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Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction

Sandrini, Michael LU and Piskur, Jure LU (2005) In Trends in Biochemical Sciences 30(5). p.225-228
Abstract
Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases, which salvage the precursors for nucleic acids synthesis. In addition to the native deoxyribonucleoside substrates, the kinases can phosphorylate and thereby activate a variety of anti-cancer and antiviral prodrugs. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Biochemical Sciences
volume
30
issue
5
pages
225 - 228
publisher
Elsevier
external identifiers
  • wos:000229466300003
  • pmid:15896737
  • scopus:18844367487
ISSN
0167-7640
DOI
10.1016/j.tibs.2005.03.003
language
English
LU publication?
yes
id
1a04644f-f06f-4377-8efc-757054c053d2 (old id 237654)
date added to LUP
2007-08-10 09:08:09
date last changed
2017-05-21 03:38:55
@article{1a04644f-f06f-4377-8efc-757054c053d2,
  abstract     = {Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases, which salvage the precursors for nucleic acids synthesis. In addition to the native deoxyribonucleoside substrates, the kinases can phosphorylate and thereby activate a variety of anti-cancer and antiviral prodrugs. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions.},
  author       = {Sandrini, Michael and Piskur, Jure},
  issn         = {0167-7640},
  language     = {eng},
  number       = {5},
  pages        = {225--228},
  publisher    = {Elsevier},
  series       = {Trends in Biochemical Sciences},
  title        = {Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction},
  url          = {http://dx.doi.org/10.1016/j.tibs.2005.03.003},
  volume       = {30},
  year         = {2005},
}