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The impact of nicotine on bone healing and osseointegration - An experimental study in rabbits

Balatsouka, D; Gotfredsen, K; Lindh, Christian LU and Berglundh, T (2005) In Clinical Oral Implants Research 16(3). p.268-276
Abstract
Objecives: To examine the short-term effect of nicotine on bone healing and osseointegration. Material and methods: Sixteen female rabbits were divided into two groups. The test group was exposed to nicotine tartrate for 8 weeks and the control group was exposed to placebo. Nicotine or placebo was administered via a miniosmotic pump and plasma cotinine levels were measured weekly. The pump delivered 15 mg of nicotine/day for the animals in the test group. All rabbits had three tibial bone preparations. In the proximal and distal bone bed, implants were placed after 4 weeks (right tibia) and after 6 weeks (left tibia). Thus, 2- and 4-week healing groups were created. Removal torque test (RMT) was performed at the distal implants. Ground... (More)
Objecives: To examine the short-term effect of nicotine on bone healing and osseointegration. Material and methods: Sixteen female rabbits were divided into two groups. The test group was exposed to nicotine tartrate for 8 weeks and the control group was exposed to placebo. Nicotine or placebo was administered via a miniosmotic pump and plasma cotinine levels were measured weekly. The pump delivered 15 mg of nicotine/day for the animals in the test group. All rabbits had three tibial bone preparations. In the proximal and distal bone bed, implants were placed after 4 weeks (right tibia) and after 6 weeks (left tibia). Thus, 2- and 4-week healing groups were created. Removal torque test (RMT) was performed at the distal implants. Ground sections were made from the proximal and the central bone beds. The fraction of mineralized bone in contact to the implant (BIC) and the bone density within the implant threads (BD-i) were determined for the bone-implant specimens. For the central bone beds without implants the bone density (BD-c) in the bone defects was determined. Results: No significant difference in RMT values was found between the test and the control group. Histomorphometric measurements of the BIC and the peri-implant BD-i showed no significant differences between the test and the control group after 2 or 4 weeks. Significant differences were, however, found between the 2- and 4-week samples. In the central bone beds, there was no significant difference in BD-c between the test and the control group. Conclusion: Nicotine exposure in a short period of time did not have a significant impact on bone healing or implant osseointegration in rabbits. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
rabbits, osseointegration, nicotine, bone healing, histomorphometry, stereology, removal torque test
in
Clinical Oral Implants Research
volume
16
issue
3
pages
268 - 276
publisher
Wiley-Blackwell
external identifiers
  • pmid:15877746
  • wos:000228964900002
  • scopus:25144470769
ISSN
1600-0501
DOI
10.1111/j.1600-0501.2005.01122.x
language
English
LU publication?
yes
id
c87eb656-3720-4dd6-8f85-a36aeb7cdb6a (old id 240582)
date added to LUP
2007-09-17 19:18:16
date last changed
2017-10-22 04:50:41
@article{c87eb656-3720-4dd6-8f85-a36aeb7cdb6a,
  abstract     = {Objecives: To examine the short-term effect of nicotine on bone healing and osseointegration. Material and methods: Sixteen female rabbits were divided into two groups. The test group was exposed to nicotine tartrate for 8 weeks and the control group was exposed to placebo. Nicotine or placebo was administered via a miniosmotic pump and plasma cotinine levels were measured weekly. The pump delivered 15 mg of nicotine/day for the animals in the test group. All rabbits had three tibial bone preparations. In the proximal and distal bone bed, implants were placed after 4 weeks (right tibia) and after 6 weeks (left tibia). Thus, 2- and 4-week healing groups were created. Removal torque test (RMT) was performed at the distal implants. Ground sections were made from the proximal and the central bone beds. The fraction of mineralized bone in contact to the implant (BIC) and the bone density within the implant threads (BD-i) were determined for the bone-implant specimens. For the central bone beds without implants the bone density (BD-c) in the bone defects was determined. Results: No significant difference in RMT values was found between the test and the control group. Histomorphometric measurements of the BIC and the peri-implant BD-i showed no significant differences between the test and the control group after 2 or 4 weeks. Significant differences were, however, found between the 2- and 4-week samples. In the central bone beds, there was no significant difference in BD-c between the test and the control group. Conclusion: Nicotine exposure in a short period of time did not have a significant impact on bone healing or implant osseointegration in rabbits.},
  author       = {Balatsouka, D and Gotfredsen, K and Lindh, Christian and Berglundh, T},
  issn         = {1600-0501},
  keyword      = {rabbits,osseointegration,nicotine,bone healing,histomorphometry,stereology,removal torque test},
  language     = {eng},
  number       = {3},
  pages        = {268--276},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Oral Implants Research},
  title        = {The impact of nicotine on bone healing and osseointegration - An experimental study in rabbits},
  url          = {http://dx.doi.org/10.1111/j.1600-0501.2005.01122.x},
  volume       = {16},
  year         = {2005},
}