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The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study.

Larsson, Staffan LU ; Englund, Martin LU ; Struglics, André LU and Lohmander, Stefan LU (2012) In Osteoarthritis and Cartilage 20(5). p.388-395
Abstract
OBJECTIVE: To investigate whether change in concentrations over time of aggrecanase generated ARGS-aggrecan in synovial fluid (SF ARGS) associates with progression of radiographic knee Osteoarthritis (OA) and patient-reported outcome in subjects with previous meniscectomy.



METHODS: We studied 141 subjects at two time points after meniscectomy. Time point A was on average 18years after meniscectomy, time point B was on average 7.5years later; 74 subjects had SF available from both examinations. We measured SF ARGS by an electrochemiluminescence immunoassay, graded radiographic features of tibiofemoral or patellofemoral OA according to the Osteoarthritis Research Society International (OARSI) atlas, and scored... (More)
OBJECTIVE: To investigate whether change in concentrations over time of aggrecanase generated ARGS-aggrecan in synovial fluid (SF ARGS) associates with progression of radiographic knee Osteoarthritis (OA) and patient-reported outcome in subjects with previous meniscectomy.



METHODS: We studied 141 subjects at two time points after meniscectomy. Time point A was on average 18years after meniscectomy, time point B was on average 7.5years later; 74 subjects had SF available from both examinations. We measured SF ARGS by an electrochemiluminescence immunoassay, graded radiographic features of tibiofemoral or patellofemoral OA according to the Osteoarthritis Research Society International (OARSI) atlas, and scored patient-reported outcomes using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Using logistic regression (adjusted for age, gender, body mass index, time between examinations, and SF ARGS at first examination) we assessed associations between change in SF ARGS between first and second examinations and progression of radiographic OA and KOOS.



RESULTS: In subjects with decreasing SF ARGS between examinations, the likelihood of loss of joint space and worsening of KOOS pain between examinations was increased 6- and 4-fold respectively compared to those increasing in SF ARGS (OR 5.72; 95% CI 1.53-21.4 and 3.66; 1.01-13.2, respectively). No significant associations were seen between decreasing SF ARGS and progression of osteophytes (OR 0.88; 0.28-2.78), or for patient-reported outcomes other than KOOS pain.



CONCLUSION: Having decreasing levels of SF ARGS over time was associated with an increased risk of loss of joint space and pain worsening, but showed no association with other patient-reported outcomes or osteophyte progression. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Osteoarthritis and Cartilage
volume
20
issue
5
pages
388 - 395
publisher
Elsevier
external identifiers
  • wos:000303297100008
  • pmid:22330175
  • scopus:84859423872
ISSN
1063-4584
DOI
10.1016/j.joca.2012.02.001
language
English
LU publication?
yes
id
6da89eda-874e-47e3-9acb-057659a7969a (old id 2366955)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22330175?dopt=Abstract
date added to LUP
2012-03-02 11:29:48
date last changed
2017-11-05 04:39:58
@article{6da89eda-874e-47e3-9acb-057659a7969a,
  abstract     = {OBJECTIVE: To investigate whether change in concentrations over time of aggrecanase generated ARGS-aggrecan in synovial fluid (SF ARGS) associates with progression of radiographic knee Osteoarthritis (OA) and patient-reported outcome in subjects with previous meniscectomy. <br/><br>
<br/><br>
METHODS: We studied 141 subjects at two time points after meniscectomy. Time point A was on average 18years after meniscectomy, time point B was on average 7.5years later; 74 subjects had SF available from both examinations. We measured SF ARGS by an electrochemiluminescence immunoassay, graded radiographic features of tibiofemoral or patellofemoral OA according to the Osteoarthritis Research Society International (OARSI) atlas, and scored patient-reported outcomes using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Using logistic regression (adjusted for age, gender, body mass index, time between examinations, and SF ARGS at first examination) we assessed associations between change in SF ARGS between first and second examinations and progression of radiographic OA and KOOS. <br/><br>
<br/><br>
RESULTS: In subjects with decreasing SF ARGS between examinations, the likelihood of loss of joint space and worsening of KOOS pain between examinations was increased 6- and 4-fold respectively compared to those increasing in SF ARGS (OR 5.72; 95% CI 1.53-21.4 and 3.66; 1.01-13.2, respectively). No significant associations were seen between decreasing SF ARGS and progression of osteophytes (OR 0.88; 0.28-2.78), or for patient-reported outcomes other than KOOS pain. <br/><br>
<br/><br>
CONCLUSION: Having decreasing levels of SF ARGS over time was associated with an increased risk of loss of joint space and pain worsening, but showed no association with other patient-reported outcomes or osteophyte progression.},
  author       = {Larsson, Staffan and Englund, Martin and Struglics, André and Lohmander, Stefan},
  issn         = {1063-4584},
  language     = {eng},
  number       = {5},
  pages        = {388--395},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study.},
  url          = {http://dx.doi.org/10.1016/j.joca.2012.02.001},
  volume       = {20},
  year         = {2012},
}