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Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins

Bolton, Derek; Rijsdijk, Fruhling; O'Connor, Thomas; Perrin, Sean LU and Eley, Thalia (2006) In Psychological Medicine 37(1). p.39-48
Abstract
Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found

familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders. Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were

investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results. In the multivariate model combined additive genetic and common environmental effects were... (More)
Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found

familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders. Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were

investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results. In the multivariate model combined additive genetic and common environmental effects were estimated as 47% for sub-threshold OCD, and the model was unable to distinguish these sources of familial aggregation. There were strong familial aggregations between sub-threshold OCD and tics and between sub-threshold OCD and other anxiety disorders (80% and 97% respectively), although again specific sources could not be distinguished. Conclusions. The findings are consistent with the hypothesis of a tic-related early-onset OCD phenotype, but also with the hypothesis of an anxiety-related early-onset OCD phenotype. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychological Medicine
volume
37
issue
1
pages
39 - 48
publisher
Cambridge University Press
external identifiers
  • scopus:33845984942
ISSN
1469-8978
DOI
10.1017/S0033291706008816
language
English
LU publication?
no
id
9c312f50-98d9-4243-a6f3-2af1351699e5 (old id 2373347)
date added to LUP
2012-03-28 11:29:36
date last changed
2017-04-02 04:20:06
@article{9c312f50-98d9-4243-a6f3-2af1351699e5,
  abstract     = {Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found<br/><br>
familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders. Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were<br/><br>
investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results. In the multivariate model combined additive genetic and common environmental effects were estimated as 47% for sub-threshold OCD, and the model was unable to distinguish these sources of familial aggregation. There were strong familial aggregations between sub-threshold OCD and tics and between sub-threshold OCD and other anxiety disorders (80% and 97% respectively), although again specific sources could not be distinguished. Conclusions. The findings are consistent with the hypothesis of a tic-related early-onset OCD phenotype, but also with the hypothesis of an anxiety-related early-onset OCD phenotype.},
  author       = {Bolton, Derek and Rijsdijk, Fruhling and O'Connor, Thomas and Perrin, Sean and Eley, Thalia},
  issn         = {1469-8978},
  language     = {eng},
  number       = {1},
  pages        = {39--48},
  publisher    = {Cambridge University Press},
  series       = {Psychological Medicine},
  title        = {Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins},
  url          = {http://dx.doi.org/10.1017/S0033291706008816},
  volume       = {37},
  year         = {2006},
}