2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension : The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT
(2019) In Journal of Heart and Lung Transplantation 38(9). p.879-901- Abstract
The European Pediatric Pulmonary Vascular Disease Network is a registered, non-profit organization that strives to define and develop effective, innovative diagnostic methods and treatment options in all forms of pediatric pulmonary hypertensive vascular disease, including pulmonary hypertension (PH) associated with bronchopulmonary dysplasia, PH associated with congenital heart disease (CHD), persistent PH of the newborn, and related cardiac dysfunction. The executive writing group members conducted searches of the PubMed/MEDLINE bibliographic database (1990–2018) and held face-to-face and web-based meetings. Ten section task forces voted on the updated recommendations, based on the 2016 executive summary. Clinical trials,... (More)
The European Pediatric Pulmonary Vascular Disease Network is a registered, non-profit organization that strives to define and develop effective, innovative diagnostic methods and treatment options in all forms of pediatric pulmonary hypertensive vascular disease, including pulmonary hypertension (PH) associated with bronchopulmonary dysplasia, PH associated with congenital heart disease (CHD), persistent PH of the newborn, and related cardiac dysfunction. The executive writing group members conducted searches of the PubMed/MEDLINE bibliographic database (1990–2018) and held face-to-face and web-based meetings. Ten section task forces voted on the updated recommendations, based on the 2016 executive summary. Clinical trials, meta-analyses, guidelines, and other articles that include pediatric data were searched using the term “pulmonary hypertension” and other keywords. Class of recommendation (COR) and level of evidence (LOE) were assigned based on European Society of Cardiology/American Heart Association definitions and on pediatric data only, or on adult studies that included >10% children or studies that enrolled adults with CHD. New definitions by the World Symposium on Pulmonary Hypertension 2018 were included. We generated 10 tables with graded recommendations (COR/LOE). The topics include diagnosis/monitoring, genetics/biomarkers, cardiac catheterization, echocardiography, cardiac magnetic resonance/chest computed tomography, associated forms of PH, intensive care unit/lung transplantation, and treatment of pediatric PH. For the first time, a set of specific recommendations on the management of PH in middle- and low-income regions was developed. Taken together, these executive, up-to-date guidelines provide a specific, comprehensive, detailed but practical framework for the optimal clinical care of children and young adults with PH.
(Less)
- author
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- children, congenital heart disease, European Pediatric Pulmonary Vascular Disease Network, guidelines, pediatric, pulmonary hypertension, pulmonary vascular disease, right heart failure, right ventricle
- in
- Journal of Heart and Lung Transplantation
- volume
- 38
- issue
- 9
- pages
- 23 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:31495407
- scopus:85071761809
- ISSN
- 1053-2498
- DOI
- 10.1016/j.healun.2019.06.022
- language
- English
- LU publication?
- yes
- id
- 236b94f3-ebdc-4ec9-8af9-8e61825813b6
- date added to LUP
- 2019-09-18 08:08:14
- date last changed
- 2025-05-02 12:04:54
@misc{236b94f3-ebdc-4ec9-8af9-8e61825813b6,
abstract = {{<p>The European Pediatric Pulmonary Vascular Disease Network is a registered, non-profit organization that strives to define and develop effective, innovative diagnostic methods and treatment options in all forms of pediatric pulmonary hypertensive vascular disease, including pulmonary hypertension (PH) associated with bronchopulmonary dysplasia, PH associated with congenital heart disease (CHD), persistent PH of the newborn, and related cardiac dysfunction. The executive writing group members conducted searches of the PubMed/MEDLINE bibliographic database (1990–2018) and held face-to-face and web-based meetings. Ten section task forces voted on the updated recommendations, based on the 2016 executive summary. Clinical trials, meta-analyses, guidelines, and other articles that include pediatric data were searched using the term “pulmonary hypertension” and other keywords. Class of recommendation (COR) and level of evidence (LOE) were assigned based on European Society of Cardiology/American Heart Association definitions and on pediatric data only, or on adult studies that included >10% children or studies that enrolled adults with CHD. New definitions by the World Symposium on Pulmonary Hypertension 2018 were included. We generated 10 tables with graded recommendations (COR/LOE). The topics include diagnosis/monitoring, genetics/biomarkers, cardiac catheterization, echocardiography, cardiac magnetic resonance/chest computed tomography, associated forms of PH, intensive care unit/lung transplantation, and treatment of pediatric PH. For the first time, a set of specific recommendations on the management of PH in middle- and low-income regions was developed. Taken together, these executive, up-to-date guidelines provide a specific, comprehensive, detailed but practical framework for the optimal clinical care of children and young adults with PH.</p>}},
author = {{Hansmann, Georg and Koestenberger, Martin and Alastalo, Tero Pekka and Apitz, Christian and Austin, Eric D. and Bonnet, Damien and Budts, Werner and D'Alto, Michele and Gatzoulis, Michael A. and Hasan, Babar S. and Kozlik-Feldmann, Rainer and Kumar, R. Krishna and Lammers, Astrid E. and Latus, Heiner and Michel-Behnke, Ina and Miera, Oliver and Morrell, Nicholas W. and Pieles, Guido and Quandt, Daniel and Sallmon, Hannes and Schranz, Dietmar and Tran-Lundmark, Karin and Tulloh, Robert M.R. and Warnecke, Gregor and Wåhlander, Håkan and Weber, Sven C. and Zartner, Peter}},
issn = {{1053-2498}},
keywords = {{children; congenital heart disease; European Pediatric Pulmonary Vascular Disease Network; guidelines; pediatric; pulmonary hypertension; pulmonary vascular disease; right heart failure; right ventricle}},
language = {{eng}},
number = {{9}},
pages = {{879--901}},
publisher = {{Elsevier}},
series = {{Journal of Heart and Lung Transplantation}},
title = {{2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension : The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT}},
url = {{http://dx.doi.org/10.1016/j.healun.2019.06.022}},
doi = {{10.1016/j.healun.2019.06.022}},
volume = {{38}},
year = {{2019}},
}