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The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain

Drake, M. ; Friberg, H. LU ; Boris-Möller, F. LU ; Sakata, K. and Wieloch, T. LU (1996) In Acta Physiologica Scandinavica 158(2). p.155-159
Abstract

The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in a rat model of transient cerebral ischemia induced by occlusion of both common carotid arteries in combination with hypotension for 10 min. Neuronal damage was assessed morphologically after 4 days of recovery. Treatment with FK506, given at a dose of 2 mg kg-1 by intraperitoneal injections 30 min prior to ischemia and once daily during recovery, decreased neuronal damage by 52% in the hippocampal CA1 region and by 48% in the temporal cortex. The protection was not due to diminished body temperature or a marked reduction of ischaemia-induced synaptic overflow of glutamate. We propose that FK506 decreases neuronal damage either by inhibiting... (More)

The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in a rat model of transient cerebral ischemia induced by occlusion of both common carotid arteries in combination with hypotension for 10 min. Neuronal damage was assessed morphologically after 4 days of recovery. Treatment with FK506, given at a dose of 2 mg kg-1 by intraperitoneal injections 30 min prior to ischemia and once daily during recovery, decreased neuronal damage by 52% in the hippocampal CA1 region and by 48% in the temporal cortex. The protection was not due to diminished body temperature or a marked reduction of ischaemia-induced synaptic overflow of glutamate. We propose that FK506 decreases neuronal damage either by inhibiting calcineurin-mediated events or by preserving mitochondrial function.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
FK506, Glutamate, Immunophilin, Ischaemia, Mitochondria, Neuronal death
in
Acta Physiologica Scandinavica
volume
158
issue
2
pages
5 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:8899062
  • scopus:0029846173
ISSN
0001-6772
DOI
10.1046/j.1365-201X.1996.535298000.x
language
English
LU publication?
yes
id
238967d3-7091-4532-be68-23701eb0bcf5
date added to LUP
2019-06-13 15:49:51
date last changed
2020-08-12 08:43:07
@article{238967d3-7091-4532-be68-23701eb0bcf5,
  abstract     = {<p>The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in a rat model of transient cerebral ischemia induced by occlusion of both common carotid arteries in combination with hypotension for 10 min. Neuronal damage was assessed morphologically after 4 days of recovery. Treatment with FK506, given at a dose of 2 mg kg<sup>-1</sup> by intraperitoneal injections 30 min prior to ischemia and once daily during recovery, decreased neuronal damage by 52% in the hippocampal CA1 region and by 48% in the temporal cortex. The protection was not due to diminished body temperature or a marked reduction of ischaemia-induced synaptic overflow of glutamate. We propose that FK506 decreases neuronal damage either by inhibiting calcineurin-mediated events or by preserving mitochondrial function.</p>},
  author       = {Drake, M. and Friberg, H. and Boris-Möller, F. and Sakata, K. and Wieloch, T.},
  issn         = {0001-6772},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {155--159},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Physiologica Scandinavica},
  title        = {The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain},
  url          = {http://dx.doi.org/10.1046/j.1365-201X.1996.535298000.x},
  doi          = {10.1046/j.1365-201X.1996.535298000.x},
  volume       = {158},
  year         = {1996},
}