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The Polyamine Pathway as a Potential Target for Vascular Diseases: Focus on Restenosis

Forte, Amalia; Hellstrand, Per LU ; Nilsson, Bengt-Olof LU ; Grossi, Mario; Rossi, Francesco and Cipollaro, Marilena (2011) In Current Vascular Pharmacology 9(6). p.706-714
Abstract
Polyamines are organic polycations expressed by all living organisms, which are known to play an essential role in cell proliferation and differentiation. Recent studies revealed their involvement also in cell contractility and migration and in programmed cell death. These processes are known to contribute to restenosis, a pathophysiological process occurring in 10-20% of patients submitted to revascularization procedures. The advent of bare metal stents and of drug-eluting stents has significantly reduced but not eliminated the incidence of restenosis, which thus remains a clinically relevant problem. Despite the potential role of the polyamine pathway as a therapeutic target due to its involvement in proliferation, apoptosis and... (More)
Polyamines are organic polycations expressed by all living organisms, which are known to play an essential role in cell proliferation and differentiation. Recent studies revealed their involvement also in cell contractility and migration and in programmed cell death. These processes are known to contribute to restenosis, a pathophysiological process occurring in 10-20% of patients submitted to revascularization procedures. The advent of bare metal stents and of drug-eluting stents has significantly reduced but not eliminated the incidence of restenosis, which thus remains a clinically relevant problem. Despite the potential role of the polyamine pathway as a therapeutic target due to its involvement in proliferation, apoptosis and migration of vascular cells, experimental inhibition of polyamine synthesis and/or uptake has been poorly investigated in animal models of vascular disease. Here we review the current knowledge about molecular mechanisms related to polyamine functions, with particular reference to the role played by polyamines in vascular cell pathophysiology, together with experimental evidence obtained so far in animal models of (re) stenosis. We also evaluate the advantages of different routes of administration of polyamine synthesis/transport inhibitors and polyamine analogue molecules. Increasing knowledge about the molecular mechanisms and functions of polyamines is expected to shed new light on their potential role as a therapeutic target for restenosis reduction. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ornithine decarboxylase, arginase, DFMO, restenosis, neointima, negative, remodelling
in
Current Vascular Pharmacology
volume
9
issue
6
pages
706 - 714
publisher
Bentham Science Publishers
external identifiers
  • wos:000299562400007
  • scopus:80054073475
ISSN
1570-1611
language
English
LU publication?
yes
id
97a7ee70-013f-4b7d-a95d-e7c6646754a1 (old id 2378649)
date added to LUP
2012-04-02 09:20:24
date last changed
2017-01-01 04:18:38
@article{97a7ee70-013f-4b7d-a95d-e7c6646754a1,
  abstract     = {Polyamines are organic polycations expressed by all living organisms, which are known to play an essential role in cell proliferation and differentiation. Recent studies revealed their involvement also in cell contractility and migration and in programmed cell death. These processes are known to contribute to restenosis, a pathophysiological process occurring in 10-20% of patients submitted to revascularization procedures. The advent of bare metal stents and of drug-eluting stents has significantly reduced but not eliminated the incidence of restenosis, which thus remains a clinically relevant problem. Despite the potential role of the polyamine pathway as a therapeutic target due to its involvement in proliferation, apoptosis and migration of vascular cells, experimental inhibition of polyamine synthesis and/or uptake has been poorly investigated in animal models of vascular disease. Here we review the current knowledge about molecular mechanisms related to polyamine functions, with particular reference to the role played by polyamines in vascular cell pathophysiology, together with experimental evidence obtained so far in animal models of (re) stenosis. We also evaluate the advantages of different routes of administration of polyamine synthesis/transport inhibitors and polyamine analogue molecules. Increasing knowledge about the molecular mechanisms and functions of polyamines is expected to shed new light on their potential role as a therapeutic target for restenosis reduction.},
  author       = {Forte, Amalia and Hellstrand, Per and Nilsson, Bengt-Olof and Grossi, Mario and Rossi, Francesco and Cipollaro, Marilena},
  issn         = {1570-1611},
  keyword      = {Ornithine decarboxylase,arginase,DFMO,restenosis,neointima,negative,remodelling},
  language     = {eng},
  number       = {6},
  pages        = {706--714},
  publisher    = {Bentham Science Publishers},
  series       = {Current Vascular Pharmacology},
  title        = {The Polyamine Pathway as a Potential Target for Vascular Diseases: Focus on Restenosis},
  volume       = {9},
  year         = {2011},
}