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Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines

Rydén Ahlgren, Åsa LU ; Cinthio, Magnus LU ; Steen, Stig LU ; Erlöv, Tobias LU ; Sjöberg, Trygve LU ; Persson, Hans W LU and Lindström, Kjell LU (2012) In American Journal of Physiology: Heart and Circulatory Physiology 302(5). p.1102-1115
Abstract
Ahlgren AR, Cinthio M, Steen S, Nilsson T, Sjoberg T, Persson HW, Lindstrom K. Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines. Am J Physiol Heart Circ Physiol 302: H1102-H1115, 2012. First published December 23, 2011; doi:10.1152/ajpheart.00470.2011.-The effects of catecholamines on longitudinal displacements and intramural shear strain of the arterial wall are unexplored. Therefore, the common carotid artery of five anaesthetized pigs was investigated using an in-house developed noninvasive ultrasonic technique. The study protocol included intravenous infusion of low-dose epinephrine (beta-adrenoceptor activation), as well as intravenous boluses of... (More)
Ahlgren AR, Cinthio M, Steen S, Nilsson T, Sjoberg T, Persson HW, Lindstrom K. Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines. Am J Physiol Heart Circ Physiol 302: H1102-H1115, 2012. First published December 23, 2011; doi:10.1152/ajpheart.00470.2011.-The effects of catecholamines on longitudinal displacements and intramural shear strain of the arterial wall are unexplored. Therefore, the common carotid artery of five anaesthetized pigs was investigated using an in-house developed noninvasive ultrasonic technique. The study protocol included intravenous infusion of low-dose epinephrine (beta-adrenoceptor activation), as well as intravenous boluses of norepinephrine (alpha-adrenoceptor activation). Further, the effects of beta-blockade (metoprolol) were studied. There were significant positive correlations between pulse pressure and longitudinal displacement of the intima-media complex (r = 0.72; P < 0.001), as well as between pulse pressure and intramural shear strain (r = 0.48; P < 0.001). Following administration of norepinephrine, the longitudinal displacement of the intima-media complex and intramural shear strain profoundly increased (median 190%, range 102-296%, and median 141%, range 101-182%, respectively, compared with baseline), also when given during beta-blockade (median 228%, range 133-266%, and median 158%, range 152-235%, respectively). During infusion of low-dose epinephrine, the longitudinal displacement of the intima-media complex and intramural shear strain decreased (median 88%, range 69-122%, and median 69%, range 47-117%, respectively, compared with baseline). In conclusion, the present study shows, for the first time, that the longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines. Increase in longitudinal displacements seems to be strongly related to alpha-adrenoceptor activation. Thus metoprolol is insufficient to counteract a profound increase in longitudinal displacement and intramural shear strain following a surge of norepinephrine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
longitudinal movements, epinephrine, norepinephrine, metoprolol, vascular mechanics, ultrasound
in
American Journal of Physiology: Heart and Circulatory Physiology
volume
302
issue
5
pages
1102 - 1115
publisher
American Physiological Society
external identifiers
  • wos:000300720500008
  • scopus:84857278954
ISSN
1522-1539
DOI
10.1152/ajpheart.00470.2011
language
English
LU publication?
yes
id
8d1f1077-bfd3-44f8-b60d-674cda776b6d (old id 2390848)
date added to LUP
2012-03-27 14:27:28
date last changed
2017-08-27 03:34:35
@article{8d1f1077-bfd3-44f8-b60d-674cda776b6d,
  abstract     = {Ahlgren AR, Cinthio M, Steen S, Nilsson T, Sjoberg T, Persson HW, Lindstrom K. Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines. Am J Physiol Heart Circ Physiol 302: H1102-H1115, 2012. First published December 23, 2011; doi:10.1152/ajpheart.00470.2011.-The effects of catecholamines on longitudinal displacements and intramural shear strain of the arterial wall are unexplored. Therefore, the common carotid artery of five anaesthetized pigs was investigated using an in-house developed noninvasive ultrasonic technique. The study protocol included intravenous infusion of low-dose epinephrine (beta-adrenoceptor activation), as well as intravenous boluses of norepinephrine (alpha-adrenoceptor activation). Further, the effects of beta-blockade (metoprolol) were studied. There were significant positive correlations between pulse pressure and longitudinal displacement of the intima-media complex (r = 0.72; P &lt; 0.001), as well as between pulse pressure and intramural shear strain (r = 0.48; P &lt; 0.001). Following administration of norepinephrine, the longitudinal displacement of the intima-media complex and intramural shear strain profoundly increased (median 190%, range 102-296%, and median 141%, range 101-182%, respectively, compared with baseline), also when given during beta-blockade (median 228%, range 133-266%, and median 158%, range 152-235%, respectively). During infusion of low-dose epinephrine, the longitudinal displacement of the intima-media complex and intramural shear strain decreased (median 88%, range 69-122%, and median 69%, range 47-117%, respectively, compared with baseline). In conclusion, the present study shows, for the first time, that the longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines. Increase in longitudinal displacements seems to be strongly related to alpha-adrenoceptor activation. Thus metoprolol is insufficient to counteract a profound increase in longitudinal displacement and intramural shear strain following a surge of norepinephrine.},
  author       = {Rydén Ahlgren, Åsa and Cinthio, Magnus and Steen, Stig and Erlöv, Tobias and Sjöberg, Trygve and Persson, Hans W and Lindström, Kjell},
  issn         = {1522-1539},
  keyword      = {longitudinal movements,epinephrine,norepinephrine,metoprolol,vascular mechanics,ultrasound},
  language     = {eng},
  number       = {5},
  pages        = {1102--1115},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology: Heart and Circulatory Physiology},
  title        = {Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines},
  url          = {http://dx.doi.org/10.1152/ajpheart.00470.2011},
  volume       = {302},
  year         = {2012},
}