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High-frequency ultrasound in the evaluation of cerebral intraventricular haemorrhage in preterm rabbit pups.

Sveinsdottir, Snjolaug LU ; Cinthio, Magnus and Ley, David LU (2012) In Ultrasound in Medicine and Biology 38(3). p.423-431
Abstract
Cerebral intraventricular haemorrhage (IVH) is the most common cause of severe neurologic impairment following preterm birth in human infants. Ideally, an animal model for cerebral IVH should allow for reliable noninvasive evaluation of haemorrhagic extension and of subsequent development of posthaemorrhagic ventricular dilatation (PHVD). The aim of this study was to evaluate the use of high-frequency ultrasound (HFU) in premature rabbit pups with cerebral IVH induced by IP glycerol injection. Serial examinations using HFU enabled an accurate description of haemorrhagic extension and measurement of progressive PHVD over 72 h. The coefficient of variation for inter- and intraobserver variability in two measurements of ventricular size was... (More)
Cerebral intraventricular haemorrhage (IVH) is the most common cause of severe neurologic impairment following preterm birth in human infants. Ideally, an animal model for cerebral IVH should allow for reliable noninvasive evaluation of haemorrhagic extension and of subsequent development of posthaemorrhagic ventricular dilatation (PHVD). The aim of this study was to evaluate the use of high-frequency ultrasound (HFU) in premature rabbit pups with cerebral IVH induced by IP glycerol injection. Serial examinations using HFU enabled an accurate description of haemorrhagic extension and measurement of progressive PHVD over 72 h. The coefficient of variation for inter- and intraobserver variability in two measurements of ventricular size was less than 8.8% and 9.3%, respectively. Repeated ultrasound-guided intraventricular injection and sampling could be performed in vivo excluding requirement of stereotactic procedures and sedation. Application of HFU is a powerful tool for the evaluation of mechanisms involved in cerebral IVH and PHVD in the preterm rabbit pup model. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Ultrasound in Medicine and Biology
volume
38
issue
3
pages
423 - 431
publisher
Elsevier
external identifiers
  • wos:000300234800011
  • pmid:22305058
  • scopus:84856563503
ISSN
0301-5629
DOI
10.1016/j.ultrasmedbio.2011.12.003
language
English
LU publication?
yes
id
dcd8a493-b42c-4bf7-97ed-6341f54fee0d (old id 2367295)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22305058?dopt=Abstract
date added to LUP
2012-03-02 08:56:25
date last changed
2017-10-01 05:00:00
@article{dcd8a493-b42c-4bf7-97ed-6341f54fee0d,
  abstract     = {Cerebral intraventricular haemorrhage (IVH) is the most common cause of severe neurologic impairment following preterm birth in human infants. Ideally, an animal model for cerebral IVH should allow for reliable noninvasive evaluation of haemorrhagic extension and of subsequent development of posthaemorrhagic ventricular dilatation (PHVD). The aim of this study was to evaluate the use of high-frequency ultrasound (HFU) in premature rabbit pups with cerebral IVH induced by IP glycerol injection. Serial examinations using HFU enabled an accurate description of haemorrhagic extension and measurement of progressive PHVD over 72 h. The coefficient of variation for inter- and intraobserver variability in two measurements of ventricular size was less than 8.8% and 9.3%, respectively. Repeated ultrasound-guided intraventricular injection and sampling could be performed in vivo excluding requirement of stereotactic procedures and sedation. Application of HFU is a powerful tool for the evaluation of mechanisms involved in cerebral IVH and PHVD in the preterm rabbit pup model.},
  author       = {Sveinsdottir, Snjolaug and Cinthio, Magnus and Ley, David},
  issn         = {0301-5629},
  language     = {eng},
  number       = {3},
  pages        = {423--431},
  publisher    = {Elsevier},
  series       = {Ultrasound in Medicine and Biology},
  title        = {High-frequency ultrasound in the evaluation of cerebral intraventricular haemorrhage in preterm rabbit pups.},
  url          = {http://dx.doi.org/10.1016/j.ultrasmedbio.2011.12.003},
  volume       = {38},
  year         = {2012},
}