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Proteomics-protein profiling technology: the trend towards a microfabricated toolbox concept

Laurell, Thomas LU ; Nilsson, J. and Marko-Varga, György LU (2001) In Trac. Trends in Analytical Chemistry 20(5). p.225-231
Abstract
The use of mono-crystalline silicon microstructures for high-speed and high sensitivity protein mapping and protein identification is presented as an important contribution within the field of proteomics. The various approaches for handling minute amounts of protein sample are described. Piezoelectric dispensing units developed in-house are being used for sample-handling and the generation of 60-pl droplets, interfacing with high-density microchip MALDI-TOF MS target plates having an array density of 4000 nanovials/square inch. Examples of applications to microtechnology, and future trends in our research are outlined. (C) 2001 Elsevier Science B.V. All rights reserved.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
proteomics, microtechnology, mass spectrometry, piezoelectric, dispensing, nanovial, FLIGHT MASS-SPECTROMETRY, SAMPLE PREPARATION, LASER, MICRODISSECTION, CHROMATOGRAPHY, SEPARATIONS, SYSTEMS
in
Trac. Trends in Analytical Chemistry
volume
20
issue
5
pages
225 - 231
publisher
Elsevier
external identifiers
  • wos:000169278500006
  • scopus:0035338540
ISSN
0165-9936
DOI
10.1016/s0165-9936(01)00061-9
language
English
LU publication?
yes
id
200e8f4b-6587-4232-b6fe-f78e45e0d960 (old id 2376380)
date added to LUP
2012-03-23 09:24:28
date last changed
2018-05-29 11:09:49
@article{200e8f4b-6587-4232-b6fe-f78e45e0d960,
  abstract     = {The use of mono-crystalline silicon microstructures for high-speed and high sensitivity protein mapping and protein identification is presented as an important contribution within the field of proteomics. The various approaches for handling minute amounts of protein sample are described. Piezoelectric dispensing units developed in-house are being used for sample-handling and the generation of 60-pl droplets, interfacing with high-density microchip MALDI-TOF MS target plates having an array density of 4000 nanovials/square inch. Examples of applications to microtechnology, and future trends in our research are outlined. (C) 2001 Elsevier Science B.V. All rights reserved.},
  author       = {Laurell, Thomas and Nilsson, J. and Marko-Varga, György},
  issn         = {0165-9936},
  keyword      = {proteomics,microtechnology,mass spectrometry,piezoelectric,dispensing,nanovial,FLIGHT MASS-SPECTROMETRY,SAMPLE PREPARATION,LASER,MICRODISSECTION,CHROMATOGRAPHY,SEPARATIONS,SYSTEMS},
  language     = {eng},
  number       = {5},
  pages        = {225--231},
  publisher    = {Elsevier},
  series       = {Trac. Trends in Analytical Chemistry},
  title        = {Proteomics-protein profiling technology: the trend towards a microfabricated toolbox concept},
  url          = {http://dx.doi.org/10.1016/s0165-9936(01)00061-9},
  volume       = {20},
  year         = {2001},
}