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Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden

Johansson, H.; Oden, A.; Kanis, J.; McCloskey, E.; Lorentzon, M.; Ljunggren, O.; Karlsson, Magnus LU ; Thorsby, P. M.; Tivesten, A. and Barrett-Connor, E., et al. (2012) In Osteoporosis International 23(3). p.991-999
Abstract
In elderly man, low serum 25-hydroxyvitamin D (25(OH)D) was associated with a substantial excess risk of death compared to 25(OH)D values greater than 50-70 nmol/l, but the association attenuated with time. The aim of the present study was to determine whether poor vitamin D status was associated with an increase in the risk of death in elderly men. We studied the relationship between serum 25(OH)D and the risk of death in 2,878 elderly men drawn from the population and recruited to the MrOS study in Sweden. Baseline data included general health and lifestyle measures and serum 25(OH)D measured by competitive RIA. Men were followed for up to 8.2 years (average 6.0 years). Mortality adjusted for comorbidities decreased by 5% for each SD... (More)
In elderly man, low serum 25-hydroxyvitamin D (25(OH)D) was associated with a substantial excess risk of death compared to 25(OH)D values greater than 50-70 nmol/l, but the association attenuated with time. The aim of the present study was to determine whether poor vitamin D status was associated with an increase in the risk of death in elderly men. We studied the relationship between serum 25(OH)D and the risk of death in 2,878 elderly men drawn from the population and recruited to the MrOS study in Sweden. Baseline data included general health and lifestyle measures and serum 25(OH)D measured by competitive RIA. Men were followed for up to 8.2 years (average 6.0 years). Mortality adjusted for comorbidities decreased by 5% for each SD increase in 25(OH)D overall (gradient of risk 1.05; 95% confidence interval 0.96-1.14). The predictive value of 25(OH)D for death was greatest below a threshold value of 50-70 nmol/l, was greatest at approximately 3 years after baseline and thereafter decreased with time. Low serum 25(OH)D is associated with a substantial excess risk of death compared to 25(OH)D values greater than 50-70 nmol/l, but the association attenuates with time. These findings, if causally related, have important implications for intervention in elderly men. (Less)
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published
subject
keywords
Comorbidity, Interaction with time, Mortality, Population studies, Serum, vitamin D, Spline Poisson, regression model
in
Osteoporosis International
volume
23
issue
3
pages
991 - 999
publisher
Springer
external identifiers
  • wos:000300251200022
  • scopus:84857441778
ISSN
1433-2965
DOI
10.1007/s00198-011-1809-5
language
English
LU publication?
yes
id
85a814a2-dd9f-499e-8113-451fc112f94a (old id 2403402)
date added to LUP
2012-04-02 09:29:43
date last changed
2017-09-10 04:22:44
@article{85a814a2-dd9f-499e-8113-451fc112f94a,
  abstract     = {In elderly man, low serum 25-hydroxyvitamin D (25(OH)D) was associated with a substantial excess risk of death compared to 25(OH)D values greater than 50-70 nmol/l, but the association attenuated with time. The aim of the present study was to determine whether poor vitamin D status was associated with an increase in the risk of death in elderly men. We studied the relationship between serum 25(OH)D and the risk of death in 2,878 elderly men drawn from the population and recruited to the MrOS study in Sweden. Baseline data included general health and lifestyle measures and serum 25(OH)D measured by competitive RIA. Men were followed for up to 8.2 years (average 6.0 years). Mortality adjusted for comorbidities decreased by 5% for each SD increase in 25(OH)D overall (gradient of risk 1.05; 95% confidence interval 0.96-1.14). The predictive value of 25(OH)D for death was greatest below a threshold value of 50-70 nmol/l, was greatest at approximately 3 years after baseline and thereafter decreased with time. Low serum 25(OH)D is associated with a substantial excess risk of death compared to 25(OH)D values greater than 50-70 nmol/l, but the association attenuates with time. These findings, if causally related, have important implications for intervention in elderly men.},
  author       = {Johansson, H. and Oden, A. and Kanis, J. and McCloskey, E. and Lorentzon, M. and Ljunggren, O. and Karlsson, Magnus and Thorsby, P. M. and Tivesten, A. and Barrett-Connor, E. and Ohlsson, C. and Mellstrom, D.},
  issn         = {1433-2965},
  keyword      = {Comorbidity,Interaction with time,Mortality,Population studies,Serum,vitamin D,Spline Poisson,regression model},
  language     = {eng},
  number       = {3},
  pages        = {991--999},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden},
  url          = {http://dx.doi.org/10.1007/s00198-011-1809-5},
  volume       = {23},
  year         = {2012},
}