The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study.
Larsson, Staffan LU
; Englund, Martin
LU
; Struglics, André
LU
and Lohmander, Stefan
LU
(2012)
In Osteoarthritis and Cartilage
20(5).
p.388-395
- Abstract
- OBJECTIVE: To investigate whether change in concentrations over time of aggrecanase generated ARGS-aggrecan in synovial fluid (SF ARGS) associates with progression of radiographic knee Osteoarthritis (OA) and patient-reported outcome in subjects with previous meniscectomy.
METHODS: We studied 141 subjects at two time points after meniscectomy. Time point A was on average 18years after meniscectomy, time point B was on average 7.5years later; 74 subjects had SF available from both examinations. We measured SF ARGS by an electrochemiluminescence immunoassay, graded radiographic features of tibiofemoral or patellofemoral OA according to the Osteoarthritis Research Society International (OARSI) atlas, and scored... (More) - OBJECTIVE: To investigate whether change in concentrations over time of aggrecanase generated ARGS-aggrecan in synovial fluid (SF ARGS) associates with progression of radiographic knee Osteoarthritis (OA) and patient-reported outcome in subjects with previous meniscectomy.
METHODS: We studied 141 subjects at two time points after meniscectomy. Time point A was on average 18years after meniscectomy, time point B was on average 7.5years later; 74 subjects had SF available from both examinations. We measured SF ARGS by an electrochemiluminescence immunoassay, graded radiographic features of tibiofemoral or patellofemoral OA according to the Osteoarthritis Research Society International (OARSI) atlas, and scored patient-reported outcomes using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Using logistic regression (adjusted for age, gender, body mass index, time between examinations, and SF ARGS at first examination) we assessed associations between change in SF ARGS between first and second examinations and progression of radiographic OA and KOOS.
RESULTS: In subjects with decreasing SF ARGS between examinations, the likelihood of loss of joint space and worsening of KOOS pain between examinations was increased 6- and 4-fold respectively compared to those increasing in SF ARGS (OR 5.72; 95% CI 1.53-21.4 and 3.66; 1.01-13.2, respectively). No significant associations were seen between decreasing SF ARGS and progression of osteophytes (OR 0.88; 0.28-2.78), or for patient-reported outcomes other than KOOS pain.
CONCLUSION: Having decreasing levels of SF ARGS over time was associated with an increased risk of loss of joint space and pain worsening, but showed no association with other patient-reported outcomes or osteophyte progression. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2366955
- author
- Larsson, Staffan
LU
; Englund, Martin
LU
; Struglics, André
LU
and Lohmander, Stefan
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Osteoarthritis and Cartilage
- volume
- 20
- issue
- 5
- pages
- 388 - 395
- publisher
- Elsevier
- external identifiers
-
- wos:000303297100008
- pmid:22330175
- scopus:84859423872
- pmid:22330175
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2012.02.001
- language
- English
- LU publication?
- yes
- id
- 6da89eda-874e-47e3-9acb-057659a7969a (old id 2366955)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22330175?dopt=Abstract
- date added to LUP
- 2016-04-04 06:58:14
- date last changed
- 2024-01-11 23:37:32
@article{6da89eda-874e-47e3-9acb-057659a7969a,
abstract = {{OBJECTIVE: To investigate whether change in concentrations over time of aggrecanase generated ARGS-aggrecan in synovial fluid (SF ARGS) associates with progression of radiographic knee Osteoarthritis (OA) and patient-reported outcome in subjects with previous meniscectomy. <br/><br>
<br/><br>
METHODS: We studied 141 subjects at two time points after meniscectomy. Time point A was on average 18years after meniscectomy, time point B was on average 7.5years later; 74 subjects had SF available from both examinations. We measured SF ARGS by an electrochemiluminescence immunoassay, graded radiographic features of tibiofemoral or patellofemoral OA according to the Osteoarthritis Research Society International (OARSI) atlas, and scored patient-reported outcomes using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Using logistic regression (adjusted for age, gender, body mass index, time between examinations, and SF ARGS at first examination) we assessed associations between change in SF ARGS between first and second examinations and progression of radiographic OA and KOOS. <br/><br>
<br/><br>
RESULTS: In subjects with decreasing SF ARGS between examinations, the likelihood of loss of joint space and worsening of KOOS pain between examinations was increased 6- and 4-fold respectively compared to those increasing in SF ARGS (OR 5.72; 95% CI 1.53-21.4 and 3.66; 1.01-13.2, respectively). No significant associations were seen between decreasing SF ARGS and progression of osteophytes (OR 0.88; 0.28-2.78), or for patient-reported outcomes other than KOOS pain. <br/><br>
<br/><br>
CONCLUSION: Having decreasing levels of SF ARGS over time was associated with an increased risk of loss of joint space and pain worsening, but showed no association with other patient-reported outcomes or osteophyte progression.}},
author = {{Larsson, Staffan and Englund, Martin and Struglics, André and Lohmander, Stefan}},
issn = {{1063-4584}},
language = {{eng}},
number = {{5}},
pages = {{388--395}},
publisher = {{Elsevier}},
series = {{Osteoarthritis and Cartilage}},
title = {{The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study.}},
url = {{http://dx.doi.org/10.1016/j.joca.2012.02.001}},
doi = {{10.1016/j.joca.2012.02.001}},
volume = {{20}},
year = {{2012}},
}