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Pulmonary Embolism Associated With Protein C Deficiency and Abuse of Anabolic-androgen Steroids

Alhadad, Alaa LU ; Acosta, Stefan LU orcid ; Sarabi, Latif and Kölbel, Tilo LU (2010) In Clinical and Applied Thrombosis/Hemostasis 16(2). p.228-231
Abstract
We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Applied Thrombosis/Hemostasis
volume
16
issue
2
pages
228 - 231
publisher
SAGE Publications
external identifiers
  • wos:000275738500019
  • scopus:77949876536
  • pmid:18977778
ISSN
1938-2723
DOI
10.1177/1076029608324930
language
English
LU publication?
yes
id
23f18d70-d799-4c82-b1fe-4ee419966642 (old id 1588099)
date added to LUP
2016-04-01 11:14:06
date last changed
2022-01-26 06:24:22
@article{23f18d70-d799-4c82-b1fe-4ee419966642,
  abstract     = {{We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.}},
  author       = {{Alhadad, Alaa and Acosta, Stefan and Sarabi, Latif and Kölbel, Tilo}},
  issn         = {{1938-2723}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{228--231}},
  publisher    = {{SAGE Publications}},
  series       = {{Clinical and Applied Thrombosis/Hemostasis}},
  title        = {{Pulmonary Embolism Associated With Protein C Deficiency and Abuse of Anabolic-androgen Steroids}},
  url          = {{http://dx.doi.org/10.1177/1076029608324930}},
  doi          = {{10.1177/1076029608324930}},
  volume       = {{16}},
  year         = {{2010}},
}