Deep-seated ordinary and atypical lipomas - Histopathology, cytogenetics, clinical features, and outcome in 215 tumours of the extremity and trunk wall
(2008) In Journal of Bone and Joint Surgery: British Volume 90B(7). p.929-933- Abstract
- Deep-seated lipomas are often atypical histologically and are considered by some to have a high risk of recurrence after excision. We reviewed 215 deep-seated lipomas of the extremities and trunk wall with reference to histology, cytogenetics, clinical features and local recurrence. We classified tumours with atypical features and/or ring chromosomes as atypical lipomas. These were more common in men, larger than ordinary lipomas and more often located in the upper leg. The annual incidence was estimated as ten per million inhabitants and the ratio of atypical to ordinary lipomas was 1:3. In total, six tumours (3%), recurred locally after a median of eight years (1 to 16); of these, four were classified as atypical. The low recurrence rate... (More)
- Deep-seated lipomas are often atypical histologically and are considered by some to have a high risk of recurrence after excision. We reviewed 215 deep-seated lipomas of the extremities and trunk wall with reference to histology, cytogenetics, clinical features and local recurrence. We classified tumours with atypical features and/or ring chromosomes as atypical lipomas. These were more common in men, larger than ordinary lipomas and more often located in the upper leg. The annual incidence was estimated as ten per million inhabitants and the ratio of atypical to ordinary lipomas was 1:3. In total, six tumours (3%), recurred locally after a median of eight years (1 to 16); of these, four were classified as atypical. The low recurrence rate of deep-seated lipomas of the extremity or trunk wall, irrespective of histological subtype, implies that if surgery is indicated, the tumour may be shelled out, that atypical lipomas in these locations do not deserve the designation well-differentiated liposarcoma, and that routine review after surgery is not required. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1257024
- author
- Billing, V ; Mertens, Fredrik LU ; Domanski, Henryk LU and Rydholm, Anders LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Bone and Joint Surgery: British Volume
- volume
- 90B
- issue
- 7
- pages
- 929 - 933
- publisher
- British Editorial Society of Bone & Joint Surgery
- external identifiers
-
- wos:000257320700020
- scopus:47549091156
- ISSN
- 2044-5377
- DOI
- 10.1302/0301-620X.90B7.20348
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Genetics (013022003), Department of Orthopaedics (Lund) (013028000), Pathology, (Lund) (013030000)
- id
- 23b58132-3ad3-4426-901e-531686902d2b (old id 1257024)
- date added to LUP
- 2016-04-01 11:35:00
- date last changed
- 2022-04-28 17:00:36
@article{23b58132-3ad3-4426-901e-531686902d2b,
abstract = {{Deep-seated lipomas are often atypical histologically and are considered by some to have a high risk of recurrence after excision. We reviewed 215 deep-seated lipomas of the extremities and trunk wall with reference to histology, cytogenetics, clinical features and local recurrence. We classified tumours with atypical features and/or ring chromosomes as atypical lipomas. These were more common in men, larger than ordinary lipomas and more often located in the upper leg. The annual incidence was estimated as ten per million inhabitants and the ratio of atypical to ordinary lipomas was 1:3. In total, six tumours (3%), recurred locally after a median of eight years (1 to 16); of these, four were classified as atypical. The low recurrence rate of deep-seated lipomas of the extremity or trunk wall, irrespective of histological subtype, implies that if surgery is indicated, the tumour may be shelled out, that atypical lipomas in these locations do not deserve the designation well-differentiated liposarcoma, and that routine review after surgery is not required.}},
author = {{Billing, V and Mertens, Fredrik and Domanski, Henryk and Rydholm, Anders}},
issn = {{2044-5377}},
language = {{eng}},
number = {{7}},
pages = {{929--933}},
publisher = {{British Editorial Society of Bone & Joint Surgery}},
series = {{Journal of Bone and Joint Surgery: British Volume}},
title = {{Deep-seated ordinary and atypical lipomas - Histopathology, cytogenetics, clinical features, and outcome in 215 tumours of the extremity and trunk wall}},
url = {{http://dx.doi.org/10.1302/0301-620X.90B7.20348}},
doi = {{10.1302/0301-620X.90B7.20348}},
volume = {{90B}},
year = {{2008}},
}