are a major resource to access and measure biological constituents that can be used to monitor the status of health and disease, both in unique individual samples and within populations. Most “omic” activities rely on access to these collections of stored samples to provide the basis for establishing the ranges and frequencies of expression. Furthermore, information about the relative abundance and form of protein constituents found in stored samples provides an important historical index for comparative studies of inherited, epidemic, and developing disease. Standardizations of sample quality, form, and analysis are an important unmet need and requirement for gaining full benefit from collected samples. Coupled to this standard is the provision of annotation describing clinical status and metadata of measurements of clinical phenotype that characterizes the sample. Today we have not yet achieved consensus on how to collect, manage, and build biobank archives in order to reach goals where these efforts are translated into value for the patient. Several initiatives (OBBR, ISBER, BBMRI) that disseminate best practice examples for biobanking are expected to play an important role in ensuring the need to preserve the sample integrity of biosamples stored for periods that reach one or several decades. These developments will be of great value and importance to programs such as the Chromosome Human Protein Project (C-HPP) that will associate protein expression in healthy and disease states with genetic foci along of each of the human chromosomes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biobank, Healthcare, Disease, Biomarkers, Protein, Human Proteome Project, Biological specimen banks, Biological Specimen Banks/ethics, Biological Specimen Banks/legislation & jurisprudence, Biomedical Research/ethics, Ethical review, Government regulation, Humans, Informed consent, Tissue donors, Ethics
in
Journal of Proteome Research
volume
11
issue
11
pages
5124 - 5134
publisher
The American Chemical Society
external identifiers
  • wos:000311190600002
  • scopus:84868326502
ISSN
1535-3893
DOI
10.1021/pr300185k
language
English
LU publication?
yes
id
18d54203-9395-47d4-9729-7085619680d3 (old id 2364968)
date added to LUP
2012-05-28 13:35:08
date last changed
2017-08-06 03:18:23
@article{18d54203-9395-47d4-9729-7085619680d3,
  abstract     = {Biobanks are a major resource to access and measure biological constituents that can be used to monitor the status of health and disease, both in unique individual samples and within populations. Most “omic” activities rely on access to these collections of stored samples to provide the basis for establishing the ranges and frequencies of expression. Furthermore, information about the relative abundance and form of protein constituents found in stored samples provides an important historical index for comparative studies of inherited, epidemic, and developing disease. Standardizations of sample quality, form, and analysis are an important unmet need and requirement for gaining full benefit from collected samples. Coupled to this standard is the provision of annotation describing clinical status and metadata of measurements of clinical phenotype that characterizes the sample. Today we have not yet achieved consensus on how to collect, manage, and build biobank archives in order to reach goals where these efforts are translated into value for the patient. Several initiatives (OBBR, ISBER, BBMRI) that disseminate best practice examples for biobanking are expected to play an important role in ensuring the need to preserve the sample integrity of biosamples stored for periods that reach one or several decades. These developments will be of great value and importance to programs such as the Chromosome Human Protein Project (C-HPP) that will associate protein expression in healthy and disease states with genetic foci along of each of the human chromosomes.},
  author       = {Marko-Varga, György and Végvári, Ákos and Welinder, Charlotte and Lindberg, Henrik and Rezeli, Melinda and Edula, Goutham and Svensson, Katrin and Belting, Mattias and Laurell, Thomas and Fehniger, Thomas},
  issn         = {1535-3893},
  keyword      = {Biobank,Healthcare,Disease,Biomarkers,Protein,Human Proteome Project,Biological specimen banks,Biological Specimen Banks/ethics,Biological Specimen Banks/legislation & jurisprudence,Biomedical Research/ethics,Ethical review,Government regulation,Humans,Informed consent,Tissue donors,Ethics},
  language     = {eng},
  number       = {11},
  pages        = {5124--5134},
  publisher    = {The American Chemical Society},
  series       = {Journal of Proteome Research},
  title        = {Standardization and Utilization of Biobank Resources in Clinical Protein Sciene with Examples of Emerging Applications},
  url          = {http://dx.doi.org/10.1021/pr300185k},
  volume       = {11},
  year         = {2012},
}