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Increased survival of embryonic nigral neurons when grafted to hypothermic rats

Karlsson, Jenny LU ; Emgård, Mia LU ; Gidö, Gunilla LU ; Wieloch, Tadeusz LU and Brundin, Patrik LU (2000) In NeuroReport 11(8). p.1665-1668
Abstract

Hypothermia can reduce neuronal death caused by ischemia and traumatic brain injury. We therefore investigated whether mild hypothermia in rats receiving a transplant of embryonic mesencephalic rat tissue increases survival of the implanted dopaminergic neurons. Mild hypothermia (32-33°C) during graft implantation and for the following 90 min significantly increased the survival of transplanted dopaminergic neurons to 171% of control values in normothermic (37°C) rats. This demonstrates that treatment of the graft recipient for a relatively short period during and after surgery has a favorable effect on the survival of grafted dopaminergic neurons. These findings may be of importance for clinical neural transplantation trials which are... (More)

Hypothermia can reduce neuronal death caused by ischemia and traumatic brain injury. We therefore investigated whether mild hypothermia in rats receiving a transplant of embryonic mesencephalic rat tissue increases survival of the implanted dopaminergic neurons. Mild hypothermia (32-33°C) during graft implantation and for the following 90 min significantly increased the survival of transplanted dopaminergic neurons to 171% of control values in normothermic (37°C) rats. This demonstrates that treatment of the graft recipient for a relatively short period during and after surgery has a favorable effect on the survival of grafted dopaminergic neurons. These findings may be of importance for clinical neural transplantation trials which are in need of procedures that improve transplant survival. (C) 2000 Lippincott Williams and Wilkins.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dopamine, Hypothermia, Mesencephalic, Neural transplantation, Parkinson's disease
in
NeuroReport
volume
11
issue
8
pages
4 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0034608665
ISSN
0959-4965
language
English
LU publication?
yes
id
23fcc6a5-3cc1-4843-bb02-f8c43c708b7e
date added to LUP
2016-10-05 19:00:54
date last changed
2017-07-23 05:18:41
@article{23fcc6a5-3cc1-4843-bb02-f8c43c708b7e,
  abstract     = {<p>Hypothermia can reduce neuronal death caused by ischemia and traumatic brain injury. We therefore investigated whether mild hypothermia in rats receiving a transplant of embryonic mesencephalic rat tissue increases survival of the implanted dopaminergic neurons. Mild hypothermia (32-33°C) during graft implantation and for the following 90 min significantly increased the survival of transplanted dopaminergic neurons to 171% of control values in normothermic (37°C) rats. This demonstrates that treatment of the graft recipient for a relatively short period during and after surgery has a favorable effect on the survival of grafted dopaminergic neurons. These findings may be of importance for clinical neural transplantation trials which are in need of procedures that improve transplant survival. (C) 2000 Lippincott Williams and Wilkins.</p>},
  author       = {Karlsson, Jenny and Emgård, Mia and Gidö, Gunilla and Wieloch, Tadeusz and Brundin, Patrik},
  issn         = {0959-4965},
  keyword      = {Dopamine, Hypothermia,Mesencephalic,Neural transplantation,Parkinson's disease},
  language     = {eng},
  month        = {06},
  number       = {8},
  pages        = {1665--1668},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Increased survival of embryonic nigral neurons when grafted to hypothermic rats},
  volume       = {11},
  year         = {2000},
}