Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins
(2006) In Psychological Medicine 37(1). p.39-48- Abstract
- Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found
familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders. Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were
investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results. In the multivariate model combined additive genetic and common environmental effects were... (More) - Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found
familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders. Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were
investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results. In the multivariate model combined additive genetic and common environmental effects were estimated as 47% for sub-threshold OCD, and the model was unable to distinguish these sources of familial aggregation. There were strong familial aggregations between sub-threshold OCD and tics and between sub-threshold OCD and other anxiety disorders (80% and 97% respectively), although again specific sources could not be distinguished. Conclusions. The findings are consistent with the hypothesis of a tic-related early-onset OCD phenotype, but also with the hypothesis of an anxiety-related early-onset OCD phenotype. (Less)
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https://lup.lub.lu.se/record/2373347
- author
- Bolton, Derek ; Rijsdijk, Fruhling ; O'Connor, Thomas ; Perrin, Sean LU and Eley, Thalia
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Psychological Medicine
- volume
- 37
- issue
- 1
- pages
- 39 - 48
- publisher
- Cambridge University Press
- external identifiers
-
- scopus:33845984942
- pmid:16999878
- ISSN
- 1469-8978
- DOI
- 10.1017/S0033291706008816
- language
- English
- LU publication?
- no
- id
- 9c312f50-98d9-4243-a6f3-2af1351699e5 (old id 2373347)
- date added to LUP
- 2016-04-04 10:07:05
- date last changed
- 2022-03-15 21:12:01
@article{9c312f50-98d9-4243-a6f3-2af1351699e5, abstract = {{Background. Previous reports of genetic influences on obsessive–compulsive disorder (OCD) symptoms have suggested moderate heritability. Family history studies of co-morbidity have found<br/><br> familial aggregation with tics, especially for early-onset OCD, and familial aggregation with anxiety disorders. Method. Heritability of OCD and familial aggregation of OCD, tics and anxiety disorders were<br/><br> investigated in a community sample of 6-year-old twins using a two-phase design in which 4662 twin pairs were sampled and 854 pairs were assessed in the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results. In the multivariate model combined additive genetic and common environmental effects were estimated as 47% for sub-threshold OCD, and the model was unable to distinguish these sources of familial aggregation. There were strong familial aggregations between sub-threshold OCD and tics and between sub-threshold OCD and other anxiety disorders (80% and 97% respectively), although again specific sources could not be distinguished. Conclusions. The findings are consistent with the hypothesis of a tic-related early-onset OCD phenotype, but also with the hypothesis of an anxiety-related early-onset OCD phenotype.}}, author = {{Bolton, Derek and Rijsdijk, Fruhling and O'Connor, Thomas and Perrin, Sean and Eley, Thalia}}, issn = {{1469-8978}}, language = {{eng}}, number = {{1}}, pages = {{39--48}}, publisher = {{Cambridge University Press}}, series = {{Psychological Medicine}}, title = {{Obsessive-compulsive disorder, tics and anxiety in 6-year-old twins}}, url = {{http://dx.doi.org/10.1017/S0033291706008816}}, doi = {{10.1017/S0033291706008816}}, volume = {{37}}, year = {{2006}}, }